Implementation of the Exception From Informed Consent Regulations in a Large Multicenter Emergency Clinical Trials Network: The RAMPART Experience
dc.contributor.author | Silbergleit, Robert | en_US |
dc.contributor.author | Biros, Michelle H. | en_US |
dc.contributor.author | Harney, Deneil | en_US |
dc.contributor.author | Dickert, Neal | en_US |
dc.contributor.author | Baren, Jill | en_US |
dc.date.accessioned | 2012-05-21T15:47:49Z | |
dc.date.available | 2013-06-11T19:15:51Z | en_US |
dc.date.issued | 2012-04 | en_US |
dc.identifier.citation | Silbergleit, Robert; Biros, Michelle H.; Harney, Deneil; Dickert, Neal; Baren, Jill (2012). "Implementation of the Exception From Informed Consent Regulations in a Large Multicenter Emergency Clinical Trials Network: The RAMPART Experience." Academic Emergency Medicine 19(4). <http://hdl.handle.net/2027.42/91139> | en_US |
dc.identifier.issn | 1069-6563 | en_US |
dc.identifier.issn | 1553-2712 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/91139 | |
dc.description.abstract | Clinical trials investigating therapies for acutely and critically ill and injured patients in the earliest phases of treatment often can only be performed under regulations allowing for exception from informed consent (EFIC) for emergency research. Implementation of these regulations in multicenter clinical trials involves special challenges and opportunities. The Rapid Anticonvulsant Medication Prior to Arrival Trial (RAMPART), the first EFIC trial conducted by the Neurological Emergencies Treatment Trials (NETT) network, combined centralized resources and coordination with retention of local control and flexibility to facilitate compliance with the EFIC regulations. Specific methods used by the NETT included common tools for community consultation and public disclosure, sharing of experiences and knowledge, and reporting of aggregate results. Tracking of community consultation and public disclosure activities and feedback facilitates empirical research on EFIC methods in the network and supports quality improvements for future NETT trials. The NETT model used in RAMPART demonstrates how EFIC may be effectively performed in established clinical trial networks. | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.title | Implementation of the Exception From Informed Consent Regulations in a Large Multicenter Emergency Clinical Trials Network: The RAMPART Experience | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | From the Department of Emergency Medicine, University of Michigan (RS, DH), Ann Arbor, MI; the Department of Emergency Medicine, University of Minnesota (MHB), Minneapolis, MN; the Division of Cardiology, Emory University (ND), Atlanta, GA; and the Department of Emergency Medicine, University of Pennsylvania (JB), Philadelphia, PA. *See appendix for a list of the NETT Investigators. | en_US |
dc.identifier.pmid | 22506949 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/91139/1/j.1553-2712.2012.01328.x.pdf | |
dc.identifier.doi | 10.1111/j.1553-2712.2012.01328.x | en_US |
dc.identifier.source | Academic Emergency Medicine | en_US |
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dc.identifier.citedreference | Mosesso VN Jr, Brown LH, Greene HL, et al. Conducting research using the emergency exception from informed consent: the Public Access Defibrillation (PAD) Trial experience. Resuscitation. 2004; 61: 29 – 36. | en_US |
dc.identifier.citedreference | Ripley E. Community Partnership for Ethical Research. NIH Reporter. Available at: http://projectreporter.nih.gov/project_info_description.cfm?aid=7935323&icde=10082134. Accessed Jan 15, 2012. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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