Ki-67 Expression in Breast Cancer; Its Association with Grading Systems, Clinical Parameters and Other Prognostic Factors -- A Surrogate Marker?
dc.contributor.author | Trihia, Helen | |
dc.contributor.author | Murray, Susan | |
dc.contributor.author | Price, Karen | |
dc.contributor.author | Gelber, Richard D. | |
dc.contributor.author | Golouh, Rastko | |
dc.contributor.author | Goldhirsch, Aron | |
dc.contributor.author | Coates, Alan S. | |
dc.contributor.author | Collins, John | |
dc.contributor.author | Castiglione-Gertsch, Monica | |
dc.contributor.author | Gusterson, Barry | |
dc.date.accessioned | 2012-07-01T21:53:43Z | |
dc.date.available | 2012-07-01T21:53:43Z | |
dc.date.issued | 2003-03-01 | |
dc.identifier.citation | Cancer 2003 vol. 97 no. 5, pp. 1321-1331. <http://hdl.handle.net/2027.42/91948> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/91948 | |
dc.description.abstract | BACKGROUND. The number of mitoses and, thus, the proliferative capacity of a tumor is one of the most crucial variables for tumor grading. The Ki-67 nuclear antigen may be considered as an alternative to mitotic counts in grading schemes and as a single parameter that can be used in fine-needle aspirates and small biopsies. METHODS. Immunohistochemistry using the anti-Ki-67 antibody MIB-1 was performed on 434 breast carcinoma specimens from the International Breast Cancer Study Group (formerly Ludwig) Trial V. Three groups based on Ki-67 percent were used to replace the mitotic counts component in the Nottingham grade (NHG) to produce the Nottingham/Ki-67 grade (NKG) and to assess Ki-67 as a single parameter. RESULTS. In both the lymph node positive subgroup and the lymph node negative subgroup, the NKG and Ki-67 group was correlated significantly with Bloom– Richardson grade (BRG), NHG, and Nottingham type. Tumor size in the lymph node negative cohort and estrogen receptor status, progesterone receptor status, and c-erbB-2 expression in the lymph node positive cohort also were correlated significantly with NKG. Ki-67 percentage was correlated significantly with c-erbB-2 expression in the lymph node positive cohort only. NKG was similar to BRG and NHG when it was evaluated for prognostic significance. Patients with higher categoric Ki-67 percentages had worse overall and disease free survival in all groups except for the untreated, lymph node negative group. CONCLUSIONS. Ki-67 detection represents a valuable tool and is a good objective substitute for mitotic counts when used in a grading system. When it is used alone, Ki-67 detection provides valuable information, although it is necessary to combine this with other parameters in the study of core biopsies and fine-needle aspirates. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Ki-67 | en_US |
dc.subject | MIB-1 | en_US |
dc.subject | Breast Carcinoma | en_US |
dc.subject | Histologic Grade | en_US |
dc.subject | Nottingham Grade | en_US |
dc.subject | Bloom–Richardson Grade | en_US |
dc.title | Ki-67 Expression in Breast Cancer; Its Association with Grading Systems, Clinical Parameters and Other Prognostic Factors -- A Surrogate Marker? | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biostatistics | en_US |
dc.contributor.affiliationother | International Breast Cancer Study Group Pathology Center, Western Infirmary, Glasgow, United Kingdom. | en_US |
dc.contributor.affiliationother | International Breast Cancer Study Group Statistical Center, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | Frontier Science and Technology Research Foundation, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | Department of Biostatistical Science, Dana Farber Cancer Institute, Boston, Massachusetts. | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/91948/1/2003 Cancer Ki-67 Expression in Breast Carcinoma.pdf | |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Public Health, School of (SPH) |
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