Estradiol acts during a post‐pubertal sensitive period to shorten free‐running circadian period in male Octodon degus
dc.contributor.author | Hummer, Daniel L. | en_US |
dc.contributor.author | Peckham, Elizabeth M. | en_US |
dc.contributor.author | Lee, Theresa M. | en_US |
dc.date.accessioned | 2012-11-07T17:04:32Z | |
dc.date.available | 2013-11-15T16:44:23Z | en_US |
dc.date.issued | 2012-10 | en_US |
dc.identifier.citation | Hummer, Daniel L.; Peckham, Elizabeth M.; Lee, Theresa M. (2012). "Estradiol acts during a post‐pubertal sensitive period to shorten free‐running circadian period in male Octodon degus ." European Journal of Neuroscience 36(8). <http://hdl.handle.net/2027.42/94248> | en_US |
dc.identifier.issn | 0953-816X | en_US |
dc.identifier.issn | 1460-9568 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/94248 | |
dc.description.abstract | The free‐running circadian period is approximately 30 min shorter in adult male than in adult female Octodon degus . The sex difference emerges after puberty, resulting from a shortened free‐running circadian period in males. Castration before puberty prevents the emergence of the sex difference, but it is not a function of circulating gonadal hormones as such, because castration later in life does not affect free‐running circadian period. The aim of this study was to determine whether or not the shortening of the free‐running circadian period in male degus results from exposure to gonadal hormones after puberty. We hypothesized that masculinization of the circadian period results from an organizational effect of androgen exposure during a post‐pubertal sensitive period. Male degus were castrated before puberty and implanted with capsules filled with dihydrotestosterone (DHT), 17β‐estradiol (E2) or empty capsules at one of three ages: peri‐puberty (2–7 months), post‐puberty (7–12 months), or adulthood (14–19 months). Long‐term exposure to DHT or E2 did not result in a shortened free‐running circadian period when administered at 2–7 or 14–19 months of age. However, E2 treatment from 7 to 12 months of age decreased the free‐running circadian period in castrated males. This result was replicated in a subsequent experiment in which E2 treatment was limited to 8–12 months of age. E2 treatment at 7–12 months of age had no effect on the free‐running circadian period in ovariectomized females. Thus, there appears to be a post‐pubertal sensitive period for sexual differentiation of the circadian system of degus, during which E2 exposure decreases the free‐running circadian period in males. These data demonstrate that gonadal hormones can act during adolescent development to permanently alter the circadian system. The administration of estradiol during a sensitive period of post‐pubertal development decreases the free‐running circadian period of males but not females, resulting in a permanent sexual dimorphism in the circadian timekeeping mechanism of Octodon degus . These data demonstrate that gonadal hormones can act during adolescent development to permanently alter the circadian system. | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.subject.other | Adolescence | en_US |
dc.subject.other | SCN | en_US |
dc.subject.other | Sensitive Period | en_US |
dc.subject.other | Sexual Dimorphism | en_US |
dc.subject.other | Organizational Effects | en_US |
dc.title | Estradiol acts during a post‐pubertal sensitive period to shorten free‐running circadian period in male Octodon degus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Reproductive Sciences and Neuroscience Programs, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Psychology, Center for Behavioral Neuroscience, Morehouse College, 830 Westview Dr. SW, Atlanta, GA 30314, USA | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/94248/1/ejn8228.pdf | |
dc.identifier.doi | 10.1111/j.1460-9568.2012.08228.x | en_US |
dc.identifier.source | European Journal of Neuroscience | en_US |
dc.identifier.citedreference | Richards, M.P. ( 1966 ) Activity measured by running wheels and observation during the oestrous cycle, pregnancy and pseudopregnancy in the golden hamster. Anim. Behav., 14, 450 – 458. | en_US |
