View Item 

Show simple item record

Electron detachment dissociation of fluorescently labeled sialylated oligosaccharides
dc.contributor.authorMechref, Yehiaen_US
dc.date.accessioned2012-01-05T22:07:41Z
dc.date.available2013-02-01T20:26:15Zen_US
dc.date.issued2011-12en_US
dc.identifier.citationMechref, Yehia (2011). "Electron detachment dissociation of fluorescently labeled sialylated oligosaccharides ." ELECTROPHORESIS 32(24): 3526-3535. <http://hdl.handle.net/2027.42/89573>en_US
dc.identifier.issn0173-0835en_US
dc.identifier.issn1522-2683en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/89573
dc.description.abstractWe explored the application of electron detachment dissociation (EDD) and infrared multiphoton dissociation (IRMPD) tandem mass spectrometry to fluorescently labeled sialylated oligosaccharides. Standard sialylated oligosaccharides and a sialylated N ‐linked glycan released from human transferrin were investigated. EDD yielded extensive glycosidic cleavages and cross‐ring cleavages in all cases studied, consistently providing complementary structural information compared with infrared multiphoton dissociation. Neutral losses and satellite ions such as C−2H ions were also observed following EDD. In addition, we examined the influence of different fluorescent labels. The acidic label 2‐aminobenzoic acid (2‐AA) enhanced signal abundance in negative‐ion mode. However, few cross‐ring fragments were observed for 2‐AA‐labeled oligosaccharides. The neutral label 2‐aminobenzamide (2‐AB) resulted in more cross‐ring cleavages compared with 2‐AA‐labeled species, but not as extensive fragmentation as for native oligosaccharides, likely resulting from altered negative charge locations from introduction of the fluorescent tag.en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.subject.otherDerivatized Oligosaccharidesen_US
dc.subject.otherFourier Transform Ion Cyclotron Resonance Mass Spectrometryen_US
dc.subject.otherHigh Resolutionen_US
dc.subject.otherStructural Characterizationen_US
dc.subject.otherTandem Mass Spectrometryen_US
dc.titleElectron detachment dissociation of fluorescently labeled sialylated oligosaccharidesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelMaterials Science and Engineeringen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Chemistry, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109‐1055, USA Fax: +1‐734‐615‐3790en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/89573/1/elps_201100327_sm_SupplInfo.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/89573/2/3526_ftp.pdf
dc.identifier.doi10.1002/elps.201100327en_US
dc.identifier.sourceELECTROPHORESISen_US
dc.identifier.citedreferenceVarki, A., Glycobiology 1993, 3, 97 – 130.en_US
dc.identifier.citedreferenceKim, Y. J., Varki, A., Glycoconj. J. 1997, 14, 569 – 576.en_US
dc.identifier.citedreferenceRaman, R., Raguram, S., Venkataraman, G., Paulson, J. C., Sasisekharan, R., Nat. Methods 2005, 2, 817 – 824.en_US
dc.identifier.citedreferenceDube, D. H., Bertozzi, C. R., Nat. Rev. Drug Discov. 2005, 4, 477 – 488.en_US
dc.identifier.citedreferenceBertozzi, C. R., Kiessling, L. L., Science 2001, 291, 2357 – 2364.en_US
dc.identifier.citedreferenceFinkelstein, J., Nature 2007, 446, 999.en_US
