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Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12–19‐year cohort study
dc.contributor.authorRao, Hui‐Yingen_US
dc.contributor.authorSun, De‐Guien_US
dc.contributor.authorYang, Rui‐Fengen_US
dc.contributor.authorLiu, Fengen_US
dc.contributor.authorWang, Jianen_US
dc.contributor.authorFeng, Boen_US
dc.contributor.authorWu, Nanen_US
dc.contributor.authorFang, Ji-Lianen_US
dc.contributor.authorSong, Guang‐Junen_US
dc.contributor.authorMa, Huien_US
dc.contributor.authorGuo, Fangen_US
dc.contributor.authorWang, Jiang‐Huaen_US
dc.contributor.authorLi, Xiao‐Boen_US
dc.contributor.authorJin, Qianen_US
dc.contributor.authorQin, Hongen_US
dc.contributor.authorZhuang, Huien_US
dc.contributor.authorWei, Laien_US
dc.date.accessioned2012-03-16T16:02:05Z
dc.date.available2013-05-01T17:24:43Zen_US
dc.date.issued2012-03en_US
dc.identifier.citationRao, Hui‐ying ; Sun, De‐gui ; Yang, Rui‐feng ; Liu, Feng; Wang, Jian; Feng, Bo; Wu, Nan; Fang, Ji‐lian ; Song, Guang‐jun ; Ma, Hui; Guo, Fang; Wang, Jiang‐hua ; Li, Xiao‐bo ; Jin, Qian; Qin, Hong; Zhuang, Hui; Wei, Lai (2012). "Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12â 19â year cohort study." Journal of Gastroenterology and Hepatology 27(3). <http://hdl.handle.net/2027.42/90418>en_US
dc.identifier.issn0815-9319en_US
dc.identifier.issn1440-1746en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/90418
dc.description.abstractBackground and Aims:  Commercial plasma donation was introduced in China in the 1970s. Cases of non‐A, non‐B hepatitis (hepatitis C) continued to occur, with multiple outbreaks among plasma donors in Guan county, Hebei province between 1972 and 1990. The outcomes of hepatitis C virus (HCV) infection in these paid plasma donors from six villages of Guan county were followed up for 12–19 years. Methods:  A total of 402 plasma donors with HCV infection were enrolled since anti‐HCV‐positive in 1991 or 1998. Follow up was maintained until death or the end of the observation period. No antiviral treatment was applied during the period of infection. Results:  Follow up was lost in 23 cases. After a 12–19‐year follow up, 31 donors died, with the cause of death directly related to liver disease in 15 cases, and an overall mortality of 8.18% (31/379). The incidence of liver cirrhosis was 10.03%, and hepatocellular carcinoma (HCC) was 2.90%. The rate of viral spontaneous clearing was 20.32% (77/379), and 13.69% (23/168) in males and 25.59% (54/211) in females. In May 2010, detections were performed in 348 cases. Abnormality of liver function was related to HCV viremia. Sex and alcohol intake impacted the outcome of HCV infection. There was no correlation between the viral spontaneous clearance with age of infection and genotype. Conclusions:  This area has a high rate of chronicity in HCV infection due to plasma donation. Twenty‐five years after virus infection, liver cirrhosis or HCC developed in one‐tenth of patients, with an overall mortality of 8.18%.en_US
dc.publisherBlackwell Publishing Asiaen_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherPlasma Donoren_US
dc.subject.otherHepatitis C Virusen_US
dc.subject.otherOutcomeen_US
dc.titleOutcome of hepatitis C virus infection in Chinese paid plasma donors: A 12–19‐year cohort studyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumPeking University Health Science Center–University of Michigan Health System, Joint Institute for Translational and Clinical Research, Beijing, Chinaen_US
dc.contributor.affiliationotherDepartment of Microbiology, Peking University Health Science Center, Beijing, Chinaen_US
dc.contributor.affiliationotherGuan County Center for Disease Control and Prevention, Hebei Guan, Chinaen_US
dc.contributor.affiliationotherPeking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing, Chinaen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/90418/1/j.1440-1746.2011.06880.x.pdf
dc.identifier.doi10.1111/j.1440-1746.2011.06880.xen_US
dc.identifier.sourceJournal of Gastroenterology and Hepatologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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