Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer
dc.contributor.author | Kapadia, Nirav S. | en_US |
dc.contributor.author | Mamet, Rizvan | en_US |
dc.contributor.author | Zornosa, Carrie | en_US |
dc.contributor.author | Niland, Joyce C. | en_US |
dc.contributor.author | D'Amico, Thomas A. | en_US |
dc.contributor.author | Hayman, James A. | en_US |
dc.date.accessioned | 2012-09-05T14:46:10Z | |
dc.date.available | 2013-10-18T17:47:29Z | en_US |
dc.date.issued | 2012-09-01 | en_US |
dc.identifier.citation | Kapadia, Nirav S.; Mamet, Rizvan; Zornosa, Carrie; Niland, Joyce C.; D'Amico, Thomas A.; Hayman, James A. (2012). "Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer ." Cancer 118(17): 4339-4345. <http://hdl.handle.net/2027.42/93552> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/93552 | |
dc.description.abstract | BACKGROUND: Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period. METHODS: Treatment characteristics of patients with incurable NSCLC who received RT at the EOL, defined as within 14 days of death, were analyzed from the National Comprehensive Cancer Network NSCLC Outcomes Database. RESULTS: Among 1098 patients who died, 10% had received EOL RT. Patients who did and did not receive EOL RT were similar in terms of sex, race, comorbid disease, and Eastern Cooperative Oncology Group performance status. On multivariable logistic regression analysis, independent predictors of receiving EOL RT included stage IV disease (odds ratio [OR], 2.04; 95% confidence interval [CI], 1.09‐3.83) or multiorgan involvement (OR, 1.75; 95% CI, 1.08‐2.84) at diagnosis, age <65 years at diagnosis (OR, 1.85; 95% CI, 1.21‐2.83), and treating institution (OR, 1.24‐5.94; P = .02). Nearly 50% of EOL RT recipients did not complete it, most commonly because of death or patient preference. CONCLUSIONS: In general, EOL RT was received infrequently, was delivered more commonly to younger patients with more advanced disease, and often was not completed as planned. There also was considerable variation in its use among National Comprehensive Cancer Network institutions. Next steps include expanding this research to other cancers and settings and investigating the clinical benefit of such treatment. Cancer 2012. © 2012 American Cancer Society. The authors characterize the use of radiotherapy in patients with incurable nonsmall cell lung cancer during their last 14 days of life and observe that its use is infrequent, it is delivered more commonly to younger patients with more advanced disease, and it is completed as planned only approximately half of the time. There is also significant institutional variation in its use; thus, future investigations should aim to expand this research to other cancers and settings and to investigate the clinical benefit of such treatment. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Radiotherapy | en_US |
dc.subject.other | Palliative Care | en_US |
dc.subject.other | Quality Indicators | en_US |
dc.subject.other | End‐Of‐Life Care | en_US |
dc.subject.other | Lung Cancer | en_US |
dc.title | Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, University of Michigan Hospital, 1500 E. Medical Center Drive, UHB2‐C490, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, University of Michigan Hospital, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | City of Hope Comprehensive Cancer Center, Duarte, California | en_US |
dc.contributor.affiliationother | National Comprehensive Cancer Network, Fort Washington, Pennsylvania | en_US |
dc.contributor.affiliationother | Duke Cancer Institute, Durham, North Carolina | en_US |
dc.identifier.pmid | 22252390 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/93552/1/27401_ftp.pdf | |
dc.identifier.doi | 10.1002/cncr.27401 | en_US |
dc.identifier.source | Cancer | en_US |
dc.identifier.citedreference | Konski A. Continuing evidence for poorer treatment outcomes for single male patients: retreatment data from RTOG 97‐14. Int J Radiat Oncol Biol Phys. 2006; 66: 229 ‐ 233. | en_US |
dc.identifier.citedreference | American Cancer Society. Cancer Facts & Figures 2010. Atlanta, GA: American Cancer Society; 2010. | en_US |
dc.identifier.citedreference | National Center for Health Statistics. SEER 9 Areas and US Mortality Files 2007. Atlanta, GA: National Center for Health Statistics, Centers for Disease Control and Prevention; 2007. Available from: http://seer.cancer.gov/csr/1975_2007/. Accessed November 1, 2010. | en_US |
