Invasive disease caused by Haemophilus influenzae in Sweden 1997–2009; evidence of increasing incidence and clinical burden of non‐type b strains
dc.contributor.author | Resman, F. | en_US |
dc.contributor.author | Ristovski, M. | en_US |
dc.contributor.author | Ahl, J. | en_US |
dc.contributor.author | Forsgren, A. | en_US |
dc.contributor.author | Gilsdorf, Janet R. | en_US |
dc.contributor.author | Jasir, A. | en_US |
dc.contributor.author | Kaijser, B. | en_US |
dc.contributor.author | Kronvall, G. | en_US |
dc.contributor.author | Riesbeck, K. | en_US |
dc.date.accessioned | 2011-11-10T15:37:11Z | |
dc.date.available | 2013-01-02T16:32:30Z | en_US |
dc.date.issued | 2011-11 | en_US |
dc.identifier.citation | Resman, F.; Ristovski, M.; Ahl, J.; Forsgren, A.; Gilsdorf, J. R.; Jasir, A.; Kaijser, B.; Kronvall, G.; Riesbeck, K. (2011). "Invasive disease caused by Haemophilus influenzae in Sweden 1997–2009; evidence of increasing incidence and clinical burden of non‐type b strains." Clinical Microbiology and Infection 17(11). <http://hdl.handle.net/2027.42/87052> | en_US |
dc.identifier.issn | 1198-743X | en_US |
dc.identifier.issn | 1469-0691 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/87052 | |
dc.description.abstract | Introduction of a conjugated vaccine against encapsulated Haemophilus influenzae type b (Hib) has led to a dramatic reduction of invasive Hib disease. However, an increasing incidence of invasive disease by H. influenzae non‐type b has recently been reported. Non‐type b strains have been suggested to be opportunists in an invasive context, but information on clinical consequences and related medical conditions is scarce. In this retrospective study, all H. influenzae isolates ( n = 410) from blood and cerebrospinal fluid in three metropolitan Swedish regions between 1997 and 2009 from a population of approximately 3 million individuals were identified. All available isolates were serotyped by PCR ( n = 250). We observed a statistically significant increase in the incidence of invasive H. influenzae disease, ascribed to non‐typeable H. influenzae (NTHi) and encapsulated strains type f (Hif) in mainly individuals >60 years of age. The medical reports from a subset of 136 cases of invasive Haemophilus disease revealed that 48% of invasive NTHi cases and 59% of invasive Hif cases, respectively, met the criteria of severe sepsis or septic shock according to the ACCP/SCCM classification of sepsis grading. One‐fifth of invasive NTHi cases and more than one‐third of invasive Hif cases were admitted to intensive care units. Only 37% of patients with invasive non‐type b disease had evidence of immunocompromise, of which conditions related to impaired humoral immunity was the most common. The clinical burden of invasive non‐type b H. influenzae disease, measured as days of hospitalization/100 000 individuals at risk and year, increased significantly throughout the study period. | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Haemophilus Influenzae | en_US |
dc.subject.other | Hib | en_US |
dc.subject.other | Hif | en_US |
dc.subject.other | Invasive Disease | en_US |
dc.subject.other | Meningitis | en_US |
dc.subject.other | Sepsis | en_US |
dc.title | Invasive disease caused by Haemophilus influenzae in Sweden 1997–2009; evidence of increasing incidence and clinical burden of non‐type b strains | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Medical Microbiology, Department of Laboratory Medicine | en_US |
dc.contributor.affiliationother | Infectious Diseases, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden | en_US |
dc.contributor.affiliationother | Department of Clinical Microbiology and Immunology, Lund University, Skåne University Hospital, Lund | en_US |
dc.contributor.affiliationother | Department of Clinical Bacteriology, Gothenburg University, Gothenburg | en_US |
dc.contributor.affiliationother | Clinical Microbiology—MTC, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden | en_US |
dc.identifier.pmid | 21054663 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/87052/1/j.1469-0691.2010.03417.x.pdf | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/87052/2/CLM_3417_sm_FigS1.pdf | |
dc.identifier.doi | 10.1111/j.1469-0691.2010.03417.x | en_US |
dc.identifier.source | Clinical Microbiology and Infection | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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