dc.identifier.citedreferenceVarki, A., Nature 2007, 446, 1023 – 1029.en_US
dc.identifier.citedreferenceMorelle, W., Michalski, J. C., Curr. Pharm. Des. 2005, 11, 2615 – 2645.en_US
dc.identifier.citedreferenceZaia, J., Chem. Biol. 2008, 15, 881 – 892.en_US
dc.identifier.citedreferenceKrishnamoorthy, L., Mahal, L. K., ACS Chem. Biol. 2009, 4, 715 – 732.en_US
dc.identifier.citedreferenceMechref, Y., Novotny, M. V., Chem. Rev. 2002, 102, 321 – 369.en_US
dc.identifier.citedreferenceMarshall, A. G., Hendrickson, C. L., Jackson, G. S., Mass Spectrom. Rev. 1998, 17, 1 – 35.en_US
dc.identifier.citedreferencePark, Y. M., Lebrilla, C. B., Mass Spectrom. Rev. 2005, 24, 232 – 264.en_US
dc.identifier.citedreferenceMarshall, A. G., Hendrickson, C. L., Annu. Rev. Anal. Chem. 2008, 1, 579 – 599.en_US
dc.identifier.citedreferenceHarvey, D. J., J. Mass Spectrom. 2005, 40, 642 – 653.en_US
dc.identifier.citedreferenceSagi, D., Peter‐Katalinic, J., Conradt, H. S., Nimtz, M., J. Am. Soc. Mass. Spectrom. 2002, 13, 1138 – 1148.en_US
dc.identifier.citedreferenceZaia, J., Miller, M. J. C., Seymour, J. L., Costello, C. E., J. Am. Soc. Mass. Spectrom. 2007, 18, 952 – 960.en_US
dc.identifier.citedreferenceLancaster, K. S., An, H. J., Li, B. S., Lebrilla, C. B., Anal. Chem. 2006, 78, 4990 – 4997.en_US
dc.identifier.citedreferenceXie, Y. M., Lebrilla, C. B., Anal. Chem. 2003, 75, 1590 – 1598.en_US
dc.identifier.citedreferenceZhang, J. H., Schubothe, K., Li, B. S., Russell, S., Lebrilla, C. B., Anal. Chem. 2005, 77, 208 – 214.en_US
dc.identifier.citedreferenceHarvey, D. J., Naven, T. J. P., Kuster, B., Bateman, R. H., Green, M. R., Critchley, G., Rapid Commun. Mass Spectrom. 1995, 9, 1556 – 1561.en_US
dc.identifier.citedreferenceHarvey, D. J., Bateman, R. H., Green, M. R., J. Mass Spectrom. 1997, 32, 167 – 187.en_US
dc.identifier.citedreferenceLewandrowski, U., Resemann, A., Sickmann, A., Anal. Chem. 2005, 77, 3274 – 3283.en_US
dc.identifier.citedreferenceZhao, C., Xie, B., Chan, S. Y., Costello, C. E., O'Connor, P. B., J. Am. Soc. Mass. Spectrom. 2008, 19, 138 – 150.en_US
dc.identifier.citedreferenceAdamson, J. T., Håkansson, K., Anal. Chem. 2007, 79, 2901 – 2910.en_US
dc.identifier.citedreferenceBudnik, B. A., Haselmann, K. F., Elkin, Y. N., Gorbach, V. I., Zubarev, R. A., Anal. Chem. 2003, 75, 5994 – 6001.en_US
dc.identifier.citedreferenceMcFarland, M. A., Marshall, A. G., Hendrickson, C. L., Nilsson, C. L., Fredman, P., Mansson, J. E., J. Am. Soc. Mass. Spectrom. 2005, 16, 752 – 762.en_US
dc.identifier.citedreferenceLiu, H., Håkansson, K., Int. J. Mass Spectrom. 2011 in press, doi: 10.1016/j.ijms.2010.10.030.en_US
dc.identifier.citedreferenceWolff, J. J., Chi, L. L., Linhardt, R. J., Amster, I. J., Anal. Chem. 2007, 79, 2015 – 2022.en_US
dc.identifier.citedreferenceWolff, J. J., Laremore, T. N., Busch, A. M., Linhardt, R. J., Amster, I. J., J. Am. Soc. Mass. Spectrom. 2008, 19, 294 – 304.en_US
dc.identifier.citedreferenceWolff, J. J., Laremore, T. N., Busch, A. M., Linhardt, R. J., Amster, I. J., J. Am. Soc. Mass. Spectrom. 2008, 19, 790 – 798.en_US
dc.identifier.citedreferenceWolff, J. J., Amster, I. J., Chi, L. L., Linhardt, R. J., J. Am. Soc. Mass. Spectrom. 2007, 18, 234 – 244.en_US
