CD24 on thymic APCs regulates negative selection of myelin antigen‐specific T lymphocytes
dc.contributor.author | Zhang, Xuejun | en_US |
dc.contributor.author | Liu, Jin‐qing | en_US |
dc.contributor.author | Shi, Yun | en_US |
dc.contributor.author | Reid, Hugh H. | en_US |
dc.contributor.author | Boyd, Richard L. | en_US |
dc.contributor.author | Khattabi, Mazin | en_US |
dc.contributor.author | El‐omrani, Hani Y. | en_US |
dc.contributor.author | Zheng, Pan | en_US |
dc.contributor.author | Liu, Yang | en_US |
dc.contributor.author | Bai, Xue‐feng | en_US |
dc.date.accessioned | 2012-05-21T15:48:09Z | |
dc.date.available | 2013-06-11T19:15:51Z | en_US |
dc.date.issued | 2012-04 | en_US |
dc.identifier.citation | Zhang, Xuejun; Liu, Jin‐qing ; Shi, Yun; Reid, Hugh H.; Boyd, Richard L.; Khattabi, Mazin; El‐omrani, Hani Y. ; Zheng, Pan; Liu, Yang; Bai, Xue‐feng (2012). "CD24 on thymic APCs regulates negative selection of myelin antigenâ specific T lymphocytes." European Journal of Immunology 42(4): 924-935. <http://hdl.handle.net/2027.42/91152> | en_US |
dc.identifier.issn | 0014-2980 | en_US |
dc.identifier.issn | 1521-4141 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/91152 | |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Autoimmunity | en_US |
dc.subject.other | TCR | en_US |
dc.subject.other | CD4 + T Cell | en_US |
dc.subject.other | Thymic Selection | en_US |
dc.title | CD24 on thymic APCs regulates negative selection of myelin antigen‐specific T lymphocytes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 22213356 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/91152/1/eji1398.pdf | |
dc.identifier.doi | 10.1002/eji.201142024 | en_US |
dc.identifier.source | European Journal of Immunology | en_US |
dc.identifier.citedreference | Chen, G. Y., Tang, J., Zheng, P. and Liu, Y., CD24 and Siglec‐10 selectively repress tissue damage‐induced immune responses. Science 2009. 323: 1722 – 1725. | en_US |
dc.identifier.citedreference | Williams, L. A., McLellan, A. D., Summers, K. L., Sorg, R. V., Fearnley, D. B. and Hart, D. N., Identification of a novel dendritic cell surface antigen defined by carbohydrate specific CD24 antibody cross‐reactivity. Immunology 1996. 89: 120 – 125. | en_US |
dc.identifier.citedreference | Kay, R., Rosten, P. M. and Humphries, R. K., CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor. J. Immunol. 1991. 147: 1412 – 1416. | en_US |
dc.identifier.citedreference | Jung, K. C., Park, W. S., Kim, H. J., Choi, E. Y., Kook, M. C., Lee, H. W. and Bae, Y., TCR‐independent and caspase‐independent apoptosis of murine thymocytes by CD24 cross‐linking. J. Immunol. 2004. 172: 795 – 802. | en_US |
dc.identifier.citedreference | Hough, M. R., Takei, F., Humphries, R. K. and Kay, R., Defective development of thymocytes overexpressing the costimulatory molecule, heat‐stable antigen. J. Exp. Med. 1994. 179: 177 – 184. | en_US |
dc.identifier.citedreference | Zhou, Q., Wu, Y., Nielsen, P. J. and Liu, Y., Homotypic interaction of the heat‐stable antigen is not responsible for its co‐stimulatory activity for T‐cell clonal expansion. Eur. J. Immunol. 1997. 27: 2524 – 2528. | en_US |
dc.identifier.citedreference | Carl, J. W., Jr., Liu, J. Q., Joshi, P. S., El‐Omrani, H. Y., Yin, L., Zheng, X., Whitacre, C. C. et al., Autoreactive T cells escape clonal deletion in the thymus by a CD24‐dependent pathway. J. Immunol. 2008. 181: 320 – 328. | en_US |
