Microdialysis and mass spectrometric monitoring of dopamine and enkephalins in the globus pallidus reveal reciprocal interactions that regulate movement
dc.contributor.author | Mabrouk, Omar S. | en_US |
dc.contributor.author | Li, Qiang | en_US |
dc.contributor.author | Song, Peng | en_US |
dc.contributor.author | Kennedy, Robert T. | en_US |
dc.date.accessioned | 2011-11-10T15:35:16Z | |
dc.date.available | 2012-09-04T15:27:43Z | en_US |
dc.date.issued | 2011-07 | en_US |
dc.identifier.citation | Mabrouk, Omar S.; Li, Qiang; Song, Peng; Kennedy, Robert T. (2011). "Microdialysis and mass spectrometric monitoring of dopamine and enkephalins in the globus pallidus reveal reciprocal interactions that regulate movement." Journal of Neurochemistry 118(1). <http://hdl.handle.net/2027.42/86977> | en_US |
dc.identifier.issn | 0022-3042 | en_US |
dc.identifier.issn | 1471-4159 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/86977 | |
dc.description.abstract | Pallidal dopamine, GABA and the endogenous opioid peptides enkephalins have independently been shown to be important controllers of sensorimotor processes. Using in vivo microdialysis coupled to liquid chromatography–mass spectrometry and a behavioral assay, we explored the interaction between these three neurotransmitters in the rat globus pallidus. Amphetamine (3 mg/kg i.p.) evoked an increase in dopamine, GABA and methionine/leucine enkephalin. Local perfusion of the dopamine D 1 receptor antagonist SCH 23390 (100 μM) fully prevented amphetamine stimulated enkephalin and GABA release in the globus pallidus and greatly suppressed hyperlocomotion. In contrast, the dopamine D 2 receptor antagonist raclopride (100 μM) had only minimal effects suggesting a greater role for pallidal D 1 over D 2 receptors in the regulation of movement. Under basal conditions, opioid receptor blockade by naloxone perfusion (10 μM) in the globus pallidus stimulated GABA and inhibited dopamine release. Amphetamine‐stimulated dopamine release and locomotor activation were attenuated by naloxone perfusion with no effect on GABA. These findings demonstrate a functional relationship between pallidal dopamine, GABA and enkephalin systems in the control of locomotor behavior under basal and stimulated conditions. Moreover, these findings demonstrate the usefulness of liquid chromatography–mass spectrometry as an analytical tool when coupled to in vivo microdialysis. | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Amphetamine | en_US |
dc.subject.other | Dopamine | en_US |
dc.subject.other | Enkephalins | en_US |
dc.subject.other | Globus Pallidus | en_US |
dc.subject.other | Mass Spectrometry | en_US |
dc.subject.other | Microdialysis | en_US |
dc.title | Microdialysis and mass spectrometric monitoring of dopamine and enkephalins in the globus pallidus reveal reciprocal interactions that regulate movement | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/86977/1/j.1471-4159.2011.07293.x.pdf | |
dc.identifier.doi | 10.1111/j.1471-4159.2011.07293.x | en_US |
dc.identifier.source | Journal of Neurochemistry | en_US |
dc.identifier.citedreference | Alesdatter J. E. and Kalivas P. W. ( 1993 ) Inhibition of mu opioid‐induced motor activity in the ventral pallidum by D 1 receptor blockade. Behav. Pharmacol. 4, 645 – 651. | en_US |
dc.identifier.citedreference | Alexander G. E., DeLong M. R. and Strick P. L. ( 1986 ) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 9, 357 – 381. | en_US |
dc.identifier.citedreference | Anagnostakis Y., Krikos Y. and Spyraki C. ( 1992 ) Pallidal substrate of morphine‐induced locomotion. Eur. Neuropsychopharmacol. 2, 65 – 72. | en_US |
dc.identifier.citedreference | Avdelidis D. and Spyraki C. ( 1986 ) Dopamine dependent behaviours in rats with bilateral ibotenic acid‐induced lesions of the globus pallidus. Brain Res. Bull. 16, 25 – 32. | en_US |
