Wrapping and dispersion of multiwalled carbon nanotubes improves electrical conductivity of protein–nanotube composite biomaterials
dc.contributor.author | Voge, Christopher M. | en_US |
dc.contributor.author | Johns, Jeremy | en_US |
dc.contributor.author | Raghavan, Mekhala | en_US |
dc.contributor.author | Morris, Michael D. | en_US |
dc.contributor.author | Stegemann, Jan P. | en_US |
dc.date.accessioned | 2012-12-11T17:37:36Z | |
dc.date.available | 2014-03-03T15:09:25Z | en_US |
dc.date.issued | 2013-01 | en_US |
dc.identifier.citation | Voge, Christopher M.; Johns, Jeremy; Raghavan, Mekhala; Morris, Michael D.; Stegemann, Jan P. (2013). "Wrapping and dispersion of multiwalled carbon nanotubes improves electrical conductivity of protein–nanotube composite biomaterials ." Journal of Biomedical Materials Research Part A 101A(1): 231-238. <http://hdl.handle.net/2027.42/94526> | en_US |
dc.identifier.issn | 1549-3296 | en_US |
dc.identifier.issn | 1552-4965 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/94526 | |
dc.description.abstract | Composites of extracellular matrix proteins reinforced with carbon nanotubes have the potential to be used as conductive biopolymers in a variety of biomaterial applications. In this study, the effect of functionalization and polymer wrapping on the dispersion of multiwalled carbon nanotubes (MWCNT) in aqueous media was examined. Carboxylated MWCNT were wrapped in either Pluronic ® F127 or gelatin. Raman spectroscopy and X‐ray photoelectron spectroscopy showed that covalent functionalization of the pristine nanotubes disrupted the carbon lattice and added carboxyl groups. Polymer and gelatin wrapping resulted in increased surface adsorbed oxygen and nitrogen, respectively. Wrapping also markedly increased the stability of MWCNT suspensions in water as measured by settling time and zeta potential, with Pluronic ® ‐wrapped nanotubes showing the greatest effect. Treated MWCNT were used to make 3D collagen–fibrin–MWCNT composite materials. Carboxylated MWCNT resulted in a decrease in construct impedance by an order of magnitude, and wrapping with Pluronic ® resulted in a further order of magnitude decrease. Functionalization and wrapping also were associated with maintenance of fibroblast function within protein–MWCNT materials. These data show that increased dispersion of nanotubes in protein–MWCNT composites leads to higher conductivity and improved cytocompatibility. Understanding how nanotubes interact with biological systems is important in enabling the development of new biomedical technologies. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A:231–238, 2013. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Carbon Nanotubes | en_US |
dc.subject.other | Collagen | en_US |
dc.subject.other | Fibroblast | en_US |
dc.subject.other | Nanoparticle | en_US |
dc.subject.other | Pluronic | en_US |
dc.subject.other | Composite | en_US |
dc.title | Wrapping and dispersion of multiwalled carbon nanotubes improves electrical conductivity of protein–nanotube composite biomaterials | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineering, University of Michigan, Ann Arbor, 1101 Beal Ave., Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineering, University of Michigan, Ann Arbor, 1101 Beal Ave., Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, 930 N. University Ave., Ann Arbor, Michigan 48108 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/94526/1/34310_ftp.pdf | |
dc.identifier.doi | 10.1002/jbm.a.34310 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research Part A | en_US |
dc.identifier.citedreference | George JJ, Sengupta R, Bhowmick AK. Influence of functionalization of multi‐walled carbon nanotubes on the properties of ethylene vinyl acetate nanocomposites. J Nanosci Nanotechnol 2008; 8: 1913 – 1921. | en_US |
dc.identifier.citedreference | Keefer EW, Botterman BR, Romero MI, Rossi AF, Gross GW. Carbon nanotube coating improves neuronal recordings. Nat Nano 2008; 3: 434 – 439. | en_US |
