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Solvent exposures and parkinson disease risk in twins
dc.contributor.authorGoldman, Samuel M.en_US
dc.contributor.authorQuinlan, Patricia J.en_US
dc.contributor.authorRoss, G. Websteren_US
dc.contributor.authorMarras, Connieen_US
dc.contributor.authorMeng, Cherylen_US
dc.contributor.authorBhudhikanok, Grace S.en_US
dc.contributor.authorComyns, Kathleenen_US
dc.contributor.authorKorell, Monicaen_US
dc.contributor.authorChade, Anabel R.en_US
dc.contributor.authorKasten, Meikeen_US
dc.contributor.authorPriestley, Benjaminen_US
dc.contributor.authorChou, Kelvin L.en_US
dc.contributor.authorFernandez, Hubert H.en_US
dc.contributor.authorCambi, Francaen_US
dc.contributor.authorLangston, J. Williamen_US
dc.contributor.authorTanner, Caroline M.en_US
dc.date.accessioned2012-07-12T17:25:34Z
dc.date.available2013-08-01T14:04:40Zen_US
dc.date.issued2012-06en_US
dc.identifier.citationGoldman, Samuel M.; Quinlan, Patricia J.; Ross, G. Webster; Marras, Connie; Meng, Cheryl; Bhudhikanok, Grace S.; Comyns, Kathleen; Korell, Monica; Chade, Anabel R.; Kasten, Meike; Priestley, Benjamin; Chou, Kelvin L.; Fernandez, Hubert H.; Cambi, Franca; Langston, J. William; Tanner, Caroline M. (2012). "Solvent exposures and parkinson disease risk in twins." Annals of Neurology 71(6): 776-784. <http://hdl.handle.net/2027.42/92108>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/92108
dc.description.abstractObjective: Several case reports have linked solvent exposure to Parkinson disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design. Methods: Ninety‐nine twin pairs discordant for PD ascertained from the National Academy of Sciences/National Research Council World War II Veteran Twins Cohort were interviewed regarding lifetime occupations and hobbies using detailed job task–specific questionnaires. Exposures to 6 specific solvents selected a priori were estimated by expert raters unaware of case status. Results: Ever exposure to trichloroethylene (TCE) was associated with significantly increased risk of PD (odds ratio [OR], 6.1; 95% confidence interval [CI] 1.2–33; p = 0.034), and exposure to perchloroethylene (PERC) and carbon tetrachloride (CCl 4 ) tended toward significance (respectively: OR, 10.5; 95% CI, 0.97–113; p = 0.053; OR, 2.3; 95% CI, 0.9–6.1; p = 0.088). Results were similar for estimates of exposure duration and cumulative lifetime exposure. Interpretation: Exposure to specific solvents may increase risk of PD. TCE is the most common organic contaminant in groundwater, and PERC and CCl 4 are also ubiquitous in the environment. Our findings require replication in other populations with well‐characterized exposures, but the potential public health implications are substantial. ANN NEUROL 2011en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.titleSolvent exposures and parkinson disease risk in twinsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan Health System, Department of Neurology, Ann Arbor, MIen_US
dc.contributor.affiliationotherUniversity of Lubeck, Department of Neurology, Lubeck, Germanyen_US
dc.contributor.affiliationotherParkinson's Institute, 675 Almanor Avenue, Sunnyvale, CA 94085en_US
dc.contributor.affiliationotherUniversity of Kentucky, Department of Neurology, Lexington, KYen_US
dc.contributor.affiliationotherCleveland Clinic, Center for Neurology Restoration, Cleveland, OHen_US
dc.contributor.affiliationotherThe Parkinson's Institute, Sunnyvale, CAen_US
dc.contributor.affiliationotherDepartment of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco, CAen_US
dc.contributor.affiliationotherVeterans Affairs Pacific Islands Health Care System, Honolulu, HIen_US
dc.contributor.affiliationotherToronto Western Hospital, University of Toronto, Toronto, Ontario, Canadaen_US
dc.contributor.affiliationotherFavaloro University, Institute of Cognitive Neurology, and Institute of Neurosciences, Buenos Aires, Argentinaen_US
dc.identifier.pmid22083847en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/92108/1/22629_ftp.pdf
dc.identifier.doi10.1002/ana.22629en_US
dc.identifier.sourceAnnals of Neurologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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