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Functionalized Synthetic Biodegradable Polymer Scaffolds for Tissue Engineering
dc.contributor.authorLiu, Xiaohuaen_US
dc.contributor.authorHolzwarth, Jeremy M.en_US
dc.contributor.authorMa, Peter X.en_US
dc.date.accessioned2012-07-12T17:23:18Z
dc.date.available2013-09-03T15:38:27Zen_US
dc.date.issued2012-07en_US
dc.identifier.citationLiu, Xiaohua; Holzwarth, Jeremy M.; Ma, Peter X. (2012). "Functionalized Synthetic Biodegradable Polymer Scaffolds for Tissue Engineering." Macromolecular Bioscience 12(7): 911-919. <http://hdl.handle.net/2027.42/92034>en_US
dc.identifier.issn1616-5187en_US
dc.identifier.issn1616-5195en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/92034
dc.description.abstractScaffolds (artificial ECMs) play a pivotal role in the process of regenerating tissues in 3D. Biodegradable synthetic polymers are the most widely used scaffolding materials. However, synthetic polymers usually lack the biological cues found in the natural extracellular matrix. Significant efforts have been made to synthesize biodegradable polymers with functional groups that are used to couple bioactive agents. Presenting bioactive agents on scaffolding surfaces is the most efficient way to elicit desired cell/material interactions. This paper reviews recent advancements in the development of functionalized biodegradable polymer scaffolds for tissue engineering, emphasizing the syntheses of functional biodegradable polymers, and surface modification of polymeric scaffolds. Significant efforts have been made to develop functional biodegradable scaffolds for tissue regeneration that can enhance cell function and guide new tissue formation. This paper discusses the recent advancements of functionalizing synthetic biodegradable polymer scaffolds, focusing on polymer synthesis, surface modification, and cellular response on these functionalized scaffolds.en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.subject.otherCell Adhesionen_US
dc.subject.otherBiodegradable Polymersen_US
dc.subject.otherTissue Engineeringen_US
dc.subject.otherSurface Modificationen_US
dc.subject.otherScaffoldsen_US
dc.titleFunctionalized Synthetic Biodegradable Polymer Scaffolds for Tissue Engineeringen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelMaterials Science and Engineeringen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.en_US
dc.contributor.affiliationumMacromolecular Science and Engineering Center, and Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherDepartment of Biomedical Sciences, Baylor College of Dentistry, Texas A&M HSC, Dallas, TX 75246, USAen_US
dc.identifier.pmid22396193en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/92034/1/911_ftp.pdf
dc.identifier.doi10.1002/mabi.201100466en_US
dc.identifier.sourceMacromolecular Bioscienceen_US
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