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Changes in Notch signaling coordinates maintenance and differentiation of the Drosophila larval optic lobe neuroepithelia

dc.contributor.authorWeng, Moen_US
dc.contributor.authorHaenfler, Jill M.en_US
dc.contributor.authorLee, Cheng‐yuen_US
dc.date.accessioned2012-11-07T17:04:38Z
dc.date.available2014-01-07T14:51:08Zen_US
dc.date.issued2012-11en_US
dc.identifier.citationWeng, Mo; Haenfler, Jill M.; Lee, Cheng‐yu (2012). "Changes in Notch signaling coordinates maintenance and differentiation of the Drosophila larval optic lobe neuroepithelia." Developmental Neurobiology 72(11): 1376-1390. <http://hdl.handle.net/2027.42/94272>en_US
dc.identifier.issn1932-8451en_US
dc.identifier.issn1932-846Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/94272
dc.description.abstractA dynamic balance between stem cell maintenance and differentiation paces generation of post‐mitotic progeny during normal development and maintenance of homeostasis. Recent studies show that Notch plays a key role in regulating the identity of neuroepithelial stem cells, which generate terminally differentiated neurons that populate the adult optic lobe via the intermediate progenitor cell type called neuroblast. Thus, understanding how Notch controls neuroepithelial cell maintenance and neuroblast formation will provide critical insight into the intricate regulation of stem cell function during tissue morphogenesis. Here, we showed that a low level of Notch signaling functions to maintain the neuroepithelial cell identity by suppressing the expression of pointedP1 gene through the transcriptional repressor Anterior open. Increased Notch signaling, which coincides with transient cell cycle arrest but precedes the expression of PointedP1 in cells near the medial edge of neuroepithelia, defines transitioning neuroepithelial cells that are in the process of acquiring the neuroblast identity. Transient up‐regulation of Notch signaling in transitioning neuroepithelial cells decreases their sensitivity to PointedP1 and prevents them from becoming converted into neuroblasts prematurely. Down‐regulation of Notch signaling combined with a high level of PointedP1 trigger a synchronous conversion from transitioning neuroepithelial cells to immature neuroblasts at the medial edge of neuroepithelia. Thus, changes in Notch signaling orchestrate a dynamic balance between maintenance and conversion of neuroepithelial cells during optic lobe neurogenesis. © 2011 Wiley Periodicals, Inc. Develop Neurobiol, 2012en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherPointedP1en_US
dc.subject.otherNeuroepitheliaen_US
dc.subject.otherNeuroblasten_US
dc.subject.otherOptic Lobeen_US
dc.subject.otherNotchen_US
dc.titleChanges in Notch signaling coordinates maintenance and differentiation of the Drosophila larval optic lobe neuroepitheliaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumProgram in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDivision of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumCenter for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationotherDepartment of Molecular Biology, Howard Hughes Medical Institute, Princeton University, NJ 08544en_US
dc.identifier.pmid22038743en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/94272/1/20995_ftp.pdf
dc.identifier.doi10.1002/dneu.20995en_US
dc.identifier.sourceDevelopmental Neurobiologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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