dc.identifier.citedreference | Baamonde A., Daugé V., Ruiz‐Gayo M., Fulga I. G., Turcaud S., Fournié‐Zaluski M. C. and Roques B. P. ( 1992 ) Antidepressant‐type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D 1 receptor stimulation. Eur. J. Pharmacol. 216, 157 – 166. | en_US |
dc.identifier.citedreference | Barone P., Tucci I., Parashos S. A. and Chase T. N. ( 1987 ) D‐1 dopamine receptor changes after striatal quinolinic acid lesion. Eur. J. Pharmacol. 138, 141 – 145. | en_US |
dc.identifier.citedreference | Bartlett L. E. and Mendez I. ( 2005 ) Dopaminergic reinnervation of the globus pallidus by fetal nigral grafts in the rodent model of Parkinson’s disease. Cell Transplant. 14, 119 – 127. | en_US |
dc.identifier.citedreference | Bergson C., Mrzljak L., Smiley J. F., Pappy M., Levenson R. and Goldman‐Rakic P. S. ( 1995 ) Regional, cellular, and subcellular variations in the distribution of D 1 and D 5 dopamine receptors in primate brain. J. Neurosci. 15, 7821 – 7836. | en_US |
dc.identifier.citedreference | Bouali‐Benazzouz R., Tai C. H., Chetrit J. and Benazzouz A. ( 2009 ) Intrapallidal injection of 6‐hydroxydopamine induced changes in dopamine innervation and neuronal activity of globus pallidus. Neuroscience 164, 588 – 596. | en_US |
dc.identifier.citedreference | Cameron D. L. and Williams J. T. ( 1993 ) Dopamine D 1 receptors facilitate transmitter release. Nature 366, 344 – 347. | en_US |
dc.identifier.citedreference | Carlson J. H., Bergstrom D. A. and Walters J. R. ( 1986 ) Neurophysiological evidence that D‐1 dopamine receptor blockade attenuates postsynaptic but not autoreceptor‐mediated effects of dopamine agonists. Eur. J. Pharmacol. 123, 237 – 251. | en_US |
dc.identifier.citedreference | Costall B., Naylor R. J. and Olley J. E. ( 1972 ) Catalepsy and circling behaviour after intracerebral injections of neuroleptic, cholinergic and anticholinergic agents into the caudate‐putamen, globus pallidus and substantia nigra of rat brain. Neuropharmacology 11, 645 – 663. | en_US |
dc.identifier.citedreference | Cuello A. C. and Paxinos G. ( 1978 ) Evidence for a long Leu‐enkephalin striopallidal pathway in rat brain. Nature 271, 178 – 180. | en_US |
dc.identifier.citedreference | Dewar D., Jenner P. and Marsden C. D. ( 1985 ) Behavioural effects in rats of unilateral and bilateral injections of opiate receptor agonists into the globus pallidus. Neuroscience 15, 41 – 46. | en_US |
dc.identifier.citedreference | Di Chiara G. and Imperato A. ( 1998 ) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc. Natl Acad. Sci. USA 85, 5274 – 5278. | en_US |
dc.identifier.citedreference | Dubois A., Savasta M., Curet O. and Scatton B. ( 1986 ) Autoradiographic distribution of the D 1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D 2 dopamine receptors. Neuroscience 19, 125 – 137. | en_US |
dc.identifier.citedreference | Durieux P. F., Bearzatto B., Guiducci S., Buch T., Waisman A., Zoli M., Schiffmann S. N. and de Kerchove d’Exaerde A. ( 2009 ) D 2 R striatopallidal neurons inhibit both locomotor and drug reward processes. Nat. Neurosci. 12, 393 – 395. | en_US |
dc.identifier.citedreference | Filion M., Tremblay L. and Bédard P. J. ( 1991 ) Effects of dopamine agonists on the spontaneous activity of globus pallidus neurons in monkeys with MPTP‐induced Parkinsonism. Brain Res. 547, 152 – 161. | en_US |
dc.identifier.citedreference | Floran B., Aceves J., Sierra A. and Martinez‐Fong D. ( 1990 ) Activation of D 1 dopamine receptors stimulates the release of GABA in the basal ganglia of the rat. Neurosci. Lett. 116, 136 – 140. | en_US |
dc.identifier.citedreference | Floran B., Floran L., Sierra A. and Aceves J. ( 1997 ) D 2 receptor‐mediated inhibition of GABA release by endogenous dopamine in the rat globus pallidus. Neurosci. Lett. 237, 1 – 4. | en_US |
