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Using polymeric materials to control stem cell behavior for tissue regeneration
dc.contributor.authorZhang, Nianlien_US
dc.contributor.authorKohn, David H.en_US
dc.date.accessioned2012-04-04T18:43:42Z
dc.date.available2013-05-01T17:24:43Zen_US
dc.date.issued2012-03en_US
dc.identifier.citationZhang, Nianli; Kohn, David H. (2012). "Using polymeric materials to control stem cell behavior for tissue regeneration." Birth Defects Research Part C: Embryo Today: Reviews 96(1): 63-81. <http://hdl.handle.net/2027.42/90582>en_US
dc.identifier.issn1542-975Xen_US
dc.identifier.issn1542-9768en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/90582
dc.description.abstractPatients with organ failure often suffer from increased morbidity and decreased quality of life. Current strategies of treating organ failure have limitations, including shortage of donor organs, low efficiency of grafts, and immunological problems. Tissue engineering emerged about two decades ago as a strategy to restore organ function with a living, functional engineered substitute. However, the ability to engineer a functional organ is limited by a limited understanding of the interactions between materials and cells that are required to yield functional tissue equivalents. Polymeric materials are one of the most promising classes of materials for use in tissue engineering, due to their biodegradability, flexibility in processing and property design, and the potential to use polymer properties to control cell function. Stem cells offer potential in tissue engineering because of their unique capacity to self‐renew and differentiate into neurogenic, osteogenic, chondrogenic, and myogenic lineages under appropriate stimuli from extracellular components. This review examines recent advances in stem cell–polymer interactions for tissue regeneration, specifically highlighting control of polymer properties to direct adhesion, proliferation, and differentiation of stem cells, and how biomaterials can be designed to provide some of the stimuli to cells that the natural extracellular matrix does. (Part C) 96:63–81, 2012. © 2012 Wiley Periodicals, Inc.en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherDifferentiationen_US
dc.subject.otherPolymeren_US
dc.subject.otherTissue Engineeringen_US
dc.subject.otherAdhesionen_US
dc.subject.otherProliferationen_US
dc.subject.otherStem Cellsen_US
dc.titleUsing polymeric materials to control stem cell behavior for tissue regenerationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelObstetrics and Gynecologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109‐2099en_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109‐1078en_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109‐1078en_US
dc.identifier.pmid22457178en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/90582/1/21003_ftp.pdf
dc.identifier.doi10.1002/bdrc.21003en_US
dc.identifier.sourceBirth Defects Research Part C: Embryo Today: Reviewsen_US
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