Delayed graft function requiring more than one‐time dialysis treatment is associated with inferior clinical outcomes
dc.contributor.author | Jayaram, Deepa | en_US |
dc.contributor.author | Kommareddi, Mallika | en_US |
dc.contributor.author | Sung, Randall S. | en_US |
dc.contributor.author | Luan, Fu L. | en_US |
dc.date.accessioned | 2012-11-07T17:04:40Z | |
dc.date.available | 2013-10-18T17:47:29Z | en_US |
dc.date.issued | 2012-09 | en_US |
dc.identifier.citation | Jayaram, Deepa; Kommareddi, Mallika; Sung, Randall S.; Luan, Fu L. (2012). "Delayed graft function requiring more than one‐time dialysis treatment is associated with inferior clinical outcomes." Clinical Transplantation (5): E536-E543. <http://hdl.handle.net/2027.42/94277> | en_US |
dc.identifier.issn | 0902-0063 | en_US |
dc.identifier.issn | 1399-0012 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/94277 | |
dc.description.abstract | Delayed graft function ( DGF ) is a common complication of deceased donor kidney transplantation with negative impact on clinical outcomes. In a single‐center retrospective analysis, we compared patient and kidney survival, early renal function, and the incidence of acute rejection during the first year among all adult deceased donor kidney transplant patients without DGF , with DGF requiring one‐time and/or more than one‐time dialysis treatment between January 1, 2000, and D ecember 31, 2008. Of 831 adult kidney transplant patients, 74 (8.9%) required one‐time and 134 (16.1%) more than one‐time dialysis treatment post‐transplantation, respectively. While DGF patients with one‐time dialysis treatment had comparable clinical outcomes to that of patients without DGF , patients with DGF requiring more than one‐time dialysis treatment had a 45% increased risk for death ( HR 1.45, 95% CI 1.02, 2.05, p = 0.04) after adjustment for the differences in demographic and baseline characteristics. Furthermore, DGF patients with more than one‐time dialysis requirement displayed significantly lower renal function after recovery ( OR 0.32, 95% CI 0.21, 0.49, p < 0.001, for e GFR ≥ 60 mL/min) and higher incidence of acute rejection during the first year ( OR 1.66, 95% CI 1.11, 2.49, p = 0.015). Additional studies of therapeutic approaches to manage patients with prolonged DGF are needed. | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.subject.other | Dialysis Requirement | en_US |
dc.subject.other | Kidney Transplantation | en_US |
dc.subject.other | Mortality Risk | en_US |
dc.subject.other | Renal Function | en_US |
dc.subject.other | Delayed Graft Function | en_US |
dc.subject.other | Acute Rejection | en_US |
dc.title | Delayed graft function requiring more than one‐time dialysis treatment is associated with inferior clinical outcomes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 23061763 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/94277/1/ctr12029.pdf | |
dc.identifier.doi | 10.1111/ctr.12029 | en_US |
dc.identifier.source | Clinical Transplantation | en_US |
dc.identifier.citedreference | Sung RS, Guidinger MK, Lake CD et al. Impact of the expanded criteria donor allocation system on the use of expanded criteria donor kidneys. Transplantation 2005: 79: 1257. | en_US |
dc.identifier.citedreference | Ojo AO, Wolfe RA, Held PJ, Port FK, Schmouder RL. Delayed graft function: risk factors and implications for renal allograft survival. Transplantation 1997: 63: 968. | en_US |
dc.identifier.citedreference | Perico N, Cattaneo D, Sayegh MH, Remuzzi G. Delayed graft function in kidney transplantation. Lancet 2004: 364: 1814. | en_US |
dc.identifier.citedreference | Sellers MT, Gallichio MH, Hudson SL et al. Improved outcomes in cadaveric renal allografts with pulsatile preservation. Clin Transplant 2000: 14: 543. | en_US |
