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Time course of tinnitus development following noise exposure in mice
dc.contributor.authorTurner, Jeremyen_US
dc.contributor.authorLarsen, Deben_US
dc.contributor.authorHughes, Larryen_US
dc.contributor.authorMoechars, Diederiken_US
dc.contributor.authorShore, Susanen_US
dc.date.accessioned2012-06-15T14:33:39Z
dc.date.available2013-09-03T15:38:26Zen_US
dc.date.issued2012-07en_US
dc.identifier.citationTurner, Jeremy; Larsen, Deb; Hughes, Larry; Moechars, Diederik; Shore, Susan (2012). "Time course of tinnitus development following noise exposure in mice." Journal of Neuroscience Research 90(7): 1480-1488. <http://hdl.handle.net/2027.42/91367>en_US
dc.identifier.issn0360-4012en_US
dc.identifier.issn1097-4547en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/91367
dc.description.abstractGap‐induced prepulse inhibition of acoustic startle (GPIAS) has been used in rats and mice to study the problem of tinnitus. The current study demonstrates that similar methods can be used to study the temporal development of tinnitus over time in middle‐aged mice. Six‐month‐old mice on a mixed C57Bl6 × 129 background were anesthetized with isoflurane and exposed to unilateral noise (n = 15), or sham exposure for controls (n = 8), for 1 hr (16‐kHz octave band signal, 116‐dB SPL). Tinnitus was tested in eight different sound frequency bands before and at postexposure time points of 1, 3–4, 7, 14, 21, and 30 days and monthly thereafter until 7 months postexposure. Noise‐exposed mice displayed a number of changes in GPIAS consistent with the presence of hyperacusis and tinnitus. Noise exposure was associated with acute tinnitus measured 1 day later at several frequencies at and above the exposure frequency center. Consistent, chronic tinnitus then emerged in the 24‐kHz range. Several time points following noise exposure suggested evidence of hyperacusis, often followed temporally by the development of deficits in GPIAS (reflecting tinnitus). Temporal development of these changes following noise exposure are discussed in the context of the interactions among aging, noise exposure, and the associated neurochemical changes that occur at early stages of auditory processing. © 2012 Wiley Periodicals, Inc.en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherCochlear Damageen_US
dc.subject.otherGapen_US
dc.subject.otherTinnitusen_US
dc.subject.otherHearingen_US
dc.subject.otherMouseen_US
dc.titleTime course of tinnitus development following noise exposure in miceen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKresge Hearing Research Institute, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumMolecular and Integrative Physiology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherJohnson and Johnson Pharmaceutical Research and Development, Beerse, Belgiumen_US
dc.contributor.affiliationotherDepartment of Psychology, Illinois College, Jacksonville, Illinoisen_US
dc.contributor.affiliationotherDepartment of Surgery/Otolaryngology, Southern Illinois University School of Medicine, Springfield, Illinoisen_US
dc.contributor.affiliationotherDepartment of Surgery/Otolaryngology, Southern Illinois University School of Medicine, 801 Norther Rutledge, Springfield, IL 62794en_US
dc.identifier.pmid22434653en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/91367/1/22827_ftp.pdf
dc.identifier.doi10.1002/jnr.22827en_US
dc.identifier.sourceJournal of Neuroscience Researchen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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