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Hepatocyte growth factor–regulated tyrosine kinase substrate ( Hgs ) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryo
dc.contributor.authorMiura, Shigetoen_US
dc.contributor.authorMishina, Yujien_US
dc.date.accessioned2011-11-10T15:35:51Z
dc.date.available2013-01-02T16:32:25Zen_US
dc.date.issued2011-11en_US
dc.identifier.citationMiura, Shigeto; Mishina, Yuji (2011). "Hepatocyte growth factor–regulated tyrosine kinase substrate ( Hgs ) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryo." Developmental Dynamics 240(11): 2474-2481. <http://hdl.handle.net/2027.42/87001>en_US
dc.identifier.issn1058-8388en_US
dc.identifier.issn1097-0177en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/87001
dc.description.abstractHepatocyte growth factor–regulated tyrosine kinase substrate that is encoded by Hgs promotes degradation of ubiquitinated signaling molecule in the early endosome. We previously reported that a targeted mutation in Hgs results in embryonic lethality soon after gastrulation in the mouse. Here, we report that downstream target genes for BMP signaling were highly down‐regulated in the Hgs mutant embryos. We also showed that Hgs is required for phosphorylation of SMAD1/5/8 and TAK1/p38 to transduce BMP signaling. Furthermore, we found that HGS functions to localize TAK1 in early endosome for its activation. These results suggest that HGS is critical to localize TAK1 to early endosome for transducing BMP signaling for proper development. Our data revealed a new mechanism to modify BMP signaling by Hgs during early mouse development. Developmental Dynamics 240:2474–2481, 2011. © 2011 Wiley‐Liss, Inc.en_US
dc.publisherWiley‐Liss, Inc.en_US
dc.subject.otherGastrulationen_US
dc.subject.otherSignal Transductionen_US
dc.subject.otherEndosomeen_US
dc.titleHepatocyte growth factor–regulated tyrosine kinase substrate ( Hgs ) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryoen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109‐1078en_US
dc.contributor.affiliationotherLaboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolinaen_US
dc.identifier.pmid21953618en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/87001/1/22750_ftp.pdf
dc.identifier.doi10.1002/dvdy.22750en_US
dc.identifier.sourceDevelopmental Dynamicsen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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