Mesenchymal stromal cells in bronchoalveolar lavage as predictors of bronchiolitis obliterans syndrome
dc.contributor.author | Badri, Linda | |
dc.contributor.author | Murray, Susan | |
dc.contributor.author | Liu, Lyrica X. | |
dc.contributor.author | Walker, Natalie M. | |
dc.contributor.author | Flint, Andrew | |
dc.contributor.author | Wadhwa, Anish | |
dc.contributor.author | Chan, Kevin | |
dc.contributor.author | Toews, Galen B. | |
dc.contributor.author | Pinsky, David J. | |
dc.contributor.author | Martinez, Fernando J. | |
dc.contributor.author | Lama, Vibha N. | |
dc.date.accessioned | 2012-07-02T19:27:23Z | |
dc.date.available | 2012-07-02T19:27:23Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | American Journal of Respiratory and Critical Care Medicine 2011. vol. 183, pp. 1062-1070. <http://hdl.handle.net/2027.42/91951> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/91951 | |
dc.description.abstract | Rationale: Bronchoalveolar lavage fluid (BAL) from human lung allografts demonstrates the presence of a multipotentmesenchymal stromal cell population. However, the clinical relevance of this novel cellular component of BAL and its association with bronchiolitis obliterans syndrome (BOS), a disease marked by progressive airflow limitation secondary to fibrotic obliteration of the small airways, remains to be determined. Objectives: In this study we investigate the association of number of mesenchymal stromal cells in BAL with development of BOS in human lung transplant recipients. Methods:Mesenchymal colony-forming units (CFUs)were quantitated in a cohort of 405 BAL samples obtained from 162 lung transplant recipients. Poisson generalized estimating equations were used to determine the predictors of BAL mesenchymal CFU count. Measurements and Main Results: Higher CFU counts were noted early post-transplantation; time from transplant to BAL of greater than 3 months predicted 0.4-fold lower CFU counts (P = 0.0001). BOS diagnosis less than or equal to 365 days before BAL was associated with a 2.11-fold higher CFU count (P = 0.02). There were 2.62- and 2.70-fold higher CFU counts noted in the presence of histologic diagnosis of bronchiolitis obliterans (P = 0.05) and organizing pneumonia (0.0003), respectively. In BAL samples obtained from BOS-free patients greater than 6 months post-transplantation (n = 173), higher mesenchymal CFU counts (>=10) significantly predicted BOS onset in both univariate (hazard ratio, 5.61; 95%CI, 3.03–10.38; P < 0.0001) andmultivariate (hazard ratio, 5.02; 95%CI, 2.40–10.51; P < 0.0001) Cox regression analysis. Conclusions: Measurement of mesenchymal CFUs in the BAL provides predictive information regarding future BOS onset. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Bronchiolitis Obliterans Syndrome | en_US |
dc.subject | Acute Rejection | en_US |
dc.subject | Bronchoalveolar Lavage | en_US |
dc.subject | Lung Transplantation | en_US |
dc.title | Mesenchymal stromal cells in bronchoalveolar lavage as predictors of bronchiolitis obliterans syndrome | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Department of Biostatistics, Department of Pathology | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/91951/1/2011 AJRCCM Mesenchymal stromal cells in bronchoalveolar lavage as predictors of bronchiolitis obliterans syndrome.pdf | |
dc.identifier.source | American Journal of Respiratory and Critical Care Medicine | en_US |
dc.owningcollname | Public Health, School of (SPH) |
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