Revisiting the Response Mechanism of Polymeric Membrane Based Heparin Electrodes
dc.contributor.author | Bell, Andrea K. | en_US |
dc.contributor.author | Höfler, Lajos | en_US |
dc.contributor.author | Meyerhoff, Mark E. | en_US |
dc.date.accessioned | 2012-03-16T16:01:45Z | |
dc.date.available | 2013-03-04T15:29:56Z | en_US |
dc.date.issued | 2012-01 | en_US |
dc.identifier.citation | Bell, Andrea K.; Höfler, Lajos ; Meyerhoff, Mark E. (2012). "Revisiting the Response Mechanism of Polymeric Membrane Based Heparin Electrodes." Electroanalysis 24(1): 53-59. <http://hdl.handle.net/2027.42/90404> | en_US |
dc.identifier.issn | 1040-0397 | en_US |
dc.identifier.issn | 1521-4109 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/90404 | |
dc.description.abstract | Potentiometric membrane electrodes that respond to heparin and other polyanions were introduced in the early 1990s. Herein, the mechanism of polymer membrane electrode type heparin sensors is revisited. The extraction/diffusion of heparin is studied via both potentiometric and impedance spectroscopic techniques using a prefractionated heparin preparation that contains polyanionic species >10 000 Daltons. The reversal in EMF response using this heparin preparation indicates diffusion of higher MW heparin fragments to the backside of the membrane. Diffusion coefficients are calculated using a novel formula derived from the phase boundary potential model and Fick′s second law of diffusion. Impedance spectroscopy is also employed to show that high MW heparin species are extracted and diffuse across the PVC membranes. | en_US |
dc.publisher | WILEY‐VCH Verlag | en_US |
dc.subject.other | Heparin | en_US |
dc.subject.other | Diffusion Coefficients | en_US |
dc.subject.other | Ion‐Selective Membrane | en_US |
dc.subject.other | Transport Mechanism | en_US |
dc.title | Revisiting the Response Mechanism of Polymeric Membrane Based Heparin Electrodes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109‐1055, USA | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109‐1055, USA | en_US |
dc.identifier.pmid | 23293506 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/90404/1/53_ftp.pdf | |
dc.identifier.doi | 10.1002/elan.201100423 | en_US |
dc.identifier.source | Electroanalysis | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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