Nano‐/microfiber scaffold for tissue engineering: Physical and biological properties
dc.contributor.author | Santana, Bianca Palma | en_US |
dc.contributor.author | dos Reis Paganotto, Gian Francesco | en_US |
dc.contributor.author | Nedel, Fernanda | en_US |
dc.contributor.author | Piva, Evandro | en_US |
dc.contributor.author | de Carvalho, Rodrigo Varella | en_US |
dc.contributor.author | Nör, Jacques Eduardo | en_US |
dc.contributor.author | Demarco, Flávio Fernando | en_US |
dc.contributor.author | Villarreal Carreño, Neftali Lenin | en_US |
dc.date.accessioned | 2012-10-02T17:20:30Z | |
dc.date.available | 2014-01-07T14:51:07Z | en_US |
dc.date.issued | 2012-11 | en_US |
dc.identifier.citation | Santana, Bianca Palma; dos Reis Paganotto, Gian Francesco; Nedel, Fernanda; Piva, Evandro; de Carvalho, Rodrigo Varella; Nör, Jacques Eduardo ; Demarco, Flávio Fernando ; Villarreal Carreño, Neftali Lenin (2012). "Nanoâ /microfiber scaffold for tissue engineering: Physical and biological properties ." Journal of Biomedical Materials Research Part A 100A(11): 3051-3058. <http://hdl.handle.net/2027.42/93772> | en_US |
dc.identifier.issn | 1549-3296 | en_US |
dc.identifier.issn | 1552-4965 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/93772 | |
dc.description.abstract | Alginate hydrogel (AH) has intrinsic physical and biological limitations that hinder its broader application in tissue engineering. We hypothesized that the inclusion of nanofibers in the hydrogel and the use of a biotemplate that mimics nature would enhance the translational potential of alginate hydrogels. In this study, we have shown a method to obtain nano‐/microfibers of titanium (nfTD) and hydroxyapatite (nfHY) using cotton as a biotemplate. These fibers were incorporated in the alginate hydrogel and the mechanical characteristics and biological response to these reinforced materials were evaluated. We observed that these nanofibers resembled the structure of natural collagen and did not mediate cell toxicity. The incorporation of nfTD or nfHY to the AH has not increased the viscosity of the hydrogel. Therefore, this is a feasible method to produce a scaffold with improved physical characteristics, while at the same time generating an enhanced environment for cell adhesion and proliferation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:3051–3058, 2012. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Alginate Hydrogel | en_US |
dc.subject.other | Hydroxyapatite | en_US |
dc.subject.other | Titanium | en_US |
dc.subject.other | Scaffolds | en_US |
dc.subject.other | Tissue Engineering | en_US |
dc.title | Nano‐/microfiber scaffold for tissue engineering: Physical and biological properties | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cardiology, Restorative Sciences, and Endodontics, of the University of Michigan School of Dentistry and the Department of Biomedical Engineering, University of Michigan College of Engineering in Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Operative Dentistry School of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil | en_US |
dc.contributor.affiliationother | Department of Operative Dentistry School of Dentistry, University of Paraná, Paraná, PR, Brazil | en_US |
dc.contributor.affiliationother | Technology Development Center, Federal University of Pelotas, Pelotas, RS, Brazil | en_US |
dc.contributor.affiliationother | Department of Operative Dentistry School of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/93772/1/34242_ftp.pdf | |
dc.identifier.doi | 10.1002/jbm.a.34242 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research Part A | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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