dc.identifier.citedreferenceWolff, J. J., Laremore, T. N., Leach, F. E., Linhardt, R. J., Amster, I. J., Eur. J. Mass Spectrom. 2009, 15, 275 – 281.en_US
dc.identifier.citedreferenceAdamson, J. T., Håkansson, K., J. Am. Soc. Mass. Spectrom. 2007, 18, 2162 – 2172.en_US
dc.identifier.citedreferenceWolff, J. J., Leach, F. E., Laremore, T. N., Kaplan, D. A., Easterling, M. L., Linhardt, R. J., Amster, I. J., Anal. Chem. 2010, 82, 3460 – 3466.en_US
dc.identifier.citedreferenceDevakumar, A., Thompson, M. S., Reilly, J. P., Rapid Commun. Mass Spectrom. 2005, 19, 2313 – 2320.en_US
dc.identifier.citedreferenceDevakumar, A., Mechref, Y., Kang, P., Novotny, M. V., Reilly, J. P., J. Am. Soc. Mass. Spectrom. 2008, 19, 1027 – 1040.en_US
dc.identifier.citedreferenceDevakumar, A., Mechref, Y., Kang, P., Novotny, M. V., Reilly, J. P., Rapid Commun. Mass Spectrom. 2007, 21, 1452 – 1460.en_US
dc.identifier.citedreferenceGao, D., Zhou, W., Håkansson, K., 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah 2010.en_US
dc.identifier.citedreferenceBrodbelt, J. S., Wilson, J. J., Mass Spectrom. Rev. 2009, 28, 390 – 424.en_US
dc.identifier.citedreferenceEyler, J. R., Mass Spectrom. Rev. 2009, 28, 448 – 467.en_US
dc.identifier.citedreferenceBudnik, B. A., Haselmann, K. F., Zubarev, R. A., Chem. Phys. Lett. 2001, 342, 299 – 302.en_US
dc.identifier.citedreferenceZubarev, R. A., Mass Spectrom. Rev. 2003, 22, 57 – 77.en_US
dc.identifier.citedreferenceZhou, W., Håkansson, K., 57th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, PA 2009.en_US
dc.identifier.citedreferenceWolff, J. J., Laremore, T. N., Aslam, H., Linhardt, R. J., Amster, I. J., J. Am. Soc. Mass. Spectrom. 2008, 19, 1449 – 1458.en_US
dc.identifier.citedreferenceYoshino, K., Takao, T., Murata, H., Shimonishi, Y., Anal. Chem. 1995, 67, 4028 – 4031.en_US
dc.identifier.citedreferenceLamari, F. N., Kuhn, R., Karamanos, N. K., J. Chromatogr. B 2003, 793, 15 – 36.en_US
dc.identifier.citedreferenceLattova, E., Snovida, S., Perreault, H., Krokhin, O., J. Am. Soc. Mass Spectrom. 2005, 16, 683 – 696.en_US
dc.identifier.citedreferenceAnumula, K. R., Anal. Biochem. 2006, 350, 1 – 23.en_US
dc.identifier.citedreferenceRuhaak, L. R., Zauner, G., Huhn, C., Bruggink, C., Deelder, A. M., Wuhrer, M., Anal. Bioanal. Chem. 2010, 397, 3457 – 3481.en_US
dc.identifier.citedreferenceWuhrer, M., Deelder, A. M., Hokke, C. H., J. Chromatogr. B 2005, 825, 124 – 133.en_US
dc.identifier.citedreferenceBowman, M. J., Zaia, J., Anal. Chem. 2007, 79, 5777 – 5784.en_US
dc.identifier.citedreferenceXia, B. Y., Feasley, C. L., Sachdev, G. P., Smith, D. F., Cummings, R. D., Anal. Biochem. 2009, 387, 162 – 170.en_US
dc.identifier.citedreferencePrien, J. M., Prater, B. D., Qin, Q., Cockrill, S. L., Anal. Chem. 2010, 82, 1498 – 1508.en_US
dc.identifier.citedreferenceBigge, J. C., Patel, T. P., Bruce, J. A., Goulding, P. N., Charles, S. M., Parekh, R. B., Anal. Biochem. 1995, 230, 229 – 238.en_US
dc.identifier.citedreferenceMaslen, S., Sadowski, P., Adam, A., Lilley, K., Stephens, E., Anal. Chem. 2006, 78, 8491 – 8498.en_US
dc.identifier.citedreferenceMaslen, S. L., Goubet, F., Adam, A., Dupree, P., Stephens, E., Carbohydr. Res. 2007, 342, 724 – 735.en_US
dc.identifier.citedreferenceWuhrer, M., Koeleman, C. A. M., Deelder, A. M., Anal. Chem. 2009, 81, 4422 – 4432.en_US
