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Natural selection and the origin and maintenance of standard genetic marker systems

dc.contributor.authorLivingstone, Frank B.en_US
dc.date.accessioned2012-11-07T17:04:30Z
dc.date.available2012-11-07T17:04:30Z
dc.date.issued1980en_US
dc.identifier.citationLivingstone, Frank B. (1980). "Natural selection and the origin and maintenance of standard genetic marker systems." American Journal of Physical Anthropology 23(S1): 25-42. <http://hdl.handle.net/2027.42/94241>en_US
dc.identifier.issn0002-9483en_US
dc.identifier.issn1096-8644en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/94241
dc.description.abstractNatural selection has always been assumed to be the major force of evolution, but its presence has been difficult to demonstrate. A review of the evidence for selective differences among genotypes for most human genetic polymorphisms indicates there is little of a direct nature. Indirect theoretical evidence, however, seems to support a major role for natural selection, and it does not seem to support the hypothesis that most amino acid substitutions within the human species are neutral. Among small isolates, most of the gene frequency differences are most likely due to genetic drift or the founder effect, and the principal counterbalancing force is gene flow or migration. But genetic differences among the major human subdivisions do not seem to be due to the same interacting forces. One reason for the inability to detect selection has been an oversimplified view of its operation, which assigns genotypes a constant fitness in every generation. Many recent theoretical developments of more complicated kinds of selection may lead to a resolution of the problem and suggest better interpretations of the enormous amount of data on human genetic variation that is rapidly accumulating.en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherHuman Genetic Markersen_US
dc.subject.otherHuman Genetic Variationen_US
dc.subject.otherEvolutionary Theoryen_US
dc.subject.otherNeutral Mutationen_US
dc.subject.otherPolymorphismen_US
dc.subject.otherNatural Selectionen_US
dc.titleNatural selection and the origin and maintenance of standard genetic marker systemsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelAnthropologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Anthropology, The University of Michigan, Ann Arbor, Michigan 48109en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/94241/1/1330230504_ftp.pdf
dc.identifier.doi10.1002/ajpa.1330230504en_US
dc.identifier.sourceAmerican Journal of Physical Anthropologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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