dc.identifier.citedreference | Tapiawala SN, Tinckam KJ, Cardella CJ et al. Delayed graft function and the risk for death with a functioning graft. J Am Soc Nephrol 2010: 21: 153. | en_US |
dc.identifier.citedreference | Yarlagadda SG, Coca SG, Garg AX et al. Marked variation in the definition and diagnosis of delayed graft function: a systematic review. Nephrol Dial Transplant 2008: 23: 2995. | en_US |
dc.identifier.citedreference | Yarlagadda SG, Coca SG, Formica RN Jr, Poggio ED, Parikh CR. Association between delayed graft function and allograft and patient survival: a systematic review and meta‐analysis. Nephrol Dial Transplant 2009: 24: 1039. | en_US |
dc.identifier.citedreference | Yokoyama I, Uchida K, Kobayashi T, Tominaga Y, Orihara A, Takagi H. Effect of prolonged delayed graft function on long‐term graft outcome in cadaveric kidney transplantation. Clin Transplant 1994: 8 ( Pt 1 ): 101. | en_US |
dc.identifier.citedreference | Humar A, Ramcharan T, Kandaswamy R, Gillingham K, Payne WD, Matas AJ. Risk factors for slow graft function after kidney transplants: a multivariate analysis. Clin Transplant 2002: 16: 425. | en_US |
dc.identifier.citedreference | Dominguez J, Lira F, Rebolledo R et al. Duration of delayed graft function is an important predictor of 1‐year serum creatinine. Transplant Proc 2009: 41: 131. | en_US |
dc.identifier.citedreference | Giral‐Classe M, Hourmant M, Cantarovich D et al. Delayed graft function of more than six days strongly decreases long‐term survival of transplanted kidneys. Kidney Int 1998: 54: 972. | en_US |
dc.identifier.citedreference | Troppmann C, Gillingham KJ, Benedetti E et al. Delayed graft function, acute rejection, and outcome after cadaver renal transplantation. The multivariate analysis. Transplantation 1995: 59: 962. | en_US |
dc.identifier.citedreference | Akkina SK, Connaire JJ, Israni AK, Snyder JJ, Matas AJ, Kasiske BL. Similar outcomes with different rates of delayed graft function may reflect center practice, not center performance. Am J Transplant 2009: 9: 1460. | en_US |
dc.identifier.citedreference | Dickinson DM, Ellison MD, Webb RL. Data sources and structure. Am J Transplant 2003: 3 ( Suppl 4 ): 13. | en_US |
dc.identifier.citedreference | Heldal K, Hartmann A, Leivestad T et al. Clinical outcomes in elderly kidney transplant recipients are related to acute rejection episodes rather than pretransplant comorbidity. Transplantation 2009: 87: 1045. | en_US |
dc.identifier.citedreference | Whiting JF, Delmonico F, Morrissey P et al. Clinical results of an organ procurement organization effort to increase utilization of donors after cardiac death. Transplantation 2006: 81: 1368. | en_US |
dc.identifier.citedreference | Merion RM, Ashby VB, Wolfe RA et al. Deceased‐donor characteristics and the survival benefit of kidney transplantation. JAMA 2005: 294: 2726. | en_US |
dc.identifier.citedreference | Locke JE, Segev DL, Warren DS, Dominici F, Simpkins CE, Montgomery RA. Outcomes of kidneys from donors after cardiac death: implications for allocation and preservation. Am J Transplant 2007: 7: 1797. | en_US |
dc.identifier.citedreference | Saidi RF, Elias N, Kawai T et al. Outcome of kidney transplantation using expanded criteria donors and donation after cardiac death kidneys: realities and costs. Am J Transplant 2007: 7: 2769. | en_US |
dc.identifier.citedreference | Moers C, Smits JM, Maathuis MH et al. Machine perfusion or cold storage in deceased‐donor kidney transplantation. N Engl J Med 2009: 360: 7. | en_US |
dc.identifier.citedreference | Perez Fontan M, Rodriquez‐Carmona A, Bouza P et al. Outcome of grafts with long‐lasting delayed function after renal transplantation. Transplantation 1996: 62: 42. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.