dc.identifier.citedreference | Linares, D., Mana, P., Goodyear, M., Chow, A. M., Clavarino, C., Huntington, N. D., Barnett, L. et al., The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice. J. Autoimmun. 2003. 21: 339 – 351. | en_US |
dc.identifier.citedreference | Tarakhovsky, A., Kanner, S. B., Hombach, J., Ledbetter, J. A., Muller, W., Killeen, N. and Rajewsky, K., A role for CD5 in TCR‐mediated signal transduction and thymocyte selection. Science 1995. 269: 535 – 537. | en_US |
dc.identifier.citedreference | Azzam, H. S., Grinberg, A., Lui, K., Shen, H., Shores, E. W. and Love, P. E., CD5 expression is developmentally regulated by T‐cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 1998. 188: 2301 – 2311. | en_US |
dc.identifier.citedreference | Delarasse, C., Daubas, P., Mars, L. T., Vizler, C., Litzenburger, T., Iglesias, A., Bauer, J. et al., Myelin/oligodendrocyte glycoprotein‐deficient (MOG‐deficient) mice reveal lack of immune tolerance to MOG in wild‐type mice. J. Clin. Invest. 2003. 112: 544 – 553. | en_US |
dc.identifier.citedreference | Fazilleau, N., Delarasse, C., Sweenie, C. H., Anderton, S. M., Fillatreau, S., Lemonnier, F. A., Pham‐Dinh, D. et al., Persistence ofautoreactive myelin oligodendrocyte glycoprotein (MOG)‐specific T‐cell repertoires in MOG‐expressing mice. Eur. J. Immunol. 2006. 36: 533 – 543. | en_US |
dc.identifier.citedreference | Fazilleau, N., Delarasse, C., Motta, I., Fillatreau, S., Gougeon, M. L., Kourilsky, P., Pham‐Dinh, D. et al., T‐cell repertoire diversity is required for relapses in myelin oligodendrocyte glycoprotein‐induced experimental autoimmune encephalomyelitis. J. Immunol. 2007. 178: 4865 – 4875. | en_US |
dc.identifier.citedreference | Krishnamoorthy, G., Saxena, A., Mars, L. T., Domingues, H. S., Mentele, R., Ben‐Nun, A., Lassmann, H. et al., Myelin‐specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat. Med. 2009. 15: 626 – 632. | en_US |
dc.identifier.citedreference | Marx, A., Wilisch, A., Schultz, A., Greiner, A., Magi, B., Pallini, V., Schalke, B. et al., Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis. Am. J. Pathol. 1996. 148: 1839 – 1850. | en_US |
dc.identifier.citedreference | Gallegos, A. M. and Bevan, M. J., Central tolerance to tissue‐specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 2004. 200: 1039 – 1049. | en_US |
dc.identifier.citedreference | Liu, Y., Chen, G. Y. and Zheng, P., CD24‐Siglec G/10 discriminates danger‐ from pathogen‐associated molecular patterns. Trends Immunol. 2009. 30: 557 – 561. | en_US |
dc.identifier.citedreference | Boon, T., Cerottini, J. C., Van den Eynde, B., van der Bruggen, P. and Van Pel, A., Tumor antigens recognized by T lymphocytes. Annu. Rev. Immunol. 1994. 12: 337 – 365. | en_US |
dc.identifier.citedreference | Bai, X. F., Li, O., Zhou, Q., Zhang, H., Joshi, P. S., Zheng, X., Liu, Y. et al., CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalo‐myelitis. J. Exp. Med. 2004. 200: 447 – 458. | en_US |
dc.identifier.citedreference | Zhou, Q., Rammohan, K., Lin, S., Robinson, N., Li, O., Liu, X., Bai, X. F. et al., CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proc. Natl. Acad. Sci. USA 2003. 100: 15041 – 15046. | en_US |
dc.identifier.citedreference | Wang, L., Lin, S., Rammohan, K. W., Liu, Z., Liu, J. Q., Liu, R. H., Guinther, N. et al., A dinucleotide deletion in CD24 confers protection against autoimmune diseases. PLoS Genet. 2007. 3: e49. | en_US |
