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Shadow enhancers: Frequently asked questions about distributed cis ‐regulatory information and enhancer redundancy
dc.contributor.authorBarolo, Scotten_US
dc.date.accessioned2012-03-16T15:55:31Z
dc.date.available2013-04-01T14:17:25Zen_US
dc.date.issued2012-02en_US
dc.identifier.citationBarolo, Scott (2012). "Shadow enhancers: Frequently asked questions about distributed cis ‐regulatory information and enhancer redundancy." BioEssays 34(2): 135-141. <http://hdl.handle.net/2027.42/90151>en_US
dc.identifier.issn0265-9247en_US
dc.identifier.issn1521-1878en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/90151
dc.description.abstractThis paper, in the form of a frequently asked questions page (FAQ), addresses outstanding questions about “shadow enhancers”, quasi‐redundant cis ‐regulatory elements, and their proposed roles in transcriptional control. Questions include: What exactly are shadow enhancers? How many genes have shadow/redundant/distributed enhancers? How redundant are these elements? What is the function of distributed enhancers? How modular are enhancers? Is it useful to study a single enhancer in isolation? In addition, a revised definition of “shadow enhancers” is proposed, and possible mechanisms of shadow enhancer function and evolution are discussed. The term “shadow enhancer” was coined rather recently and this article not only gives a revised definition of this term but also discusses possible mechanisms of shadow enhancer function and evolution.en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.subject.otherGenomicsen_US
dc.subject.otherTranscriptional Regulationen_US
dc.subject.otherCis ‐Regulatory Elementsen_US
dc.subject.otherEnhancersen_US
dc.subject.otherEvolutionen_US
dc.titleShadow enhancers: Frequently asked questions about distributed cis ‐regulatory information and enhancer redundancyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USAen_US
dc.identifier.pmid22083793en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/90151/1/135_ftp.pdf
dc.identifier.doi10.1002/bies.201100121en_US
dc.identifier.sourceBioEssaysen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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