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Development of Channeled Nanofibrous Scaffolds for Oriented Tissue Engineering
dc.contributor.authorSun, Chenghuien_US
dc.contributor.authorJin, Xiaobingen_US
dc.contributor.authorHolzwarth, Jeremy M.en_US
dc.contributor.authorLiu, Xiaohuaen_US
dc.contributor.authorHu, Jiangen_US
dc.contributor.authorGupte, Melanie J.en_US
dc.contributor.authorZhao, Yaomingen_US
dc.contributor.authorMa, Peter X.en_US
dc.date.accessioned2012-07-12T17:23:47Z
dc.date.available2013-08-01T14:04:40Zen_US
dc.date.issued2012-06en_US
dc.identifier.citationSun, Chenghui; Jin, Xiaobing; Holzwarth, Jeremy M.; Liu, Xiaohua; Hu, Jiang; Gupte, Melanie J.; Zhao, Yaoming; Ma, Peter X. (2012). "Development of Channeled Nanofibrous Scaffolds for Oriented Tissue Engineering." Macromolecular Bioscience 12(6): 761-769. <http://hdl.handle.net/2027.42/92054>en_US
dc.identifier.issn1616-5187en_US
dc.identifier.issn1616-5195en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/92054
dc.description.abstractA tissue‐engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro‐scale tissue bundles. In this study, a method combining injection molding and thermally induced phase separation techniques is developed to create single‐ and multiple‐channeled nanofibrous poly( L ‐lactic acid) scaffolds. The overall shape, the number and spatial arrangement of channels, the channel wall matrix architecture, the porosity and mechanical properties of the scaffolds are all tunable. The porous NF channel wall matrix provides an excellent microenvironment for protein adsorption and the attachment of PC12 neuronal cells and tendon fibroblast cells, showing potential for neural and tendon tissue regeneration. A method combining injection molding and thermally induced phase separation is developed to create single‐ and multiple‐channeled nanofibrous polymer scaffolds. The porous nanofibrous channel wall provides an excellent microenvironment for protein adsorption and cell attachment, showing potential for nerve and tendon regeneration.en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.subject.otherFibersen_US
dc.subject.otherNervesen_US
dc.subject.otherScaffoldsen_US
dc.subject.otherTendonsen_US
dc.subject.otherTissue Engineeringen_US
dc.titleDevelopment of Channeled Nanofibrous Scaffolds for Oriented Tissue Engineeringen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelMaterials Science and Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.en_US
dc.contributor.affiliationumDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumMacromolecular Science and Engineering Center, Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherCollege of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, Chinaen_US
dc.identifier.pmid22508530en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/92054/1/761_ftp.pdf
dc.identifier.doi10.1002/mabi.201200004en_US
dc.identifier.sourceMacromolecular Bioscienceen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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