Occult and previous hepatitis B virus infection are not associated with hepatocellular carcinoma in United States patients with chronic hepatitis C
dc.contributor.author | Lok, Anna Suk-Fong | en_US |
dc.contributor.author | Everhart, James E. | en_US |
dc.contributor.author | Di Bisceglie, Adrian M. | en_US |
dc.contributor.author | Kim, Hae‐Young | en_US |
dc.contributor.author | Hussain, Munira T. | en_US |
dc.contributor.author | Morgan, Timothy R. | en_US |
dc.date.accessioned | 2011-11-10T15:34:42Z | |
dc.date.available | 2012-10-01T18:34:29Z | en_US |
dc.date.issued | 2011-08 | en_US |
dc.identifier.citation | Lok, Anna S.; Everhart, James E.; Di Bisceglie, Adrian M.; Kim, Hae‐young ; Hussain, Munira; Morgan, Timothy R. (2011). "Occult and previous hepatitis B virus infection are not associated with hepatocellular carcinoma in United States patients with chronic hepatitis C ." Hepatology 54(2): 434-442. <http://hdl.handle.net/2027.42/86955> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/86955 | |
dc.description.abstract | Previous studies have suggested that prior exposure to hepatitis B virus (HBV) infection may increase the risk of development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C. The aim of this study was to compare the prevalence of previous or occult HBV infection in a cohort of hepatitis B surface antigen–negative patients with histologically advanced chronic hepatitis C in the United States who did or did not develop HCC. Stored sera from 91 patients with HCC and 182 matched controls who participated in the Hepatitis C Antiviral Long‐term Treatment against Cirrhosis (HALT‐C) Trial were tested for hepatitis B core antibody (anti‐HBc), hepatitis B surface antibody, and HBV DNA. Frozen liver samples from 28 HCC cases and 55 controls were tested for HBV DNA by way of real‐time polymerase chain reaction. Anti‐HBc (as a marker of previous HBV infection) was present in the serum of 41.8% HCC cases and 45.6% controls ( P = 0.54); anti‐HBc alone was present in 16.5% of HCC cases and 24.7% of controls. HBV DNA was detected in the serum of only one control subject and no patients with HCC. HBV DNA (as a marker of occult HBV infection) was detected in the livers of 10.7% of HCC cases and 23.6% of controls ( P = 0.18). Conclusion: Although almost half the patients in the HALT‐C Trial had serological evidence of previous HBV infection, there was no difference in prevalence of anti‐HBc in serum or HBV DNA in liver between patients who did or did not develop HCC. In the United States, neither previous nor occult HBV infection is an important factor in HCC development among patients with advanced chronic hepatitis C. (H epatology 2011;) | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.title | Occult and previous hepatitis B virus infection are not associated with hepatocellular carcinoma in United States patients with chronic hepatitis C | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, 1500 E Medical Center Drive, 3912 Taubman Center, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationother | Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD | en_US |
dc.contributor.affiliationother | Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, MO | en_US |
dc.contributor.affiliationother | New England Research Institutes, Watertown, MA | en_US |
dc.contributor.affiliationother | Division of Gastroenterology, University of California, Irvine, Irvine, CA | en_US |
dc.contributor.affiliationother | Gastroenterology Service, VA Long Beach Healthcare System, Long Beach, CA | en_US |
dc.identifier.pmid | 21374690 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/86955/1/24257_ftp.pdf | |
dc.identifier.doi | 10.1002/hep.24257 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.identifier.citedreference | Raimondo G, Allain JP, Brunetto MR, Buendia MA, Chen DS, Colombo M, et al. Statements from the Taormina expert meeting on occult hepatitis B virus infection. J Hepatol 2008; 49: 652 ‐ 657. | en_US |
