Prognostic value of desaturation during a six minute walk test in Idiopathic Interstitial Pneumonia
dc.contributor.author | Lama, Vibha N. | |
dc.contributor.author | Flaherty, Kevin R. | |
dc.contributor.author | Toews, Galen B. | |
dc.contributor.author | Colby, Thomas V. | |
dc.contributor.author | Travis, William D. | |
dc.contributor.author | Long, Qi | |
dc.contributor.author | Murray, Susan | |
dc.contributor.author | Kazerooni, Ella A. | |
dc.contributor.author | Gross, Barry H. | |
dc.contributor.author | Lynch, Joseph P. III | |
dc.contributor.author | Martinez, Fernando J. | |
dc.date.accessioned | 2012-07-06T08:44:36Z | |
dc.date.available | 2012-07-06T08:44:36Z | |
dc.date.issued | 2003-11-01 | |
dc.identifier.citation | American Journal of Respiratory and Critical Care Medicine 2003. vol. 168 no. 9, pp. 1084-1090 <http://hdl.handle.net/2027.42/91972> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/91972 | |
dc.description.abstract | Exercise-induced hypoxia is an index of the severity of interstitial lung disease. We hypothesized that desaturation during a 6-minute walk test would predict mortality for patients with usual interstitial pneumonia (n = 83) and nonspecific interstitial pneumonia (n = 22). Consecutive patients with biopsy-proven disease performed a 6-minute walk test between January 1996 and December 2001. Desaturation was defined as a fall in oxygen saturation to 88% or less during the 6-minute walk test. Desaturation was common (44 of 83 usual interstitial pneumonia and 8 of 22 nonspecific interstitial pneumonia; chi square, p = 0.39). Patients with usual interstitial pneumonia or nonspecific interstitial pneumonia who desaturated had a significantly higher mortality than patients who did not desaturate (respective log-rank tests, p = 0.0018, p = 0.0089). In patients with usual interstitial pneumonia, the presence of desaturation was associated with an increased hazard of death (hazard ratio, 4.2; 95% confidence interval, 1.40, 12.56; p = 0.01) after adjusting for age, sex, smoking, baseline diffusion capacity for carbon monoxide, FVC, and resting saturation.Weconclude that knowledge of desaturation during a 6-minute walk test adds prognostic information for patients with usual interstitial pneumonia and nonspecific interstitial pneumonia. | en_US |
dc.description.sponsorship | Supported in part by National Institutes of Health NHLBI Grant #P50HL46487, NHLBI, 1 K24 HL04212, and 1 K23 HL68713. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | 6-minute Walk Test | en_US |
dc.subject | Usual Interstitial Pneumonia | en_US |
dc.subject | Nonspecific Interstitial Pneumonia | en_US |
dc.title | Prognostic value of desaturation during a six minute walk test in Idiopathic Interstitial Pneumonia | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Pulmonary and Critical Care Medicine, Department of Radiology, Department of Biostatistics | en_US |
dc.contributor.affiliationother | Armed Forces Institute of Pathology, Mayo Clinic, Scottsdale, Arizona | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/91972/1/2003 AJRCCM - Prognostic value of desaturation during a six minute walk test in Idiopathic Interstitial Pneumonia.pdf | |
dc.identifier.source | American Journal of Respiratory and Critical Care Medicine | en_US |
dc.owningcollname | Public Health, School of (SPH) |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.