Differential Dependence on Cysteine from Transsulfuration versus Transport During T Cell Activation
dc.contributor.author | Garg, Sanjay K. | en_US |
dc.contributor.author | Yan, Zhonghua | en_US |
dc.contributor.author | Vitvitsky, Victor M. | en_US |
dc.contributor.author | Banerjee, Ruma | en_US |
dc.date.accessioned | 2012-03-22T17:23:43Z | |
dc.date.available | 2012-03-22T17:23:43Z | |
dc.date.issued | 2011-07-01 | en_US |
dc.identifier.citation | Garg, Sanjay K.; Yan, Zhonghua; Vitvitsky, Victor; Banerjee, Ruma (2011). "Differential Dependence on Cysteine from Transsulfuration versus Transport During T Cell Activation." Antioxidants & Redox Signaling, 15(1): 39-47. <http://hdl.handle.net/2027.42/90472> | en_US |
dc.identifier.issn | 1523-0864 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/90472 | |
dc.description.abstract | The synthesis of glutathione, a major cellular antioxidant with a critical role in T cell proliferation, is limited by cysteine. In this study, we evaluated the contributions of the xC- cystine transporter and the transsulfuration pathway to cysteine provision for glutathione synthesis and antioxidant defense in naive versus activated T cells and in the immortalized T lymphocyte cell line, Jurkat. We show that the xC- transporter, although absent in naive T cells, is induced after activation, releasing T cells from their cysteine dependence on antigen-presenting cells. We also demonstrate the existence of an intact transsulfuration pathway in naive and activated T cells and in Jurkat cells. The flux through the transsulfuration pathway increases in primary but not in transformed T cells in response to oxidative challenge by peroxide. Inhibition of the transsulfuration pathway in both primary and transformed T cells decreases cell viability under oxidative-stress conditions. Antioxid. Redox Signal. 15, 39-47. | en_US |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | Differential Dependence on Cysteine from Transsulfuration versus Transport During T Cell Activation | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 20673163 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/90472/1/ars-2E2010-2E3496.pdf | |
dc.identifier.doi | 10.1089/ars.2010.3496 | en_US |
dc.identifier.source | Antioxidants & Redox Signaling | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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