dc.identifier.citedreference | Torbenson M, Thomas DL. Occult hepatitis B. Lancet Infect Dis 2002; 2: 479 ‐ 486. | en_US |
dc.identifier.citedreference | Brechot C, Thiers V, Kremsdorf D, Nalpas B, Pol S, Paterlini‐Brechot P. Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely “occult”? [see comments]. Hepatology 2001; 34: 194 ‐ 203. | en_US |
dc.identifier.citedreference | Pollicino T, Squadrito G, Cerenzia G, Cacciola I, Raffa G, Craxi A, et al. Hepatitis B virus maintains its pro‐oncogenic properties in the case of occult HBV infection. Gastroenterology 2004; 126: 102 ‐ 110. | en_US |
dc.identifier.citedreference | Di Bisceglie AM, Shiffman ML, Everson GT, Lindsay KL, Everhart JE, Wright EC, et al. Prolonged therapy of advanced chronic hepatitis C with low‐dose peginterferon. N Engl J Med 2008; 359: 2429 ‐ 2441. | en_US |
dc.identifier.citedreference | Lee WM, Dienstag JL, Lindsay KL, Lok AS, Bonkovsky HL, Shiffman ML, et al. Evolution of the HALT‐C Trial: pegylated interferon as maintenance therapy for chronic hepatitis C in previous interferon nonresponders. Control Clin Trials 2004; 25: 472 ‐ 492. | en_US |
dc.identifier.citedreference | Lok AS, Seeff LB, Morgan TR, di Bisceglie AM, Sterling RK, Curto TM, et al. Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C‐related advanced liver disease. Gastroenterology 2009; 136: 138 ‐ 148. | en_US |
dc.identifier.citedreference | Hussain M, Soldevila‐Pico C, Emre S, Luketic V, Lok AS. Presence of intrahepatic (total and ccc) HBV DNA is not predictive of HBV recurrence after liver transplantation. Liver Transpl 2007; 13: 1137 ‐ 1144. | en_US |
dc.identifier.citedreference | Obika M, Shinji T, Fujioka S, Terada R, Ryuko H, Lwin AA, et al. Hepatitis B virus DNA in liver tissue and risk for hepatocarcinogenesis in patients with hepatitis C virus‐related chronic liver disease. A prospective study. Intervirology 2008; 51: 59 ‐ 68. | en_US |
dc.identifier.citedreference | Koike K, Shimotouno K, Okada S, Okamoto H, Hayashi N, Ueda K, et al. Survey of hepatitis B virus co‐infection in hepatitis C virus‐infected patients suffering from chronic hepatitis and hepatocellular carcinoma in Japan. Jpn J Cancer Res 1999; 90: 1270 ‐ 1272. | en_US |
dc.identifier.citedreference | Momosaki S, Nakashima Y, Kojiro M, Tabor E. HBsAg‐negative hepatitis B virus infections in hepatitis C virus‐associated hepatocellular carcinoma. J Viral Hepat 2005; 12: 325 ‐ 329. | en_US |
dc.identifier.citedreference | Matsuoka S, Nirei K, Tamura A, Nakamura H, Matsumura H, Oshiro S, et al. Influence of occult hepatitis B virus coinfection on the incidence of fibrosis and hepatocellular carcinoma in chronic hepatitis C. Intervirology 2008; 51: 352 ‐ 361. | en_US |
dc.identifier.citedreference | Squadrito G, Pollicino T, Cacciola I, Caccamo G, Villari D, La Masa T, et al. Occult hepatitis B virus infection is associated with the development of hepatocellular carcinoma in chronic hepatitis C patients. Cancer 2006; 106: 1326 ‐ 1330. | en_US |
dc.identifier.citedreference | Miura Y, Shibuya A, Adachi S, Takeuchi A, Tsuchihashi T, Nakazawa T, et al. Occult hepatitis B virus infection as a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C in whom viral eradication fails. Hepatol Res 2008; 38: 546 ‐ 556. | en_US |
dc.identifier.citedreference | Shintani Y, Yotsuyanagi H, Moriya K, Fujie H, Tsutsumi T, Takayama T, et al. The significance of hepatitis B virus DNA detected in hepatocellular carcinoma of patients with hepatitis C. Cancer 2000; 88: 2478 ‐ 2486. | en_US |
dc.identifier.citedreference | Kao JH, Chen PJ, Lai MY, Chen DS. Occult hepatitis B virus infection and clinical outcomes of patients with chronic hepatitis C. J Clin Microbiol 2002; 40: 4068 ‐ 4071. | en_US |
dc.identifier.citedreference | Adachi S, Shibuya A, Miura Y, Takeuchi A, Nakazawa T, Saigenji K. Impact of occult hepatitis B virus infection and prior hepatitis B virus infection on development of hepatocellular carcinoma in patients with liver cirrhosis due to hepatitis C virus. Scand J Gastroenterol 2008; 43: 849 ‐ 856. | en_US |
