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Artificial feeding synchronizes behavioral, hormonal, metabolic and neural parameters in mother‐deprived neonatal rabbit pups
dc.contributor.authorMorgado, Elviraen_US
dc.contributor.authorJuárez, Claudiaen_US
dc.contributor.authorMelo, Angel I.en_US
dc.contributor.authorDomínguez, Belisarioen_US
dc.contributor.authorLehman, Michael N.en_US
dc.contributor.authorEscobar, Carolinaen_US
dc.contributor.authorMeza, Enriqueen_US
dc.contributor.authorCaba, Marioen_US
dc.date.accessioned2011-12-05T18:34:32Z
dc.date.available2013-02-01T20:26:19Zen_US
dc.date.issued2011-12en_US
dc.identifier.citationMorgado, Elvira; Juárez, Claudia ; Melo, Angel I.; Domínguez, Belisario ; Lehman, Michael N.; Escobar, Carolina; Meza, Enrique; Caba, Mario (2011). "Artificial feeding synchronizes behavioral, hormonal, metabolic and neural parameters in motherâ deprived neonatal rabbit pups." European Journal of Neuroscience 34(11). <http://hdl.handle.net/2027.42/88087>en_US
dc.identifier.issn0953-816Xen_US
dc.identifier.issn1460-9568en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/88087
dc.description.abstractNursing in the rabbit is under circadian control, and pups have a daily anticipatory behavioral arousal synchronized to this unique event, but it is not known which signal is the main entraining cue. In the present study, we hypothesized that food is the main entraining signal. Using mother‐deprived pups, we tested the effects of artificial feeding on the synchronization of locomotor behavior, plasma glucose, corticosterone, c‐Fos (FOS) and PERIOD1 (PER1) rhythms in suprachiasmatic, supraoptic, paraventricular and tuberomammillary nuclei. At postnatal day 1, an intragastric tube was placed by gastrostomy. The next day and for the rest of the experiment, pups were fed with a milk formula through the cannula at either 02:00 h or 10:00 h [feeding time = zeitgeber time (ZT)0]. At postnatal days 5–7, pups exhibited behavioral arousal, with a significant increase in locomotor behavior 60 min before feeding. Glucose levels increased after feeding, peaking at ZT4–ZT12 and then declining. Corticosterone levels were highest around the time of feeding, and then decreased to trough concentrations at ZT12–ZT16, increasing again in anticipation of the next feeding bout. In the brain, the suprachiasmatic nucleus had a rhythm of FOS and PER1 that was not significantly affected by the feeding schedule. Conversely, the supraoptic, paraventricular and tuberomammillary nuclei had rhythms of both FOS and PER1 induced by the time of scheduled feeding. We conclude that the nursing rabbit pup is a natural model of food entrainment, as food, in this case milk formula, is a strong synchronizing signal for behavioral, hormonal, metabolic and neural parameters. Nursing in the rabbit is under circadian control, and pups have a daily anticipatory behavioral arousal synchronized to this unique event, but it is not known which signal is the main entraining cue. In the present study, we hypothesized that food is the main entraining signal.en_US
dc.publisherBlackwell Publishing Ltden_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherAnticipatory Arousalen_US
dc.subject.otherClock Genesen_US
dc.subject.otherCorticosteroneen_US
dc.subject.otherFOSen_US
dc.subject.otherSynchronization by Fooden_US
dc.titleArtificial feeding synchronizes behavioral, hormonal, metabolic and neural parameters in mother‐deprived neonatal rabbit pupsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Molecular & Integrative Physiology, and Reproductive Sciences Program, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherCentro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa, Ver., Méxicoen_US
dc.contributor.affiliationotherCIRA, CINVESTAV‐UAT, Tlaxcala, Tlax., Méxicoen_US
dc.contributor.affiliationotherFacultad Medicina Veterinaria y Zootecnia, Universidad Veracruzana, Veracruz Ver., Méxicoen_US
dc.contributor.affiliationotherDepartamento de Anatomía, Facultad de Medicina, UNAM, México D.F., Méxicoen_US
dc.identifier.pmid22098455en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/88087/1/j.1460-9568.2011.07898.x.pdf
dc.identifier.doi10.1111/j.1460-9568.2011.07898.xen_US
dc.identifier.sourceEuropean Journal of Neuroscienceen_US
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