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Synthesis of iodine‐125 labelled analogues of metyrapone and metyrapol
dc.contributor.authorHays, Sheryl J.en_US
dc.contributor.authorMangner, Thomas J.en_US
dc.date.accessioned2012-03-16T15:58:27Z
dc.date.available2012-03-16T15:58:27Z
dc.date.issued1983-12en_US
dc.identifier.citationHays, Sheryl J.; Mangner, Thomas J. (1983). "Synthesis of iodine‐125 labelled analogues of metyrapone and metyrapol." Journal of Labelled Compounds and Radiopharmaceuticals 20(12): 1373-1381. <http://hdl.handle.net/2027.42/90279>en_US
dc.identifier.issn0362-4803en_US
dc.identifier.issn1099-1344en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/90279
dc.description.abstractMetyrapone (1) and metyrapol (2) are potent and reversible inhibitors of the 11β‐hydroxylase enzyme system of the adrenal cortex. Iodine‐125‐labelled derivatives of 1 and 2 were required for biodistribution studies. Utilizing a new exchange procedure these radioiodinated analogues were synthesized with radiochemical yields ranging from 24‐100% and specific activities as high as 1.72 Ci/mmol.en_US
dc.publisherJohn Wiley & Sons, Ltd.en_US
dc.subject.other11β‐Hydroxylaseen_US
dc.subject.otherMetyraponeen_US
dc.subject.otherIodine‐125en_US
dc.subject.otherMetyrapolen_US
dc.titleSynthesis of iodine‐125 labelled analogues of metyrapone and metyrapolen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelRadiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Nuclear Medicine University of Michigan Medical Center Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationotherWarner Lambert/Parke Davis Pharmaceutical Division, 2800 Plymouth Rd., Ann Arbor, MI. 48105en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/90279/1/2580201209_ftp.pdf
dc.identifier.doi10.1002/jlcr.2580201209en_US
dc.identifier.sourceJournal of Labelled Compounds and Radiopharmaceuticalsen_US
dc.identifier.citedreferenceFieser L. F. and Fieser M. ‐ Reagents for Organic Synthesis 1: 153, John Wiley and Sons, Inc. New York ( 1967 )en_US
dc.identifier.citedreferenceLiddle G. W., Island D., Lance E. M. and Harris A. P. ‐ J. Clin. Endocrinol. Metab. 18: 906 ( 1958 )en_US
dc.identifier.citedreferenceStill W. C., Kahn M. and Mitra A. ‐ J. Org. Chem. 42: 2923 ( 1978 )en_US
dc.identifier.citedreferenceMangner T. J., Wu J. and Wieland D. M. ‐ J. Org. Chem. 47: 1484 ( 1982 )en_US
dc.identifier.citedreferenceNMR of 3‐iodobenzoic acid from The Aldrich Library of NMR Spectra.(C. J. Pouchert and J. R. Campbell, ed.) 6, 147A.en_US
dc.identifier.citedreferenceNMR of 2,5‐diiodobenzoic acids from The Sadtler Standard Spectra. Sadtler Research Laboratories. Philadelphia, Pa. 4630M.en_US
dc.identifier.citedreferenceBarker I. R. L. and Waters W. A. ‐ J. Chem. Soc. 150 ( 1952 )en_US
dc.identifier.citedreferenceDerbyshire D. H. and Waters W. A. ‐ J. Chem. Soc. 3694 ( 1950 )en_US
dc.identifier.citedreferenceHays S. J., Tobes M. C., Gildersleeve D. L., Wieland D. M. and Beierwaltes W. H. ‐ J. Med. Chem. Accepted for publication.en_US
dc.identifier.citedreferenceHays S. J., Tobes M. C., Brown L. E., Gildersleeve D. L., Marsh D. D., Wieland D. M. and Beierwaltes W. H. ‐ J. Nuclear Med. 23: P46 ( 1982 )en_US
dc.identifier.citedreferenceSatre M. and Vignais P. V. ‐ Biochemistry 13: 2201 ( 1974 )en_US
dc.identifier.citedreferenceDominguez O. V. and Samuels L. T. ‐ Endocrinology 73: 304 ( 1963 )en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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