dc.identifier.citedreference | Fuchs H. and Hauber W. ( 2004 ) Dopaminergic innervation of the rat globus pallidus characterized by microdialysis and immunohistochemistry. Exp. Brain Res. 154, 66 – 75. | en_US |
dc.identifier.citedreference | Fuchs H., Nagel J. and Hauber W. ( 2005 ) Effects of physiological and pharmacological stimuli on dopamine release in the rat globus pallidus. Neurochem. Int. 47, 474 – 481. | en_US |
dc.identifier.citedreference | Galvan A., Floran B., Erlij D. and Aceves J. ( 2001 ) Intrapallidal dopamine restores motor deficits induced by 6‐hydroxydopamine in the rat. J. Neural. Transm. 108, 153 – 166. | en_US |
dc.identifier.citedreference | Gasca‐Martinez D., Hernandez A., Sierra A., Valdiosera R., Anaya‐Martinez V., Floran B., Erlij D. and Aceves J. ( 2010 ) Dopamine inhibits GABA transmission from the globus pallidus to the thalamic reticular nucleus via presynaptic D4 receptors. Neuroscience 169, 1672 – 1681. | en_US |
dc.identifier.citedreference | Hauber W., Lutz S. and Münkle M. ( 1998 ) The effects of globus pallidus lesions on dopamine‐dependent motor behaviour in rats. Neuroscience 86, 147 – 157. | en_US |
dc.identifier.citedreference | Hauber W. and Lutz S. ( 1999 ) Dopamine D 1 or D 2 receptor blockade in the globus pallidus produces akinesia in the rat. Behav. Brain Res. 106, 143 – 150. | en_US |
dc.identifier.citedreference | Hauber W. and Fuchs H. ( 2000 ) Dopamine release in the rat globus pallidus characterised by in vivo microdialysis. Behav. Brain Res. 111, 39 – 44. | en_US |
dc.identifier.citedreference | Hooks M. S., Jones D. N., Justice J. B., Jr and Holtzman S. G. ( 1992 ) Naloxone reduces amphetamine‐induced stimulation of locomotor activity and in vivo dopamine release in the striatum and nucleus accumbens. Pharmacol. Biochem. Behav. 42, 765 – 770. | en_US |
dc.identifier.citedreference | Hurley M. J., Mash D. C. and Jenner P. ( 2001 ) Dopamine D(1) receptor expression in human basal ganglia and changes in Parkinson’s disease. Brain Res. Mol. Brain Res. 87, 271 – 279. | en_US |
dc.identifier.citedreference | Joyce E. M., Koob G. F., Strecker R., Iversen S. D. and Bloom F. E. ( 1981 ) The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus. Brain Res. 221, 359 – 370. | en_US |
dc.identifier.citedreference | Jutkiewicz E. M., Torregrossa M. M., Sobczyk‐Kojiro K., Mosberg H. I., Folk J. E., Rice K. C., Watson S. J. and Woods J. H. ( 2006 ) Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects. Eur. J. Pharmacol. 531, 151 – 159. | en_US |
dc.identifier.citedreference | Kebabian J. W. and Calne D. B. ( 1979 ) Multiple receptors for dopamine. Nature 277, 93 – 96 (review). | en_US |
dc.identifier.citedreference | Kita H. and Kitai S. T. ( 1988 ) Glutamate decarboxylase immunoreactive neurons in rat neostriatum: their morphological types and populations. Brain Res. 447, 346 – 352. | en_US |
dc.identifier.citedreference | König M., Zimmer A. M., Steiner H., Holmes P. V., Crawley J. N., Brownstein M. J. and Zimmer A. ( 1996 ) Pain responses, anxiety and aggression in mice deficient in pre‐proenkephalin. Nature 383, 535 – 538. | en_US |
dc.identifier.citedreference | Li Q., Zubieta J. K. and Kennedy R. T. ( 2009 ) Practical aspects of in vivo detection of neuropeptides by microdialysis coupled off‐line to capillary LC with multistage MS. Anal. Chem. 81, 2242 – 2250. | en_US |
dc.identifier.citedreference | Lindvall O. and Björklund A. ( 1979 ) Dopaminergic innervation of the globus pallidus by collaterals from the nigrostriatal pathway. Brain Res. 172, 169 – 173. | en_US |
dc.identifier.citedreference | Ludwig M. and Leng G. ( 2006 ) Dendritic peptide release and peptide‐dependent behaviours. Nat. Rev. Neurosci. 7, 126 – 136 (review). | en_US |
dc.identifier.citedreference | Mabrouk O. S., Volta M., Marti M. and Morari M. ( 2008 ) Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6‐hydroxydopamine lesioned rats: new insights into the role of delta receptors in Parkinsonism. J. Neurochem. 107, 1647 – 1659. | en_US |
