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UM‐SCC‐104: A New human papillomavirus‐16–positive cancer stem cell–containing head and neck squamous cell carcinoma cell line
dc.contributor.authorTang, Alice L.en_US
dc.contributor.authorHauff, Samantha J.en_US
dc.contributor.authorOwen, John H.en_US
dc.contributor.authorGraham, Martin P.en_US
dc.contributor.authorCzerwinski, Michael J.en_US
dc.contributor.authorPark, Jung Jeen_US
dc.contributor.authorWalline, Heatheren_US
dc.contributor.authorPapagerakis, Silvanaen_US
dc.contributor.authorStoerker, Jayen_US
dc.contributor.authorMcHugh, Jonathan B.en_US
dc.contributor.authorChepeha, Douglas B.en_US
dc.contributor.authorBradford, Carol R.en_US
dc.contributor.authorCarey, Thomas E.en_US
dc.contributor.authorPrince, Mark E.en_US
dc.date.accessioned2012-10-02T17:20:09Z
dc.date.available2013-11-04T19:53:16Zen_US
dc.date.issued2012-10en_US
dc.identifier.citationTang, Alice L.; Hauff, Samantha J.; Owen, John H.; Graham, Martin P.; Czerwinski, Michael J.; Park, Jung Je; Walline, Heather; Papagerakis, Silvana; Stoerker, Jay; McHugh, Jonathan B.; Chepeha, Douglas B.; Bradford, Carol R.; Carey, Thomas E.; Prince, Mark E. (2012). "UM‐SCC‐104: A New human papillomavirus‐16–positive cancer stem cell–containing head and neck squamous cell carcinoma cell line ." Head & Neck 34(10): 1480-1491. <http://hdl.handle.net/2027.42/93694>en_US
dc.identifier.issn1043-3074en_US
dc.identifier.issn1097-0347en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/93694
dc.description.abstractBackground Few human papillomavirus (HPV)(+) head and neck squamous cell carcinoma (HNSCC) cell lines exist. We established University of Michigan‐squamous cell carcinoma‐104 (UM‐SCC‐104), a new HPV(+) HNSCC cell line from a recurrent oral cavity tumor, and characterized it for the presence of cancer stem cells (CSCs). Methods Tumor cells were tested for biomarker expression by immunohistology, and the presence of HPV was assessed by several methods. Results UM‐SCC‐104 has a unique genotype, contains HPV‐16, and expresses E6/E7. Inoculation of aldehyde dehydrogenase (ALDH)(+) and ALDH(−) cells in an immunocompromised mouse resulted in tumor growth from the ALDH(+) cells after 6 weeks that recapitulated the histology of the primary, whereas ALDH(−) cells did not produce tumors. Conclusion UM‐SCC‐104, a new HPV‐16, CSC‐containing HNSCC cell line will aid in studying recurrent HPV(+) tumors. The aggressive nature of this tumor is consistent with high uniform expression of epidermal growth factor receptor (EGFR) and a functionally significant proportion of ALDH(+) CSCs. © 2011 Wiley Periodicals, Inc. Head Neck , 2011en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherHPVen_US
dc.subject.otherCancer Stem Cellsen_US
dc.subject.otherHead and Neck Cell Linesen_US
dc.subject.otherALDHen_US
dc.subject.otherHNSCCen_US
dc.titleUM‐SCC‐104: A New human papillomavirus‐16–positive cancer stem cell–containing head and neck squamous cell carcinoma cell lineen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOtolaryngologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Otolaryngology – Head & Neck Surgery, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumPre‐Doctoral Candidate Graduate Program in Cancer Biology, The University of Michigan School of Medicine, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Otolaryngology—Head & Neck Surgery, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherDepartment of Otolaryngology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jin Ju, South Koreaen_US
dc.contributor.affiliationotherVice President and Laboratory Director, aMDX Laboratory Sciences, Farmington Hills, Michiganen_US
dc.contributor.affiliationotherSequenom Molecular Medicine Laboratory, Ann Arbor, Michiganen_US
dc.identifier.pmid22162267en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/93694/1/21962_ftp.pdf
dc.identifier.doi10.1002/hed.21962en_US
dc.identifier.sourceHead & Necken_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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