Cation and anion transport through hydrophilic pores in lipid bilayers
dc.contributor.author | Kandasamy, Senthil K. | en_US |
dc.contributor.author | Larson, Ronald G. | en_US |
dc.date.accessioned | 2011-11-15T16:10:27Z | |
dc.date.available | 2011-11-15T16:10:27Z | |
dc.date.issued | 2006-08-21 | en_US |
dc.identifier.citation | Kandasamy, Senthil K.; Larson, Ronald G. (2006). "Cation and anion transport through hydrophilic pores in lipid bilayers." The Journal of Chemical Physics 125(7): 074901-074901-9. <http://hdl.handle.net/2027.42/87872> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/87872 | |
dc.description.abstract | To understand the origin of transmembrane potentials, formation of transient pores, and the movement of anions and cations across lipid membranes, we have performed systematic atomistic molecular dynamics simulations of palmitoyl-oleoyl-phosphatidylcholine (POPC) lipids. A double bilayer setup was employed and different transmembrane potentials were generated by varying the anion (Cl−)(Cl−) and cation (Na+)(Na+) concentrations in the two water compartments. A transmembrane potential of ∼ 350 mV∼350mV was thereby generated per bilayer for a unit charge imbalance. For transmembrane potential differences of up to ∼ 1.4 V∼1.4V, the bilayers were stable, over the time scale of the simulations (10–50 ns)(10–50ns). At larger imposed potential differences, one of the two bilayers breaks down through formation of a water pore, leading to both anion and cation translocations through the pore. The anions typically have a short residence time inside the pore, while the cations show a wider range of residence times depending on whether they bind to a lipid molecule or not. Over the time scale of the simulations, we do not observe the discharge of the entire potential difference, nor do we observe pore closing, although we observe that the size of the pore decreases as more ions translocate. We also observed a rare lipid flip-flop, in which a lipid molecule translocated from one bilayer leaflet to the opposite leaflet, assisted by the water pore. | en_US |
dc.publisher | The American Institute of Physics | en_US |
dc.rights | © The American Institute of Physics | en_US |
dc.title | Cation and anion transport through hydrophilic pores in lipid bilayers | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Chemical Engineering Department, The University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.identifier.pmid | 16942374 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/87872/2/074901_1.pdf | |
dc.identifier.doi | 10.1063/1.2217737 | en_US |
dc.identifier.source | The Journal of Chemical Physics | en_US |
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