Sex differences in physiological progression of idiopathic pulmonary fibrosis
dc.contributor.author | Han, MeiLan K. | |
dc.contributor.author | Murray, Susan | |
dc.contributor.author | Fell, Charlene D. | |
dc.contributor.author | Flaherty, Kevin R. | |
dc.contributor.author | Toews, Galen B. | |
dc.contributor.author | Myers, Jeffrey L. | |
dc.contributor.author | Colby, Thomas V. | |
dc.contributor.author | Travis, William D | |
dc.contributor.author | Kazerooni, Ella A. | |
dc.contributor.author | Gross, Barry H. | |
dc.contributor.author | Martinez, Fernando J. | |
dc.date.accessioned | 2012-07-04T01:12:58Z | |
dc.date.available | 2012-07-04T01:12:58Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | European Respiratory Journal 2008 vol. 31 no. 6, pp. 1183 – 1188 <http://hdl.handle.net/2027.42/91966> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/91966 | |
dc.description.abstract | In idiopathic pulmonary fibrosis, incidence is higher in males, and females may have better survival. The aim of the present study was to determine whether the rate of increase in desaturation during serial 6-min walk testing would be greater, and survival worse, for males versus females. Serial changes in the percentage of maximum desaturation area (DA) over 1 yr were estimated using mixed models in 215 patients. DA was defined as the total area above the curve created using desaturation percentage values observed during each minute of the 6-min walk test. Multivariate Cox regression assessed survival differences. Adjusting for baseline DA, 6-min walk distance, change in 6-min walk distance over time and smoking history, the percentage of maximum DA increased by an average of 2.83 and 1.37% per month for males and females, respectively. Females demonstrated better survival overall, which was more pronounced in patients who did not desaturate below 88% on ambulation at baseline and after additionally adjusting for 6-month relative changes in DA and forced vital capacity. These data suggest that differences in disease progression contribute to, but do not completely explain, better survival of females with idiopathic pulmonary fibrosis. | en_US |
dc.description.sponsorship | This work was supported by National Institutes of Health grants 5P50HL56402, U10HL080371, 2K24HL04212, K12RR024987 and K23HL68713, and the Alberta Heritage Medical Foundation. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Desaturation | en_US |
dc.subject | Interstitial Lung Disease | en_US |
dc.subject | 6-min Walk Test | en_US |
dc.subject | Survival | en_US |
dc.title | Sex differences in physiological progression of idiopathic pulmonary fibrosis | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/91966/1/2008 ERJ - Sex Differences in Physiologic Progression of Idiopathic Pulmonary Fibrosis.pdf | |
dc.identifier.source | European Respiratory Journal | en_US |
dc.owningcollname | Public Health, School of (SPH) |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.