dc.identifier.citedreference | Liu, Y. and Zheng, P., CD24: a genetic checkpoint in T‐cell homeostasis and autoimmune diseases. Trends Immunol. 2007. 28: 315 – 320. | en_US |
dc.identifier.citedreference | Sanchez, E., Fernandez‐Gutierrez, B., Gonzalez‐Gay, M. A., Balsa, A., Garcia, A., Rodriguez, L., Pascual‐Salcedo, D. et al., Investigating the role of CD24 gene polymorphisms in rheumatoid arthritis. Ann. Rheum. Dis. 2008. 67: 1197 – 1198. | en_US |
dc.identifier.citedreference | Bettelli, E., Pagany, M., Weiner, H. L., Linington, C., Sobel, R. A. and Kuchroo, V. K., Myelin oligodendrocyte glycoprotein‐specific T‐cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J. Exp. Med. 2003. 197: 1073 – 1081. | en_US |
dc.identifier.citedreference | Bai, X. F., Liu, J. Q., Liu, X., Guo, Y., Cox, K., Wen, J., Zheng, P. et al., The heat‐stable antigen determines pathogenicity of self‐reactive T cells in experimental autoimmune encephalomyelitis. J. Gin. Invest. 2000. 105: 1227 – 1232. | en_US |
dc.identifier.citedreference | Zhou, Q., Guo, Y. and Liu, Y., Regulation of the stability of heat‐stable antigen mRNA by interplay between two novel cis elements in the 3’ untranslated region. Mol. Cell. Biol. 1998. 18: 815 – 826. | en_US |
dc.identifier.citedreference | Brocker, T., Riedinger, M. and Karjalainen, K., Driving gene expression specifically in dendritic cells. Adv. Exp. Med. Biol. 1997. 417: 55 – 57. | en_US |
dc.identifier.citedreference | Chen, M., Wang, Y. H., Wang, Y., Huang, L., Sandoval, H., Liu, Y. J. and Wang, J., Dendritic cell apoptosis in the maintenance of immune tolerance. Science 2006. 311: 1160 – 1164. | en_US |
dc.identifier.citedreference | Sprent, J. and Kishimoto, H., The thymus and negative selection. Immunol. Rev. 2002. 185: 126 – 135. | en_US |
dc.identifier.citedreference | von Boehmer, H. and Kisielow, P., Negative selection of the T‐cell repertoire: where and when does it occur? Immunol. Rev. 2006. 209: 284 – 289. | en_US |
dc.identifier.citedreference | Hanahan, D., Peripheral‐antigen‐expressing cells in thymic medulla: Factors in self‐tolerance and autoimmunity. Curr. Opin. Immunol. 1998. 10: 656 – 662. | en_US |
dc.identifier.citedreference | Derbinski, J., Schulte, A., Kyewski, B., and Klein, L., Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2001. 2: 1032 – 1039. | en_US |
dc.identifier.citedreference | Liston, A., Lesage, S., Wilson, J., Peltonen, L. and Goodnow, C. C., Aire regulates negative selection of organ‐specific T cells. Nat. Immunol. 2003. 4: 350 – 354. | en_US |
dc.identifier.citedreference | Anderson, M. S., Venanzi, E. S., Klein, L., Chen, Z., Berzins, S. P., Turley, S. J., von Boehmer, H. et al., Projection of an immunological self shadow within the thymus by the aire protein. Science 2002. 298: 1395 – 1401. | en_US |
dc.identifier.citedreference | Anderson, M. S., Venanzi, E. S., Chen, Z., Berzins, S. P., Benoist, C. and Mathis, D., The cellular mechanism of Aire control of T‐cell tolerance. Immunity 2005. 23: 227 – 239. | en_US |
dc.identifier.citedreference | Throsby, M., Homo‐Delarche, F., Chevenne, D., Goya, R., Dardenne, M. and Pleau, J. M., Pancreatic hormone expression in the murine thymus: Localization in dendritic cells and macrophages. Endocrinology 1998. 139: 2399 – 2406. | en_US |