dc.identifier.citedreference | Hayman JA, Abrahamse PH, Lakhani I, Earle CC, Katz SJ. Use of palliative radiotherapy among patients with metastatic non‐small‐cell lung cancer. Int J Radiat Oncol Biol Phys. 2007; 69: 1001 ‐ 1007. | en_US |
dc.identifier.citedreference | Earle CC, Neville BA, Landrum MB, et al. Evaluating claims‐based indicators of the intensity of end‐of‐life cancer care. Int J Qual Health Care. 2005; 17: 505 ‐ 509. | en_US |
dc.identifier.citedreference | Barbera L, Paszat L, Chartier C. Indicators of poor quality end‐of‐life cancer care in Ontario. J Palliat Care. 2006; 22: 12 ‐ 17. | en_US |
dc.identifier.citedreference | Horner MJ, Riesl AG, Krapcho M, eds. SEER Cancer Statistics Review, 1975‐2006 [based on the November 2008 SEER data submission, posted to the SEER web site 2009]. Bethesda, MD: National Cancer Institute; 2009. Available from: http://seer.cancer.gov/csr/1975_2006/. Accessed November 1, 2010. | en_US |
dc.identifier.citedreference | Huang J, Zhou S, Groome P, Tyldesley S, Zhang‐Solomans J, Mackillop WJ. Factors affecting the use of palliative radiotherapy in Ontario. J Clin Oncol. 2001; 19: 137 ‐ 144. | en_US |
dc.identifier.citedreference | Lavergne MR, Johnston G, Gao J, Dummer TJB, Rheaume DE. Variation in the use of palliative radiotherapy at end of life: examining demographic, clinical, health service, and geographic factors in a population‐based study. Palliat Med. 2010; 25: 101 ‐ 110. | en_US |
dc.identifier.citedreference | Hogan C. Medicare beneficiaries' costs of care in the last year of life. Health Aff (Millwood). 2001; 20: 188 ‐ 195. | en_US |
dc.identifier.citedreference | Temel JS, Greer JA, Muzikansky A, et al. Early palliative care for patients with metastatic non‐small‐cell lung cancer. N Engl J Med. 2010; 363: 733 ‐ 742. | en_US |
dc.identifier.citedreference | Johnston GM, Boyd CJ, Joseph P, MacIntyre M. Variation in delivery of palliative radiotherapy to persons dying of cancer in Nova Scotia, 1994 to 1998. J Clin Oncol. 2001; 19: 3323 ‐ 3332. | en_US |
dc.identifier.citedreference | Lutz S, Spence C, Chow E, Janjan N, Connor S. Survey on the use of palliative radiotherapy in hospice care. J Clin Oncol. 2004; 22: 3581 ‐ 3586. | en_US |
dc.identifier.citedreference | Gadgeel SM, Ramalingam S, Cummings G, et al. Lung cancer in patients ≤50 years of age: the experience of an academic multidisciplinary program. Chest. 1999; 115: 1232 ‐ 1236. | en_US |
dc.identifier.citedreference | Magne N, Chargari C, Mirimanoff RO, et al. European French‐speaking study from the GEMO group on bone metastases management: a special focus on external beam radiotherapy practice survey. Support Care Cancer. 2011; 19: 1565 ‐ 1572. | en_US |
dc.identifier.citedreference | Fairchild A, Barnes E, Ghosh S, et al. International patterns of practice in palliative radiotherapy for painful bone metastases: evidence‐based practice? Int J Radiat Oncol Biol Phys. 2009; 75: 1501 ‐ 1510. | en_US |
dc.identifier.citedreference | Rades D, Stalpers LJ, Hulshof MC, Zschenker O, Alberti W, Koning CC. Effectiveness and toxicity of single‐fraction radiotherapy with 1×8 Gy for metastatic spinal cord compression. Radiother Oncol. 2005; 75: 70 ‐ 73. | en_US |
dc.identifier.citedreference | Glare P, Virik K, Jones M, et al. A systematic review of physicians' survival predictions in terminally ill cancer patients. BMJ. 2003; 327: 195 ‐ 198. | en_US |
dc.identifier.citedreference | Forster LE, Lynn J. Predicting life span for applicants to inpatient hospice. Arch Intern Med. 1988; 148: 2540 ‐ 2543. | en_US |
dc.identifier.citedreference | Christakis N, Lamont EB. Extent and determinants of error in doctors' prognoses in terminally ill patients: prospective cohort study. BMJ. 2000; 320: 469 ‐ 472. | en_US |
dc.identifier.citedreference | Mackillop WJ, Quirt CF. Measuring the accuracy of prognostic judgments in oncology. J Clin Epidemiol. 1997; 50: 21 ‐ 29. | en_US |
dc.identifier.citedreference | Gripp S, Mjartan S, Boelke E, Willers R. Palliative radiotherapy tailored to life expectancy in end‐stage cancer patients: reality or myth? Cancer. 2010; 116: 3251 ‐ 3256. | en_US |
dc.identifier.citedreference | Erikson C. Future supply and demand for oncologists: challenges to assuring access to oncology services. J Oncol Pract. 2007; 3: 79 ‐ 86. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.