dc.identifier.citedreference | Maneuf Y. P., Mitchell I. J., Crossman A. R. and Brotchie J. M. ( 1994 ) On the role of enkephalin cotransmission in the GABAergic striatal efferents to the globus pallidus. Exp. Neurol. 125, 65 – 71. | en_US |
dc.identifier.citedreference | Mansour A., Meador‐Woodruff J. H., Bunzow J. R., Civelli O., Akil H. and Watson S. J. ( 1990 ) Localization of dopamine D 2 receptor mRNA and D 1 and D 2 receptor binding in the rat brain and pituitary: an in situ hybridization‐receptor autoradiographic analysis. J. Neurosci. 10, 2587 – 2600. | en_US |
dc.identifier.citedreference | Marshall J. F., Henry B. L., Billings L. M. and Hoover B. R. ( 2001 ) The role of the globus pallidus D 2 subfamily of dopamine receptors in pallidal immediate early gene expression. Neuroscience 105, 365 – 378. | en_US |
dc.identifier.citedreference | Michael‐Titus A., Preterre P., Giros B and Costentin J. ( 1987 ) Role of endogenous enkephalins in locomotion evidenced by acetorphan, an “enkephalinase” inhibitor. J. Pharmacol. Exp. Ther. 243, 1062 – 1066. | en_US |
dc.identifier.citedreference | Olive M. F., Anton B., Micevych P., Evans C. J. and Maidment N. T. ( 1997 ) Presynaptic versus postsynaptic localization of mu and delta opioid receptors in dorsal and ventral striatopallidal pathways. J. Neurosci. 17, 7471 – 7479. | en_US |
dc.identifier.citedreference | Ossowska K., Wedzony K. and Wolfarth S. ( 1984 ) The role of the GABA mechanisms of the globus pallidus in mediating catalepsy, stereotypy and locomotor activity. Pharmacol. Biochem. Behav. 21, 825 – 831. | en_US |
dc.identifier.citedreference | Parent A. and Hazrati L. N. ( 1995a ) Functional anatomy of the basal ganglia. I. The cortico‐basal ganglia‐thalamo‐cortical loop. Brain Res. Brain Res. Rev. 20, 91 – 127. | en_US |
dc.identifier.citedreference | Parent A. and Hazrati L. N. ( 1995b ) Functional anatomy of the basal ganglia. II. The place of subthalamic nucleus and external pallidum in basal ganglia circuitry. Brain Res. Brain Res. Rev. 20, 128 – 154. | en_US |
dc.identifier.citedreference | Paxinos G. and Watson C. ( 2007 ) The Rat Brain in Stereotaxic Coordinates, 6th edn. Academic Press, Amsterdam. | en_US |
dc.identifier.citedreference | Schad C. A., Justice J. B., Jr and Holtzman S. G. ( 1995 ) Naloxone reduces the neurochemical and behavioral effects of amphetamine but not those of cocaine. Eur. J. Pharmacol. 275, 9 – 16. | en_US |
dc.identifier.citedreference | Shin R. M., Masuda M., Miura M., Sano H., Shirasawa T., Song W. J., Kobayashi K. and Aosaki T. ( 2003 ) Dopamine D 4 receptor‐induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. J. Neurosci. 23, 11662 – 11672. | en_US |
dc.identifier.citedreference | Stanford I. M. and Cooper A. J. ( 1999 ) Presynaptic mu and delta opioid receptor modulation of GABAA IPSCs in the rat globus pallidus in vitro. J. Neurosci. 19, 4796 – 4803. | en_US |
dc.identifier.citedreference | Walters J. R., Bergstrom D. A., Carlson J. H., Chase T. N. and Braun A. R. ( 1987 ) D 1 dopamine receptor activation required for postsynaptic expression of D 2 agonist effects. Science 236, 719 – 722. | en_US |
dc.identifier.citedreference | Wang J. Q. and McGinty J. F. ( 1996 ) D 1 and D 2 receptor regulation of preproenkephalin and preprodynorphin mRNA in rat striatum following acute injection of amphetamine or methamphetamine. Synapse 22, 114 – 122. | en_US |
dc.identifier.citedreference | Yung K. K., Bolam J. P., Smith A. D., Hersch S. M., Ciliax B. J. and Levey A. I. ( 1995 ) Immunocytochemical localization of D 1 and D 2 dopamine receptors in the basal ganglia of the rat: light and electron microscopy. Neuroscience 65, 709 – 730. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.