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Bio‐Orthogonal Polymer Coatings for Co‐Presentation of Biomolecules

dc.contributor.authorDeng, Xiaopeien_US
dc.contributor.authorEyster, Thomas W.en_US
dc.contributor.authorElkasabi, Yaseenen_US
dc.contributor.authorLahann, Joergen_US
dc.date.accessioned2012-05-21T15:49:01Z
dc.date.available2013-06-11T19:15:53Zen_US
dc.date.issued2012-04-23en_US
dc.identifier.citationDeng, Xiaopei; Eyster, Thomas W.; Elkasabi, Yaseen; Lahann, Joerg (2012). "Bio‐Orthogonal Polymer Coatings for Co‐Presentation of Biomolecules." Macromolecular Rapid Communications 33(8): 640-645. <http://hdl.handle.net/2027.42/91189>en_US
dc.identifier.issn1022-1336en_US
dc.identifier.issn1521-3927en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/91189
dc.description.abstractControlled presentation of biomolecules on synthetic substrates is an important aspect for biomaterials development. If the immobilization of multiple biomolecules is required, highly efficient orthogonal surface chemistries are needed to ensure the precision of the immobilization. In this communication, chemical vapor deposition (CVD) copolymerization is used to fabricate polymer coatings with controlled ratio of alkyne and pentafluorophenyl ester (Pfp‐ester) groups. Cyclic argine‐glycine‐aspartic acid (cRGD) adhesion peptide and epidermal growth factor (EGF) are immobilized through alkyne–azide cycloaddtion (“click” chemistry) and active ester–amine reaction, respectively. Cell studies with human umbilical vein endothelial cells (HUVEC) and A431 cell lines demonstrate the biological activity of the coimmobilized biomolecules. Polymer coatings with bio‐orthogonal functional groups are developed for co‐immobilization of adhesion peptide and growth factor. The coatings are generated by chemical vapor deposition polymerization, with both alkyne and pentafluorophenyl ester which are used to covalently tether the biomolecules. The biological activity of the co‐immobilized biomolecules is demonstrated.en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.subject.otherSurface Engineeringen_US
dc.subject.otherImmobilizationen_US
dc.subject.otherCoatingsen_US
dc.subject.otherBiomoleculesen_US
dc.subject.otherBiomaterialsen_US
dc.titleBio‐Orthogonal Polymer Coatings for Co‐Presentation of Biomoleculesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMaterials Science and Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMacromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumChemical Engineering, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumChemical Engineering, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartments of Chemical Engineering, Materials Science and Engineering, Macromolecular Science and Engineering and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann‐von‐ Helmholtz‐Platz 1, 76344 Eggenstein‐Leopoldshafen, Germanyen_US
dc.contributor.affiliationumDepartments of Chemical Engineering, Materials Science and Engineering, Macromolecular Science and Engineering and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann‐von‐ Helmholtz‐Platz 1, 76344 Eggenstein‐Leopoldshafen, Germany.en_US
dc.identifier.pmid22351186en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/91189/1/marc_201100819_sm_suppl.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/91189/2/640_ftp.pdf
dc.identifier.doi10.1002/marc.201100819en_US
dc.identifier.sourceMacromolecular Rapid Communicationsen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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