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On a heuristic point of view concerning the expression of numerous genes during the cell cycle

dc.contributor.authorCooper, Stephenen_US
dc.date.accessioned2012-03-16T16:00:46Z
dc.date.available2013-03-04T15:29:55Zen_US
dc.date.issued2012-01en_US
dc.identifier.citationCooper, Stephen (2012). "On a heuristic point of view concerning the expression of numerous genes during the cell cycle." IUBMB Life 64(1): 10-17. <http://hdl.handle.net/2027.42/90359>en_US
dc.identifier.issn1521-6543en_US
dc.identifier.issn1521-6551en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/90359
dc.description.abstractThe current model of the eukaryotic cell cycle proposes that numerous genes are expressed at different times during the cell cycle. The existence of myriad control points for gene expression leads to theoretical and logical problems for cell cycle control. Each expressed gene requires a control element to appear in a cell‐cycle specific manner; this control element requires another control element and so on, ad infinitum . There are also experimental problems with the current model based on ineffective synchronization methods and problems with microarray measurements of mRNA. Equally important, the efficacy of mRNA variation in affecting changes in protein content is negligible. An alternative view of the cell cycle proposes cycle‐independent, invariant accumulation of mRNA during the cell cycle with decreases of specific proteins occurring only during the mitotic period of the cell cycle. © 2011 IUBMB IUBMB Life, 2011.en_US
dc.publisherWiley Subscription Services, Inc., a Wiley companyen_US
dc.subject.otherCycle‐Specificen_US
dc.subject.otherGene Expressionen_US
dc.subject.otherCell Cycleen_US
dc.subject.otherMicroarraysen_US
dc.subject.otherCyclinsen_US
dc.subject.otherG1 Phaseen_US
dc.subject.otherSynchronizationen_US
dc.titleOn a heuristic point of view concerning the expression of numerous genes during the cell cycleen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109‐0520en_US
dc.contributor.affiliationumDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MIen_US
dc.identifier.pmid22095856en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/90359/1/571_ftp.pdf
dc.identifier.doi10.1002/iub.571en_US
dc.identifier.sourceIUBMB Lifeen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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