Sex Differences in Severe Pulmonary Emphysema
dc.contributor.author | Martinez, Fernando J. | |
dc.contributor.author | Curtis, Jeffrey L. | |
dc.contributor.author | Sciurba, Frank | |
dc.contributor.author | Mumford, Jeanette | |
dc.contributor.author | Giardino, Nicholas D. | |
dc.contributor.author | Weinmann, Gail | |
dc.contributor.author | Kazerooni, Ella A. | |
dc.contributor.author | Murray, Susan | |
dc.contributor.author | Criner, Gerard J. | |
dc.contributor.author | Sin, Donald D. | |
dc.contributor.author | Hogg, James | |
dc.contributor.author | Ries, Andrew L. | |
dc.contributor.author | Han, MeiLan K. | |
dc.contributor.author | Fishman, Alfred P. | |
dc.contributor.author | Make, Barry J. | |
dc.contributor.author | Hoffman, Eric A. | |
dc.contributor.author | Mohsenifar, Zab | |
dc.contributor.author | Wise, Robert | |
dc.contributor.author | National Emphysema Treatment Trial Research Group | |
dc.date.accessioned | 2012-07-06T00:59:00Z | |
dc.date.available | 2012-07-06T00:59:00Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | American Journal of Respiratory and Critical Care Medicine 2007. vol. 176, pp. 243-252. <http://hdl.handle.net/2027.42/91968> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/91968 | |
dc.description.abstract | Rationale: Limited data on sex differences in advanced COPD are available. Objectives: To compare male and female emphysema patients with severe disease. Methods: One thousand fifty-three patients (38.8% female) evaluated for lung volume reduction surgery as part of the National Emphysema Treatment Trial were analyzed. Measurements and Main Results: Detailed clinical, physiological, and radiological assessment, including quantitation of emphysema severity and distribution from helical chest computed tomography, was completed. In a subgroup (n = 101), airway size and thickness was determined by histological analyses of resected tissue. Women were younger and exhibited a lower bodymass index (BMI), shorter smoking history, less severe airflow obstruction, lower DLCO and arterial PO2, higher arterial PCO2, shorter six-minute walk distance, and lower maximal wattage during oxygen-supplemented cycle ergometry. For a given FEV1% predicted, age, number of packyears, and proportion of emphysema, women experienced greater dyspnea, higher modified BODE, more depression, lower SF-36 mental component score, and lower quality of well-being. Overall emphysema was less severe in women, with the difference from men most evident in the outer peel of the lung. Females had thicker small airway walls relative to luminal perimeters. Conclusions: In patients with severe COPD, women, relative to men, exhibit anatomically smaller airway lumens with disproportionately thicker airway walls, and emphysema that is less extensive and characterized by smaller hole size and less peripheral involvement. | en_US |
dc.description.sponsorship | The National Emphysema Treatment Trial (NETT) was supported by contracts with the National Heart, Lung, and Blood Institute (N01HR76101, N01HR76102, N01HR76103, N01HR76104, N01HR76105, N01HR76106, N01HR76107, N01HR76108, N01HR76109, N01HR76110, N01HR76111, N01HR76112, N01HR76113, N01HR76114, N01HR76115, N01HR76116, N01HR76118, and N01HR76119); the Centers for Medicare and Medicaid Services (CMS; formerly the Health Care Financing Administration); and the Agency for Healthcare Research and Quality (AHRQ). J.L.C. is supported by funding from a Research Enhancement Award Program (REAP) from the Biomedical Laboratory Research & Development Service, Department of Veterans Affairs. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Chronic Obstructive Pulmonary Disease | en_US |
dc.subject | Emphysema | en_US |
dc.subject | Computed Tomography | en_US |
dc.subject | Pulmonary Function | en_US |
dc.subject | Gender | en_US |
dc.title | Sex Differences in Severe Pulmonary Emphysema | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Pulmonary and Critical Care Medicine, Department of Biostatistics, Department of Psychiatry, Department of Radiology | en_US |
dc.contributor.affiliationother | University of Pittsburgh, Division of Pulmonary and Critical Care Medicine, Pittsburgh, Pennsylvania | en_US |
dc.contributor.affiliationother | National Heart, Lung and Blood Institute, Division of Lung Diseases, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | Temple University, Division of Pulmonary and Critical Care Medicine, Philadelphia, Pennsylvania | en_US |
dc.contributor.affiliationother | University of British Columbia, Respiratory Department, Vancouver, British Columbia, Canada | en_US |
dc.contributor.affiliationother | University of California, Department of Medicine, San Diego, California | en_US |
dc.contributor.affiliationother | University of Pennsylvania, Office of Program Development, Philadelphia, Pennsylvania | en_US |
dc.contributor.affiliationother | National Jewish Medical & Research Center, Division of Pulmonary Sciences and Critical Care Medicine, Denver, Colorado | en_US |
dc.contributor.affiliationother | University of Iowa, Department of Radiology, Iowa City, Iowa | en_US |
dc.contributor.affiliationother | Cedars-Sinai Medical Center, Division of Pulmonary Medicine, Los Angeles, California | en_US |
dc.contributor.affiliationother | Johns Hopkins University, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/91968/1/2007 Martinez AJRCCM Sex Differences in Empy.pdf | |
dc.identifier.source | American Journal of Respiratory and Critical Care Medicine | en_US |
dc.owningcollname | Public Health, School of (SPH) |
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