dc.identifier.citedreference | Cacciola I, Pollicino T, Squadrito G, Cerenzia G, Orlando ME, Raimondo G. Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. N Engl J Med 1999; 341: 22 ‐ 26. | en_US |
dc.identifier.citedreference | Toyoda H, Kumada T, Kiriyama S, Sone Y, Tanikawa M, Hisanaga Y, et al. Prevalence of low‐level hepatitis B viremia in patients with HBV surface antigen‐negative hepatocellular carcinoma with and without hepatitis C virus infection in Japan: analysis by COBAS TaqMan real‐time PCR. Intervirology 2007; 50: 241 ‐ 244. | en_US |
dc.identifier.citedreference | Yuen MF, Wong DK, Fung J, Ip P, But D, Hung I, et al. HBsAg seroclearance in chronic hepatitis B in Asian patients: replicative level and risk of hepatocellular carcinoma. Gastroenterology 2008; 135: 1192 ‐ 1199. | en_US |
dc.identifier.citedreference | Rehermann B, Ferrari C, Pasquinelli C, Chisari FV. The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T‐lymphocyte response. Nat Med 1996; 2: 1104 ‐ 1108. | en_US |
dc.identifier.citedreference | Michalak TI, Pardoe IU, Coffin CS, Churchill ND, Freake DS, Smith P, et al. Occult lifelong persistence of infectious hepadnavirus and residual liver inflammation in woodchucks convalescent from acute viral hepatitis. Hepatology 1999; 29: 928 ‐ 938. | en_US |
dc.identifier.citedreference | Yamamoto K, Horikita M, Tsuda F, Itoh K, Akahane Y, Yotsumoto S, et al. Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J Virol 1994; 68: 2671 ‐ 2676. | en_US |
dc.identifier.citedreference | Shih CM, Lo SJ, Miyamura T, Chen SY, Lee YH. Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH‐7 cells. J Virol 1993; 67: 5823 ‐ 5832. | en_US |
dc.identifier.citedreference | Michalak TI, Mulrooney PM, Coffin CS. Low doses of hepadnavirus induce infection of the lymphatic system that does not engage the liver. J Virol 2004; 78: 1730 ‐ 1738. | en_US |
dc.identifier.citedreference | Zerbini A, Pilli M, Boni C, Fisicaro P, Penna A, Di Vincenzo P, et al. The characteristics of the cell‐mediated immune response identify different profiles of occult hepatitis B virus infection. Gastroenterology 2008; 134: 1470 ‐ 1481. | en_US |
dc.identifier.citedreference | Ikeda K, Marusawa H, Osaki Y, Nakamura T, Kitajima N, Yamashita Y, et al. Antibody to hepatitis B core antigen and risk for hepatitis C‐related hepatocellular carcinoma: a prospective study. Ann Intern Med 2007; 146: 649 ‐ 656. | en_US |
dc.identifier.citedreference | Hsia CC, Scudamore CH, Di Bisceglie AM, Tabor E. Molecular and serological aspects of HBsAg‐negative hepatitis B virus infections in North America. J Med Virol 2003; 70: 20 ‐ 26. | en_US |
dc.identifier.citedreference | Kannangai R, Molmenti E, Arrazola L, Klein A, Choti M, Thomas DL, et al. Occult hepatitis B viral DNA in liver carcinomas from a region with a low prevalence of chronic hepatitis B infection. J Viral Hepat 2004; 11: 297 ‐ 301. | en_US |
dc.identifier.citedreference | Shetty K, Hussain M, Nei L, Reddy KR, Lok AS. Prevalence and significance of occult hepatitis B in a liver transplant population with chronic hepatitis C. Liver Transpl 2008; 14: 534 ‐ 540. Erratum in: Liver Transpl 2011;17:97. | en_US |
dc.identifier.citedreference | Shetty K, Hussain M, Nei L, Reddy KR, Lok AS. Erratum: Prevalence and significance of occult hepatitis B in a liver transplant population with chronic hepatitis C. Liver Transpl 2011; 17: 97. | en_US |
dc.identifier.citedreference | Chen YC, Sheen IS, Chu CM, Liaw YF. Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection. Gastroenterology 2002; 123: 1084 ‐ 1089. | en_US |
dc.identifier.citedreference | Pollicino T, Raffa G, Costantino L, Lisa A, Campello C, Squadrito G, et al. Molecular and functional analysis of occult hepatitis B virus isolates from patients with hepatocellular carcinoma. Hepatology 2007; 45: 277 ‐ 285. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.