Reduced insular γ‐aminobutyric acid in fibromyalgia
dc.contributor.author | Foerster, Bradley R. | en_US |
dc.contributor.author | Petrou, Myria | en_US |
dc.contributor.author | Edden, Richard A. E. | en_US |
dc.contributor.author | Sundgren, Pia C. | en_US |
dc.contributor.author | Schmidt‐wilcke, Tobias | en_US |
dc.contributor.author | Lowe, Suzan E. | en_US |
dc.contributor.author | Harte, Steven E. | en_US |
dc.contributor.author | Clauw, Daniel J. | en_US |
dc.contributor.author | Harris, Richard E. | en_US |
dc.date.accessioned | 2012-03-16T15:58:42Z | |
dc.date.available | 2013-04-01T14:17:24Z | en_US |
dc.date.issued | 2012-02 | en_US |
dc.identifier.citation | Foerster, Bradley R.; Petrou, Myria; Edden, Richard A. E.; Sundgren, Pia C.; Schmidt‐wilcke, Tobias ; Lowe, Suzan E.; Harte, Steven E.; Clauw, Daniel J.; Harris, Richard E. (2012). "Reduced insular γâ aminobutyric acid in fibromyalgia." Arthritis & Rheumatism 64(2): 579-583. <http://hdl.handle.net/2027.42/90292> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/90292 | |
dc.description.abstract | Objective Recent scientific findings have reinvigorated interest in examining the role of γ‐aminobutyric acid (GABA), the major inhibitory central nervous system neurotransmitter, in chronic pain conditions. Decreased inhibitory neurotransmission is a proposed mechanism in the pathophysiology of chronic pain syndromes such as fibromyalgia (FM). The purpose of this study was to test the hypothesis that decreased levels of insular and anterior cingulate GABA would be present in FM patients, and that the concentration of this neurotransmitter would be correlated with pressure–pain thresholds. Methods Sixteen FM patients and 17 age‐ and sex‐matched healthy controls underwent pressure–pain testing and a 3T proton magnetic resonance spectroscopy session in which the right anterior insula, right posterior insula, anterior cingulate, and occipital cortex were examined in subjects at rest. Results GABA levels in the right anterior insula were significantly lower in FM patients compared with healthy controls (mean ± SD 1.17 ± 0.24 arbitrary institutional units versus 1.42 ± 0.32 arbitrary institutional units; P = 0.016). There was a trend toward increased GABA levels in the anterior cingulate of FM patients compared with healthy controls ( P = 0.06). No significant differences between groups were detected in the posterior insula or occipital cortex ( P > 0.05 for all comparisons). Within the right posterior insula, higher levels of GABA were positively correlated with pressure–pain thresholds in the FM patients (Spearman's rho = 0.63; P = 0.02). Conclusion Diminished inhibitory neurotransmission resulting from lower concentrations of GABA within the right anterior insula may play a role in the pathophysiology of FM and other central pain syndromes. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.title | Reduced insular γ‐aminobutyric acid in fibromyalgia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan and Ann Arbor VA Healthcare System, Ann Arbor, Michigan, and Johns Hopkins University, Baltimore, Maryland | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, and Johns Hopkins University, Baltimore, Maryland | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, 1500 East Medical Center Drive UH B2 A205A, Ann Arbor, MI 48109‐5030 | en_US |
dc.contributor.affiliationother | Lund University, Lund, Sweden | en_US |
dc.contributor.affiliationother | Johns Hopkins University and Kennedy Krieger Institute, Baltimore, Maryland | en_US |
dc.identifier.pmid | 21913179 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/90292/1/33339_ftp.pdf | |
dc.identifier.doi | 10.1002/art.33339 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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