dc.identifier.citedreferenceHarvey, D. J., Analyst 2000, 125, 609 – 617.en_US
dc.identifier.citedreferenceHarvey, D. J., J. Am. Soc. Mass Spectrom. 2000, 11, 900 – 915.en_US
dc.identifier.citedreferenceSato, Y., Suzuki, M., Nirasawa, T., Suzuki, A., Endo, T., Anal. Chem. 2000, 72, 1207 – 1216.en_US
dc.identifier.citedreferenceWuhrer, M., Koeleman, C. A. M., Hokke, C. H., Deelder, A. M., Int. J. Mass Spectrom. 2004, 232, 51 – 57.en_US
dc.identifier.citedreferenceWuhrer, M., Deelder, A. M., Anal. Chem. 2005, 77, 6954 – 6959.en_US
dc.identifier.citedreferenceMorelle, W., Slomianny, M. C., Diemer, H., Schaeffer, C., van Dorsselaer, A., Michalski, J. C., Rapid Commun. Mass Spectrom. 2005, 19, 2075 – 2084.en_US
dc.identifier.citedreferenceChen, X. Y., Flynn, G. C., J. Am. Soc. Mass. Spectrom. 2009, 20, 1821 – 1833.en_US
dc.identifier.citedreferenceTakegawa, Y., Deguchi, K., Ito, S., Yoshioka, S., Nakagawa, H., Nishimura, S. I., Rapid Commun. Mass Spectrom. 2005, 19, 937 – 946.en_US
dc.identifier.citedreferenceDeguchi, K., Takegawa, Y., Ito, H., Miura, N., Yoshioka, S., Nagai, S., Nakagawa, H., Nishimura, S. I., Rapid Commun. Mass Spectrom. 2006, 20, 412 – 418.en_US
dc.identifier.citedreferenceBriggs, J. B., Keck, R. G., Ma, S., Lau, W. D., Jones, A. J. S., Anal. Biochem. 2009, 389, 40 – 51.en_US
dc.identifier.citedreferenceKuster, B., Naven, T. J. P., Harvey, D. J., Rapid Commun. Mass Spectrom. 1996, 10, 1645 – 1651.en_US
dc.identifier.citedreferenceWilson, J. J., Brodbelt, J. S., Anal. Chem. 2008, 80, 5186 – 5196.en_US
dc.identifier.citedreferenceMorelle, W., Page, A., Michalski, J. C., Rapid Commun. Mass Spectrom. 2005, 19, 1145 – 1158.en_US
dc.identifier.citedreferenceYang, J., Mo, J. J., Adamson, J. T., Håkansson, K., Anal. Chem. 2005, 77, 1876 – 1882.en_US
dc.identifier.citedreferenceTsybin, Y. O., Witt, M., Baykut, G., Kjeldsen, F., Hakansson, P., Rapid Commun. Mass Spectrom. 2003, 17, 1759 – 1768.en_US
dc.identifier.citedreferenceCaravatti, P., Allemann, M., Org. Mass Spectrom. 1991, 26, 514 – 518.en_US
dc.identifier.citedreferenceYang, J., Håkansson, K., Int. J. Mass Spectrom. 2008, 276, 144 – 148.en_US
dc.identifier.citedreferenceSenko, M. W., Canterbury, J. D., Guan, S. H., Marshall, A. G., Rapid Commun. Mass Spectrom. 1996, 10, 1839 – 1844.en_US
dc.identifier.citedreferenceLedford, E. B., Rempel, D. L., Gross, M. L., Anal. Chem. 1984, 56, 2744 – 2748.en_US
dc.identifier.citedreferenceLohmann, K. K., von der Lieth, C. W., Nucleic Acids Res. 2004, 32, W261 – W266.en_US
dc.identifier.citedreferenceDomon, B., Costello, C. E., Glycoconj. J. 1988, 5, 397 – 409.en_US
dc.identifier.citedreferenceHarvey, D. J., J. Am. Soc. Mass Spectrom. 2005, 16, 622 – 630.en_US
dc.identifier.citedreferenceHarvey, D. J., J. Am. Soc. Mass Spectrom. 2005, 16, 631 – 646.en_US
dc.identifier.citedreferenceHarvey, D. J., J. Am. Soc. Mass Spectrom. 2005, 16, 647 – 659.en_US
dc.identifier.citedreferencePikulski, M., Hargrove, A., Shabbir, S. H., Anslyn, E. V., Brodbelt, J. S., J. Am. Soc. Mass Spectrom. 2007, 18, 2094 – 2106.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
elps_201100327_sm_SupplInfo.pdf
Size:
87.06KB
Format:
PDF
View/Open
Name:
3526_ftp.pdf
Size:
360.9KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.