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Olfactory identification testing as a predictor of the development of Alzheimer's dementia: A systematic review
dc.contributor.authorSun, Gordon H.en_US
dc.contributor.authorRaji, Cyrus A.en_US
dc.contributor.authorMacEachern, Mark P.en_US
dc.contributor.authorBurke, James F.en_US
dc.date.accessioned2012-07-12T17:26:05Z
dc.date.available2013-09-03T15:38:28Zen_US
dc.date.issued2012-07en_US
dc.identifier.citationSun, Gordon H.; Raji, Cyrus A.; MacEachern, Mark P.; Burke, James F. (2012). "Olfactory identification testing as a predictor of the development of Alzheimer's dementia: A systematic review ." The Laryngoscope 122(7): 1455-1462. <http://hdl.handle.net/2027.42/92127>en_US
dc.identifier.issn0023-852Xen_US
dc.identifier.issn1531-4995en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/92127
dc.description.abstractObjectives/Hypothesis: To evaluate the utility of olfactory identification tests as prognostic instruments for Alzheimer's dementia (AD). Study Design: Systematic review. Methods: In accordance with PRISMA guidelines, PubMed and Ovid MEDLINE, EMBASE, ISI Web of Science, PsycINFO, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials were searched to determine the quality and quantity of longitudinal and cross‐sectional research on this topic. Results: Two prospective longitudinal cohort studies and 30 cross‐sectional studies met inclusion criteria. The prospective longitudinal studies evaluated subjects with or without mild cognitive impairment (MCI) while also using olfactory identification testing as part of a neurocognitive evaluation. The first study reported an increased risk of later onset of AD in subjects with baseline hyposmia, whereas the second study suggested a possible relationship between decreased olfaction in participants with MCI and conversion to AD but was inconclusive due to low follow‐up rates. Wide variability in the type of olfactory identification test used and the reporting of results precluded meta‐analysis. The cross‐sectional studies demonstrated a positive association between poorer performance on olfactory identification testing and AD. Conclusions: Although there is evidence suggesting an association between decreased olfaction and AD, rigorously designed longitudinal cohort studies are necessary to clarify the value of olfactory identification testing in predicting the onset of AD.en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherHyposmiaen_US
dc.subject.otherAnosmiaen_US
dc.subject.otherLevel of Evidence: 2aen_US
dc.subject.otherAlzheimer's Diseaseen_US
dc.subject.otherMild Cognitive Impairmenten_US
dc.subject.otherOlfactionen_US
dc.subject.otherSmell Testen_US
dc.subject.otherScreeningen_US
dc.titleOlfactory identification testing as a predictor of the development of Alzheimer's dementia: A systematic reviewen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOtolaryngologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumRobert Wood Johnson Foundation Clinical Scholars , University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Otolaryngology–Head and Neck Surgery , University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumA. Alfred Taubman Health Sciences Library , University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Neurology , University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherVA Center for Clinical Management Research , VA Ann Arbor Healthcare System, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherDepartment of Radiology, University of California‐Los Angeles, Los Angeles, California, U.S.A.en_US
dc.contributor.affiliationother6312 Medical Science Building I, 1150 W. Medical Center Drive, SPC 5604, Ann Arbor, MI 48109‐5604en_US
dc.identifier.pmid22552846en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/92127/1/23365_ftp.pdf
dc.identifier.doi10.1002/lary.23365en_US
dc.identifier.sourceThe Laryngoscopeen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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