Fibroblastic Foci in Usual Interstitial Pneumonia: Idiopathic versus Collagen Vascular Disease
dc.contributor.author | Flaherty, Kevin R. | |
dc.contributor.author | Colby, Thomas V. | |
dc.contributor.author | Travis, William D. | |
dc.contributor.author | Toews, Galen B. | |
dc.contributor.author | Mumford, Jeanette A. | |
dc.contributor.author | Murray, Susan | |
dc.contributor.author | Thannickal, Victor J. | |
dc.contributor.author | Kazerooni, Ella A. | |
dc.contributor.author | Gross, Barry H. | |
dc.contributor.author | Lynch, Joseph P. III | |
dc.contributor.author | Martinez, Fernando J. | |
dc.date.accessioned | 2012-07-06T12:05:31Z | |
dc.date.available | 2012-07-06T12:05:31Z | |
dc.date.issued | 2003-05-15 | |
dc.identifier.citation | American Journal of Respiratory and Critical Care Medicine 2003. vol. 167, pp. 1410-1415 <http://hdl.handle.net/2027.42/91974> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/91974 | |
dc.description.abstract | A histologic feature of usual interstitial pneumonia is the presence of fibroblastic foci. As some patients with usual interstitial pneumonia and an underlying collagen vascular disease have a better prognosis, we hypothesized that they would have fewer fibroblastic foci. Pathologists reviewed surgical lung biopsies from 108 patients with usual interstitial pneumonia (nine with collagen vascular disease) and assigned a score (absent 0, mild 1, moderate 2, and marked 3) for fibroblastic foci. Patients with idiopathic usual interstitial pneumonia had a higher median profusion of fibroblastic foci (1.75 vs. 1.0, p = 0.003). Baseline characteristics were similar, although patients with a collagen vascular disease were younger, had a shorter duration of symptoms, and had a higher percentage of predicted total lung capacity. Profusion of fibroblastic foci was the most discriminative feature for separating idiopathic from collagen vascular disease–associated usual interstitial pneumonia (odds ratio 8.31; 95% confidence interval, 1.98, 59.42; p = 0.002 for a one-unit increase in fibroblastic foci score). No deaths were noted in the collagen vascular disease–associated usual interstitial pneumonia group; 52 deaths occurred in the idiopathic usual interstitial pneumonia group (log rank; p = 0.005). We conclude that patients with collagen vascular disease–associated usual interstitial pneumonia have fewer fibroblastic foci and improved survival. | en_US |
dc.description.sponsorship | Supported in part by National Institutes of Health National Heart, Lung, and Blood Institute grant #P50HL46487, NIH/NCRR 3 MO1 RR00042–33S3, NIH/NIA P60 AG08808–06, NHLBI 1 K24 HL04212, and 1 K23 HL68713. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Idiopathic Pulmonary Fibrosis | en_US |
dc.subject | Usual Interstitial Pneumonia | en_US |
dc.subject | Nonspecific Interstitial Pneumonia | en_US |
dc.subject | Fibroblastic Focus | en_US |
dc.title | Fibroblastic Foci in Usual Interstitial Pneumonia: Idiopathic versus Collagen Vascular Disease | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiology, Division of Pulmonary and Critical Care Medicine, Department of Biostatistics | en_US |
dc.contributor.affiliationother | Armed Forces Institute of Pathology, Washington, DC | en_US |
dc.contributor.affiliationother | Mayo Clinic, Scottsdale, Arizona | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/91974/1/2003 AJRCCM - Fibroblastic Foci in Usual Interstitial Pneumonia -Idiopathic versus Collagen Vascular Disease.pdf | |
dc.identifier.source | American Journal of Respiratory and Critical Care Medicine | en_US |
dc.owningcollname | Public Health, School of (SPH) |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.