Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study
dc.contributor.author | Sánchez, Elena | en_US |
dc.contributor.author | Comeau, Mary E. | en_US |
dc.contributor.author | Freedman, Barry I. | en_US |
dc.contributor.author | Kelly, Jennifer A. | en_US |
dc.contributor.author | Kaufman, Kenneth M. | en_US |
dc.contributor.author | Langefeld, Carl D. | en_US |
dc.contributor.author | Brown, Elizabeth E. | en_US |
dc.contributor.author | Alarcón, Graciela S. | en_US |
dc.contributor.author | Kimberly, Robert P. | en_US |
dc.contributor.author | Edberg, Jeffrey C. | en_US |
dc.contributor.author | Ramsey‐goldman, Rosalind | en_US |
dc.contributor.author | Petri, Michelle A. | en_US |
dc.contributor.author | Reveille, John D. | en_US |
dc.contributor.author | Vilá, Luis M. | en_US |
dc.contributor.author | Merrill, Joan T. | en_US |
dc.contributor.author | Tsao, Betty P. | en_US |
dc.contributor.author | Kamen, Diane L. | en_US |
dc.contributor.author | Gilkeson, Gary S. | en_US |
dc.contributor.author | James, Judith A. | en_US |
dc.contributor.author | Vyse, Timothy J. | en_US |
dc.contributor.author | Gaffney, Patrick M. | en_US |
dc.contributor.author | Jacob, Chaim O. | en_US |
dc.contributor.author | Niewold, Timothy B. | en_US |
dc.contributor.author | Richardson, Bruce C. | en_US |
dc.contributor.author | Harley, John B. | en_US |
dc.contributor.author | Alarcón‐riquelme, Marta E. | en_US |
dc.contributor.author | Sawalha, Amr H. | en_US |
dc.date.accessioned | 2011-12-05T18:32:33Z | |
dc.date.available | 2013-01-02T16:32:44Z | en_US |
dc.date.issued | 2011-11 | en_US |
dc.identifier.citation | Sánchez, Elena ; Comeau, Mary E.; Freedman, Barry I.; Kelly, Jennifer A.; Kaufman, Kenneth M.; Langefeld, Carl D.; Brown, Elizabeth E.; Alarcón, Graciela S. ; Kimberly, Robert P.; Edberg, Jeffrey C.; Ramsey‐goldman, Rosalind ; Petri, Michelle; Reveille, John D.; Vilá, Luis M. ; Merrill, Joan T.; Tsao, Betty P.; Kamen, Diane L.; Gilkeson, Gary S.; James, Judith A.; Vyse, Timothy J.; Gaffney, Patrick M.; Jacob, Chaim O.; Niewold, Timothy B.; Richardson, Bruce C.; Harley, John B.; Alarcón‐riquelme, Marta E. ; Sawalha, Amr H. (2011). "Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study." Arthritis & Rheumatism 63(11): 3493-3501. <http://hdl.handle.net/2027.42/88030> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/88030 | |
dc.description.abstract | Objective Candidate gene and genome‐wide association studies have identified several disease susceptibility loci in lupus patients. These studies have largely been performed in lupus patients who are Asian or of European ancestry. This study was undertaken to examine whether some of these same susceptibility loci increase lupus risk in African American individuals. Methods Single‐nucleotide polymorphisms tagging 15 independent lupus susceptibility loci were genotyped in a set of 1,724 lupus patients and 2,024 healthy controls of African American descent. The loci examined included PTPN22 , FCGR2A , TNFSF4 , STAT4 , CTLA4 , PDCD1 , PXK , BANK1 , MSH5 (HLA region), CFB (HLA region), C8orf13‐BLK region, MBL2 , KIAA1542 , ITGAM , and MECP2 / IRAK1 . Results We found the first evidence of genetic association between lupus in African American patients and 5 susceptibility loci ( C8orf13‐BLK , BANK1 , TNFSF4 , KIAA1542 , and CTLA4 ; P = 8.0 × 10 −6 , P = 1.9 × 10 −5 , P = 5.7 × 10 −5 , P = 0.00099, and P = 0.0045, respectively). Further, we confirmed the genetic association between lupus and 5 additional lupus susceptibility loci ( ITGAM , MSH5 , CFB , STAT4 , and FCGR2A ; P = 7.5 × 10 −11 , P = 5.2 × 10 −8 , P = 8.7 × 10 −7 , P = 0.0058, and P = 0.0070, respectively), and provided evidence, for the first time, of genome‐wide significance for the association between lupus in African American patients and ITGAM and MSH5 (HLA region). Conclusion These findings provide evidence of novel genetic susceptibility loci for lupus in African Americans and demonstrate that the majority of lupus susceptibility loci examined confer lupus risk across multiple ethnicities. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.title | Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan and Ann Arbor VA Medical Center, Ann Arbor | en_US |
dc.contributor.affiliationother | Oklahoma Medical Research Foundation, Oklahoma City | en_US |
dc.contributor.affiliationother | Wake Forest University Health Sciences, Winston‐Salem, North Carolina | en_US |
dc.contributor.affiliationother | Wake Forest University School of Medicine, Winston‐Salem, North Carolina | en_US |
dc.contributor.affiliationother | Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, and Oklahoma City VA Medical Center, Oklahoma City | en_US |
dc.contributor.affiliationother | University of Alabama at Birmingham | en_US |
dc.contributor.affiliationother | Northwestern University Feinberg School of Medicine, Chicago, Illinois | en_US |
dc.contributor.affiliationother | Johns Hopkins University School of Medicine, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | University of Texas Health Science Center at Houston | en_US |
dc.contributor.affiliationother | University of Puerto Rico School of Medicine, San Juan, Puerto Rico | en_US |
dc.contributor.affiliationother | Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, Oklahoma City | en_US |
dc.contributor.affiliationother | University of California, Los Angeles | en_US |
dc.contributor.affiliationother | Medical University of South Carolina, Charleston | en_US |
dc.contributor.affiliationother | King's College London and Guy's Hospital, London, UK | en_US |
dc.contributor.affiliationother | University of Southern California, Los Angeles | en_US |
dc.contributor.affiliationother | University of Chicago, Chicago, Illinois | en_US |
dc.contributor.affiliationother | Cincinnati Children's Hospital Medical Center and Cincinnati VA Medical Center, Cincinnati, Ohio | en_US |
dc.contributor.affiliationother | Oklahoma Medical Research Foundation, Oklahoma City, and Pfizer–University of Granada–Junta de Andalucia, Granada, Spain | en_US |
dc.contributor.affiliationother | Oklahoma Medical Research Foundation, 825 NE 13th Street, MS#24, Oklahoma City, OK 73104 | en_US |
dc.identifier.pmid | 21792837 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/88030/1/30563_ftp.pdf | |
dc.identifier.doi | 10.1002/art.30563 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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