dc.identifier.citedreference | Nakamura, T.J., Shinohara, K., Funabashi, T. & Kimura, F. ( 2001 ) Effect of estrogen on the expression of Cry1 and Cry2 mRNAs in the suprachiasmatic nucleus of female rats. Neurosci. Res., 41, 251 – 255. | en_US |
dc.identifier.citedreference | Nakamura, T.J., Moriya, T., Inoue, S., Shimazoe, T., Watanabe, S., Ebihara, S. & Shinohara, K. ( 2005 ) Estrogen differentially regulates expression of Per1 and Per2 genes between central and peripheral clocks and between reproductive and nonreproductive tissues in female rats. J. Neurosci. Res., 82, 622 – 630. | en_US |
dc.identifier.citedreference | Nakamura, T.J., Sellix, M.T., Menaker, M. & Block, G.D. ( 2008 ) Estrogen directly modulates circadian rhythms of PER2 expression in the uterus. Am. J. Physiol. Endocrinol. Metab., 295, E1025 – E1031. | en_US |
dc.identifier.citedreference | Ovtscharoff, W. Jr & Braun, K. ( 2001 ) Maternal separation and social isolation modulate the postnatal development of synaptic composition in the infralimbic cortex of Octodon degus. Neuroscience, 104, 33 – 40. | en_US |
dc.identifier.citedreference | Pfaff, D. & Keiner, M. ( 1973 ) Atlas of estradiol‐concentrating cells in the central nervous system of the female rat. J. Comp. Neurol., 151, 121 – 158. | en_US |
dc.identifier.citedreference | Pittendrigh, C.S. & Daan, S. ( 1976 ) The stability and lability of spontaneous frequency. J. Comp. Physiol., 106, 223 – 252. | en_US |
dc.identifier.citedreference | Poeggel, G., Haase, C., Gulyaeva, N. & Braun, K. ( 2000 ) Quantitative changes in reduced nicotinamide adenine dinucleotide phosphate‐diaphorase‐reactive neurons in the brain of Octodon degus after periodic maternal separation and early social isolation. Neuroscience, 99, 381 – 387. | en_US |
dc.identifier.citedreference | Poeggel, G., Nowicki, L. & Braun, K. ( 2003 ) Early social deprivation alters monoaminergic afferents in the orbital prefrontal cortex of Octodon degus. Neuroscience, 116, 617 – 620. | en_US |
dc.identifier.citedreference | Poeggel, G., Nowicki, L. & Braun, K. ( 2005 ) Early social environment interferes with the development of NADPH‐diaphorase‐reactive neurons in the rodent orbital prefrontal cortex. J. Neurobiol., 62, 42 – 46. | en_US |
dc.identifier.citedreference | Primus, R.J. & Kellogg, C.K. ( 1990 ) Gonadal hormones during puberty organize environment‐related social interaction in the male rat. Horm. Behav., 24, 311 – 323. | en_US |
dc.identifier.citedreference | Roenneberg, T., Kuehnle, T., Pramstaller, P.P., Ricken, J., Havel, M., Guth, A. & Merrow, M. ( 2004 ) A marker for the end of adolescence. Curr. Biol., 14, R1038 – R1039. | en_US |
dc.identifier.citedreference | Schulz, K.M. & Sisk, C.L. ( 2006 ) Pubertal hormones, the adolescent brain, and the maturation of social behaviors: lessons from the Syrian hamster. Mol. Cell. Endocrinol., 254–255, 120 – 126. | en_US |
dc.identifier.citedreference | Schulz, K.M., Richardson, H.N., Zehr, J.L., Osetek, A.J., Menard, T.A. & Sisk, C.L. ( 2004 ) Gonadal hormones masculinize and defeminize reproductive behaviors during puberty in the male Syrian hamster. Horm. Behav., 45, 242 – 249. | en_US |
dc.identifier.citedreference | Schulz, K.M., Menard, T.A., Smith, D.A., Albers, H.E. & Sisk, C.L. ( 2006 ) Testicular hormone exposure during adolescence organizes flank‐marking behavior and vasopressin receptor binding in the lateral septum. Horm. Behav., 50, 477 – 483. | en_US |
dc.identifier.citedreference | Shinohara, K., Funabashi, T., Mitushima, D. & Kimura, F. ( 2000 ) Effects of estrogen on the expression of connexin32 and connexin43 mRNAs in the suprachiasmatic nucleus of female rats. Neurosci. Lett., 286, 107 – 110. | en_US |
dc.identifier.citedreference | Shinohara, K., Funabashi, T., Nakamura, T.J. & Kimura, F. ( 2001 ) Effects of estrogen and progesterone on the expression of connexin‐36 mRNA in the suprachiasmatic nucleus of female rats. Neurosci. Lett., 309, 37 – 40. | en_US |
