Clinical Predictors of a Diagnosis of Idiopathic Pulmonary Fibrosis
dc.contributor.author | Fell, Charlene D. | |
dc.contributor.author | Martinez, Fernando J. | |
dc.contributor.author | Liu, Lyrica X. | |
dc.contributor.author | Murray, Susan | |
dc.contributor.author | Han, MeiLan K. | |
dc.contributor.author | Kazerooni, Ella A. | |
dc.contributor.author | Gross, Barry H. | |
dc.contributor.author | Myers, Jeffrey | |
dc.contributor.author | Travis, William D. | |
dc.contributor.author | Colby, Thomas V. | |
dc.contributor.author | Toews, Galen B. | |
dc.contributor.author | Flaherty, K. R. | |
dc.date.accessioned | 2012-07-02T21:51:53Z | |
dc.date.available | 2012-07-02T21:51:53Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | American Journal of Respiratory and Critical Care Medicine 2010. vol. 181, pp. 832-837. <http://hdl.handle.net/2027.42/91953> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/91953 | |
dc.description.abstract | Rationale: Idiopathic pulmonary fibrosis (IPF) and other idiopathic interstitial pneumonias (IIPs) have similar clinical and radiographic features, but their histopathology, response to therapy, and natural history differ. A surgical lung biopsy is often required to distinguish between these entities. Objectives: We sought to determine if clinical variables could predict a histopathologic diagnosis of IPF in patients without honeycomb change on high-resolution computed tomography (HRCT). Methods: Data from 97 patients with biopsy-proven IPF and 38 patients with other IIPs were examined. Logistic regression models were built to identify the clinical variables that predict histopathologic diagnosis of IPF. Measurements and Main Results: Increasing age and average total HRCT interstitial score on HRCT scan of the chest may predict a biopsy confirmation of IPF. Sex, pulmonary function, presence of desaturation, or distance walked during a 6-minute walk test did not help discriminate pulmonary fibrosis from other IIPs. Conclusions: Clinical data may be used to predict a diagnosis of IPF over other IIPs. Validation of these data with a prospective study is needed. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Idiopathic Pulmonary Fibrosis | en_US |
dc.subject | Idiopathic Interstitial Pneumonia | en_US |
dc.subject | Diagnosis | en_US |
dc.subject | Computed Tomography of the Chest | en_US |
dc.title | Clinical Predictors of a Diagnosis of Idiopathic Pulmonary Fibrosis | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Pulmonary and Critical Care Medicine, Department of Radiology, Division of Cardiothoracic Radiology, Department of Pathology, Department of Biostatistics | en_US |
dc.contributor.affiliationother | Division of Respiratory Medicine, University of Calgary | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/91953/1/2010 AJRCCM Clinical Predictors of a Diagnosis of Idiopathic Pulmonary Fibrosis.pdf | |
dc.identifier.source | American Journal of Respiratory and Critical Care Medicine | en_US |
dc.owningcollname | Public Health, School of (SPH) |
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