dc.identifier.citedreference | Pugliese, A., Brown, D., Garza, D., Murchison, D., Zeller, M., Redondo, M. J., Diez, J. et al., Self‐antigen‐presenting cells expressing diabetes‐associated autoantigens exist in both thymus and peripheral lymphoid organs. J. Clin. Invest. 2001. 107: 555 – 564. | en_US |
dc.identifier.citedreference | Rincon, M., Whitmarsh, A., Yang, D. D., Weiss, L., Derijard, B., Jayaraj, P., Davis, R. J. et al., The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes. J. Exp. Med. 1998. 188: 1817 – 1830. | en_US |
dc.identifier.citedreference | Sabapathy, K., Kallunki, T., David, J. P., Graef, I., Karin, M. and Wagner, E. F., c‐Jun NH2‐terminal kinase (JNK)1 and JNK2 have similar and stage‐dependent roles in regulating T‐cell apoptosis and proliferation. J. Exp. Med. 2001. 193: 317 – 328. | en_US |
dc.identifier.citedreference | Behrens, A., Sabapathy, K., Graef, I., Cleary, M., Crabtree, G. R. and Wagner, E. F., Jun N‐terminal kinase 2 modulates thymocyte apoptosis and T‐cell activation through c‐Jun and nuclear factor of activated T‐cell (NF‐AT). Proc. Natl. Acad. Sci. USA 2001. 98: 1769 – 1774. | en_US |
dc.identifier.citedreference | Finnish‐German APECED Consortium, An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD‐type zinc‐finger domains. Nat. Genet. 1997. 17: 399 – 403. | en_US |
dc.identifier.citedreference | Nagamine, K., Peterson, P., Scott, H. S., Kudoh, J., Minoshima, S., Heino, M., Krohn, K. J. et al., Positional cloning of the APECED gene. Nat. Genet. 1997. 17: 393 – 398. | en_US |
dc.identifier.citedreference | Sun, J. B., Olsson, T., Wang, W. Z., Xiao, B. G., Kostulas, V., Fredrikson, S., Ekre, H. P. et al., Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur. J. Immunol. 1991. 21: 1461 – 1468. | en_US |
dc.identifier.citedreference | Liblau, R., Tournier‐Lasserve, E., Maciazek, J., Dumas, G., Siffert, O., Hashim, G. and Bach, M. A., T‐cell response to myelin basic protein epitopes in multiple sclerosis patients and healthy subjects. Eur. J. Immunol. 1991. 21: 1391 – 1395. | en_US |
dc.identifier.citedreference | Ota, K., Matsui, M., Milford, E. L., Mackin, G. A., Weiner, H. L. and Hafler, D. A., T‐cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990. 346: 183 – 187. | en_US |
dc.identifier.citedreference | Kuchroo, V. K., Anderson, A. C., Waldner, H., Munder, M., Bettelli, E. and Nicholson, L. B., T‐cell response in experimental autoimmune encepha‐lomyelitis (EAE): role of self and cross‐reactive antigens in shaping, tuning, and regulating the autopathogenic T‐cell repertoire. Annu. Rev. Immunol. 2002. 20: 101 – 123. | en_US |
dc.identifier.citedreference | Klein, L., Klugmann, M., Nave, K. A., Tuohy, V. K. and Kyewski, B., Shaping of the autoreactive T‐cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 2000. 6: 56 – 61. | en_US |
dc.identifier.citedreference | Anderson, A. C., Nicholson, L. B., Legge, K. L., Turchin, V., Zaghouani, H. and Kuchroo, V. K., High frequency of autoreactive myelin proteolipid protein‐specific T cells in the periphery of naive mice: mechanisms of selection of the self‐reactive repertoire. J. Exp. Med. 2000. 191: 761 – 770. | en_US |
dc.identifier.citedreference | Sarma, S., Guo, Y., Guilloux, Y., Lee, C., Bai, X. F. and Liu, Y., Cytotoxic T lymphocytes to an unmutated tumor rejection antigen P1A: normal development but restrained effector function in vivo. J. Exp. Med. 1999. 189: 811 – 820. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.