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Clinical‐histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium
dc.contributor.authorGrover, M.en_US
dc.contributor.authorBernard, C. E.en_US
dc.contributor.authorPasricha, P. J.en_US
dc.contributor.authorLurken, M. S.en_US
dc.contributor.authorFaussone‐pellegrini, M. S.en_US
dc.contributor.authorSmyrk, T. C.en_US
dc.contributor.authorParkman, H. P.en_US
dc.contributor.authorAbell, T. L.en_US
dc.contributor.authorSnape, W. J.en_US
dc.contributor.authorHasler, W. L.en_US
dc.contributor.authorMcCallum, R. W.en_US
dc.contributor.authorNguyen, L.en_US
dc.contributor.authorKoch, K. L.en_US
dc.contributor.authorCalles, J.en_US
dc.contributor.authorLee, L.en_US
dc.contributor.authorTonascia, J.en_US
dc.contributor.authorÜnalp‐arida, A.en_US
dc.contributor.authorHamilton, F. A.en_US
dc.contributor.authorFarrugia, G.en_US
dc.date.accessioned2012-07-12T17:25:17Z
dc.date.available2013-08-01T14:04:40Zen_US
dc.date.issued2012-06en_US
dc.identifier.citationGrover, M.; Bernard, C. E.; Pasricha, P. J.; Lurken, M. S.; Faussone‐pellegrini, M. S. ; Smyrk, T. C.; Parkman, H. P.; Abell, T. L.; Snape, W. J.; Hasler, W. L.; McCallum, R. W.; Nguyen, L.; Koch, K. L.; Calles, J.; Lee, L.; Tonascia, J.; Ünalp‐arida, A. ; Hamilton, F. A.; Farrugia, G. (2012). "Clinicalâ histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium." Neurogastroenterology & Motility 24(6). <http://hdl.handle.net/2027.42/92097>en_US
dc.identifier.issn1350-1925en_US
dc.identifier.issn1365-2982en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/92097
dc.description.abstractBackground  Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium. The association of these cellular changes with gastroparesis symptoms and gastric emptying is unknown. The aim of this study was to relate cellular changes to symptoms and gastric emptying in patients with gastroparesis. Methods  Earlier, using full thickness gastric body biopsies from 20 DG, 20 IG, and 20 matched controls, we found decreased interstitial cells of Cajal (ICC) and enteric nerves and an increase in immune cells in both DG and IG. Here, demographic, symptoms [gastroparesis cardinal symptom index score (GCSI)], and gastric emptying were related to cellular alterations using Pearson’s correlation coefficients. Key Results  Interstitial cells of Cajal counts inversely correlated with 4 h gastric retention in DG but not in IG (r = −0.6, P  = 0.008, DG, r = 0.2, P  = 0.4, IG). There was also a significant correlation between loss of ICC and enteric nerves in DG but not in IG (r = 0.5, P  = 0.03 for DG, r = 0.3, P  = 0.16, IG). Idiopathic gastroparesis with a myenteric immune infiltrate scored higher on the average GCSI (3.6 ± 0.7 vs 2.7 ± 0.9, P  = 0.05) and nausea score (3.8 ± 0.9 vs 2.6 ± 1.0, P  = 0.02) as compared to those without an infiltrate. Conclusions & Inferences  In DG, loss of ICC is associated with delayed gastric emptying. Interstitial cells of Cajal or enteric nerve loss did not correlate with symptom severity. Overall clinical severity and nausea in IG is associated with a myenteric immune infiltrate. Thus, full thickness gastric biopsies can help define specific cellular abnormalities in gastroparesis, some of which are associated with physiological and clinical characteristics of gastroparesis.en_US
dc.publisherBlackwell Publishing Ltden_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherClinical Symptomsen_US
dc.subject.otherMacrophagesen_US
dc.subject.otherInterstitial Cells of Cajalen_US
dc.subject.otherGastroparesisen_US
dc.subject.otherGastric Emptyingen_US
dc.subject.otherEnteric Nervous Systemen_US
dc.titleClinical‐histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortiumen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherMayo Clinic, Rochester, MN, USAen_US
dc.contributor.affiliationotherStanford University, Palo Alto, CA, USAen_US
dc.contributor.affiliationotherUniversity of Florence, Florence, Italyen_US
dc.contributor.affiliationotherTemple University, Philadelphia, PA, USAen_US
dc.contributor.affiliationotherUniversity of Mississippi, Jackson, MS, USAen_US
dc.contributor.affiliationotherCalifornia Pacific Medical Center, San Francisco, CA, USAen_US
dc.contributor.affiliationotherTexas Tech University Health Sciences Center, TX, USAen_US
dc.contributor.affiliationotherWake Forest University, Winston‐Salem, NC, USAen_US
dc.contributor.affiliationotherJohns Hopkins University, Baltimore, MD, USAen_US
dc.contributor.affiliationotherNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/92097/1/j.1365-2982.2012.01894.x.pdf
dc.identifier.doi10.1111/j.1365-2982.2012.01894.xen_US
dc.identifier.sourceNeurogastroenterology & Motilityen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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