dc.identifier.citedreference | Shughrue, P., Scrimo, P., Lane, M., Askew, R. & Merchenthaler, I. ( 1997a ) The distribution of estrogen receptor‐beta mRNA in forebrain regions of the estrogen receptor‐alpha knockout mouse. Endocrinology, 138, 5649 – 5652. | en_US |
dc.identifier.citedreference | Shughrue, P.J., Lane, M.V. & Merchenthaler, I. ( 1997b ) Comparative distribution of estrogen receptor‐alpha and ‐beta mRNA in the rat central nervous system. J. Comp. Neurol., 388, 507 – 525. | en_US |
dc.identifier.citedreference | Sibug, R.M., Stumpf, W.E., Shughrue, P.J., Hochberg, R.B. & Drews, U. ( 1991 ) Distribution of estrogen target sites in the 2‐day‐old mouse forebrain and pituitary gland during the ‘critical period’ of sexual differentiation. Brain Res. Dev. Brain Res., 61, 11 – 22. | en_US |
dc.identifier.citedreference | Su, J.D., Qiu, J., Zhong, Y.P. & Chen, Y.Z. ( 2001 ) Expression of estrogen receptor‐alpha and ‐beta immunoreactivity in the cultured neonatal suprachiasmatic nucleus: with special attention to GABAergic neurons. NeuroReport, 12, 1955 – 1959. | en_US |
dc.identifier.citedreference | Takahashi, J.S. & Menaker, M. ( 1980 ) Interaction of estradiol and progesterone: effects on circadian locomotor rhythm of female golden hamsters. Am. J. Physiol., 239, R497 – R504. | en_US |
dc.identifier.citedreference | Takamata, A., Torii, K., Miyake, K. & Morimoto, K. ( 2011 ) Chronic oestrogen replacement in ovariectomised rats attenuates food intake and augments c‐Fos expression in the suprachiasmatic nucleus specifically during the light phase. Br. J. Nutr., 106, 1283 – 1289. | en_US |
dc.identifier.citedreference | Vida, B., Hrabovszky, E., Kalamatianos, T., Coen, C.W., Liposits, Z. & Kallo, I. ( 2008 ) Oestrogen receptor alpha and beta immunoreactive cells in the suprachiasmatic nucleus of mice: distribution, sex differences and regulation by gonadal hormones. J. Neuroendocrinol., 20, 1270 – 1277. | en_US |
dc.identifier.citedreference | Zucker, I., Fitzgerald, K.M. & Morin, L.P. ( 1980 ) Sex differentiation of the circadian system in the golden hamster. Am. J. Physiol., 238, R97 – R101. | en_US |
dc.identifier.citedreference | Albers, H.E. ( 1981 ) Gonadal hormones organize and modulate the circadian system of the rat. Am. J. Physiol., 241, R62 – R66. | en_US |
dc.identifier.citedreference | Albers, H.E., Gerall, A.A. & Axelson, J.F. ( 1981 ) Effect of reproductive state on circadian periodicity in the rat. Physiol. Behav., 26, 21 – 25. | en_US |
dc.identifier.citedreference | Axelson, J.F., Gerall, A.A. & Albers, H.E. ( 1981 ) Effect of progesterone on the estrous activity cycle of the rat. Physiol. Behav., 26, 631 – 635. | en_US |
dc.identifier.citedreference | Cintra, A., Fuxe, K., Harfstrand, A., Agnati, L.F., Miller, L.S., Greene, J.L. & Gustafsson, J.‐A. ( 1986 ) On the cellular localization and distribution of estrogen receptors in the rat tel‐ and diencephalon using monoclonal antibodies to human estrogen receptor. Neurochem. Int., 8, 587 – 595. | en_US |
dc.identifier.citedreference | Conover, W.J. & Iman, R.L. ( 1981 ) Rank transformations as a bridge between parametric and nonparametric statistics. Am. Stat., 35, 124 – 129. | en_US |
dc.identifier.citedreference | Daan, S., Damassa, D., Pittendrigh, C.S. & Smith, E.R. ( 1975 ) An effect of castration and testosterone replacement on a circadian pacemaker in mice ( Mus musculus ). Proc. Natl. Acad. Sci. USA, 72, 3744 – 3747. | en_US |
dc.identifier.citedreference | Fatehi, M. & Fatehi‐Hassanabad, Z. ( 2008 ) Effects of 17beta‐estradiol on neuronal cell excitability and neurotransmission in the suprachiasmatic nucleus of rat. Neuropsychopharmacol., 33, 1354 – 1364. | en_US |
dc.identifier.citedreference | Gundlah, C., Kohama, S.G., Mirkes, S.J., Garyfallou, V.T., Urbanski, H.F. & Bethea, C.L. ( 2000 ) Distribution of estrogen receptor beta (ERbeta) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: continued expression with hormone replacement. Brain Res. Mol. Brain Res., 76, 191 – 204. | en_US |
dc.identifier.citedreference | Hagenauer, M.H., Ku, J.H. & Lee, T.M. ( 2011 ) Chronotype changes during puberty depend on gonadal hormones in the slow‐developing rodent, Octodon degus. Horm. Behav., 60, 37 – 45. | en_US |
dc.identifier.citedreference | Helmeke, C., Ovtscharoff, W. Jr, Poeggel, G. & Braun, K. ( 2001a ) Juvenile emotional experience alters synaptic inputs on pyramidal neurons in the anterior cingulate cortex. Cereb. Cortex, 11, 717 – 727. | en_US |
dc.identifier.citedreference | Helmeke, C., Poeggel, G. & Braun, K. ( 2001b ) Differential emotional experience induces elevated spine densities on basal dendrites of pyramidal neurons in the anterior cingulate cortex of Octodon degus. Neuroscience, 104, 927 – 931. | en_US |
dc.identifier.citedreference | Hier, D.B. & Crowley, W.F. Jr ( 1982 ) Spatial ability in androgen‐deficient men. N. Engl. J. Med., 306, 1202 – 1205. | en_US |
dc.identifier.citedreference | Hileman, S.M., Handa, R.J. & Jackson, G.L. ( 1999 ) Distribution of estrogen receptor‐beta messenger ribonucleic acid in the male sheep hypothalamus. Biol. Reprod., 60, 1279 – 1284. | en_US |
dc.identifier.citedreference | Hummer, D.L., Jechura, T.J., Mahoney, M.M. & Lee, T.M. ( 2007 ) Gonadal hormone effects on entrained and free‐running circadian activity rhythms in the developing diurnal rodent Octodon degus. Am. J. Physiol. Regul. Integr. Comp. Physiol., 292, R586 – R597. | en_US |
dc.identifier.citedreference | Iwahana, E., Karatsoreos, I., Shibata, S. & Silver, R. ( 2008 ) Gonadectomy reveals sex differences in circadian rhythms and suprachiasmatic nucleus androgen receptors in mice. Horm. Behav., 53, 422 – 430. | en_US |
dc.identifier.citedreference | Jechura, T.J., Walsh, J.M. & Lee, T.M. ( 2000 ) Testicular hormones modulate circadian rhythms of the diurnal rodent, Octodon degus. Horm. Behav., 38, 243 – 249. | en_US |
dc.identifier.citedreference | Karatsoreos, I.N. & Silver, R. ( 2007 ) The neuroendocrinology of the suprachiasmatic nucleus as a conductor of body time in mammals. Endocrinology, 148, 5640 – 5647. | en_US |
dc.identifier.citedreference | Karatsoreos, I.N., Wang, A., Sasanian, J. & Silver, R. ( 2007 ) A role for androgens in regulating circadian behavior and the suprachiasmatic nucleus. Endocrinology, 148, 5487 – 5495. | en_US |
dc.identifier.citedreference | Kriegsfeld, L.J. & Silver, R. ( 2006 ) The regulation of neuroendocrine function: timing is everything. Horm. Behav., 49, 557 – 574. | en_US |
dc.identifier.citedreference | Kruijver, F.P. & Swaab, D.F. ( 2002 ) Sex hormone receptors are present in the human suprachiasmatic nucleus. Neuroendocrinology, 75, 296 – 305. | en_US |
dc.identifier.citedreference | Labyak, S.E. & Lee, T.M. ( 1995 ) Estrus‐ and steroid‐induced changes in circadian rhythms in a diurnal rodent, Octodon degus. Physiol. Behav., 58, 573 – 585. | en_US |
dc.identifier.citedreference | Lee, T.M. & Labyak, S.E. ( 1997 ) Free‐running rhythms and light‐ and dark‐pulse phase response curves for diurnal Octodon degus (Rodentia). Am. J. Physiol., 273, R278 – R286. | en_US |
dc.identifier.citedreference | Mahoney, M.M., Ramanathan, C., Hagenauer, M.H., Thompson, R.C., Smale, L. & Lee, T. ( 2009 ) Daily rhythms and sex differences in vasoactive intestinal polypeptide, VIPR2 receptor and arginine vasopressin mRNA in the suprachiasmatic nucleus of a diurnal rodent, Arvicanthis niloticus. Eur. J. Neurosci., 30, 1537 – 1543. | en_US |
dc.identifier.citedreference | Mahoney, M.M., Rossi, B.V., Hagenauer, M.H. & Lee, T.M. ( 2011 ) Characterization of the estrous cycle in Octodon degus. Biol. Reprod., 84, 664 – 671. | en_US |
dc.identifier.citedreference | Mitra, S.W., Hoskin, E., Yudkovitz, J., Pear, L., Wilkinson, H.A., Hayashi, S., Pfaff, D.W., Ogawa, S., Rohrer, S.P., Schaeffer, J.M., McEwen, B.S. & Alves, S.E. ( 2003 ) Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha. Endocrinology, 144, 2055 – 2067. | en_US |
dc.identifier.citedreference | Morin, L.P., Fitzgerald, K.M. & Zucker, I. ( 1977 ) Estradiol shortens the period of hamster circadian rhythms. Science, 196, 305 – 307. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.