dc.identifier.citedreference | MacDonald RA, Voge CM, Kariolis M, Stegemann JP. Carbon nanotubes increase the electrical conductivity of fibroblast‐seeded collagen hydrogels. Acta Biomater 2008; 4: 1583 – 1592. | en_US |
dc.identifier.citedreference | Voge CM, Kariolis M, MacDonald RA, Stegemann JP. Directional conductivity in SWNT‐collagen‐fibrin composite biomaterials through strain‐induced matrix alignment. J Biomed Mater Res A 2008; 86: 269 – 277. | en_US |
dc.identifier.citedreference | Banerjee S, Hemraj‐Benny T, Wong SS. Covalent surface chemistry of single‐walled carbon nanotubes. Adv Mater 2005; 17: 17 – 29. | en_US |
dc.identifier.citedreference | Peng H, Alemany LB, Margrave JL, Khabashesku VN. Sidewall carboxylic acid functionalization of single‐walled carbon nanotubes. J Am Chem Soc 2003; 125: 15174 – 15182. | en_US |
dc.identifier.citedreference | Zhang J, Zou H, Qing Q, Yang Y, Li Q, Liu Z, Guo X, Du Z. Effect of chemical oxidation on the structure of single‐walled carbon nanotubes. J Phys Chem B 2003; 107: 3712 – 3718. | en_US |
dc.identifier.citedreference | Moore VC, Strano MS, Haroz EH, Hauge RH, Smalley RE. Individually suspended single‐walled carbon nanotubes in various surfactants. Nano Lett 2003; 3: 1379 – 1382. | en_US |
dc.identifier.citedreference | Wenseleers W, Vlasov II, Goovaerts E, Obraztsova ED, Lobach AS, Bouwen A. Efficient isolation and solubilization of pristine single‐walled nanotubes in bile salt micelles. Adv Funct Mater 2004; 14: 1105 – 1112. | en_US |
dc.identifier.citedreference | Ciofani G, Raffa V, Pensabene V, Menciassi A, Dario P. Dispersion of multi‐walled carbon nanotubes in aqueous pluronic F127 solutions for biological applications. Fuller Nanotub Car N 2009; 17: 11. | en_US |
dc.identifier.citedreference | Nativ‐Roth E, Shvartzman‐Cohen R, Bounioux C, Florent M, Zhang D, Szleifer I, Yerushalmi‐Rozen R. Physical adsorption of block copolymers to SWNT and MWNT: A nonwrapping mechanism. Macromolecules 2007; 40: 3676 – 3685. | en_US |
dc.identifier.citedreference | Schmolka IR. Artificial skin I. Preparation and properties of pluronic F‐127 gels for treatment of burns. J Biomed Mater Res 1972; 6: 571 – 582. | en_US |
dc.identifier.citedreference | Dresselhaus MS, Dresselhaus G, Saito R, Jorio A. Raman spectroscopy of carbon nanotubes. Phys Reports 2005; 409: 47 – 99. | en_US |
dc.identifier.citedreference | Hiura H. Raman studies of carbon nanotubes. Chem Phys Lett 1993; 202: 509 – 512. | en_US |
dc.identifier.citedreference | Behler K, Osswald S, Ye H, Dimovski S, Gogotsi Y. Effect of thermal treatment on the structure of multi‐walled carbon nanotubes. J Nanopart Res 2006; 8: 615 – 625. | en_US |
dc.identifier.citedreference | Sinani VA, Gheith MK, Yaroslavov AA, Rakhnyanskaya AA, Sun K, Mamedov AA, Wicksted JP, Kotov NA. Aqueous dispersions of single‐wall and multiwall carbon nanotubes with designed amphiphilic polycations. JACS 2005; 127: 3463 – 3472. | en_US |
dc.identifier.citedreference | Hu H, Yu A, Kim E, Zhao B, Itkis ME, Bekyarova E, Haddon RC. Influence of the zeta potential on the dispersability and purification of single‐walled carbon nanotubes. J Phys Chem B 2005; 109: 11520 – 11524. | en_US |
dc.identifier.citedreference | Magnusson G, Olsson T, Nyberg J‐A. Toxicity of pluronic F‐68. Toxicol Lett 1986; 30: 203 – 207. | en_US |
dc.identifier.citedreference | Bardi G, Tognini P, Ciofani G, Raffa V, Costa M, Pizzorusso T. Pluronic‐coated carbon nanotubes do not induce degeneration of cortical neurons in vivo and in vitro. Nanomed Nanotechnol 2009; 5: 96 – 104. | en_US |
dc.identifier.citedreference | Musumeci AW, Silva GG, Liu J‐W, Martens WN, Waclawik ER. Structure and conductivity of multi‐walled carbon nanotube/poly(3‐hexylthiophene) composite films. Polymer 2007; 48: 1667 – 1678. | en_US |
dc.identifier.citedreference | Sandler JKW, Kirk JE, Kinloch IA, Shaffer MSP, Windle AH. Ultra‐low electrical percolation threshold in carbon‐nanotube‐epoxy composites. Polymer 2003; 44: 5893 – 5899. | en_US |
dc.identifier.citedreference | Li J, Ma PC, Chow WS, To CK, Tang BZ, Kim J‐K. Correlations between percolation threshold, dispersion state and aspect ratio of carbon nanotubes. Adv Funct Mater 2007; 17: 3207 – 3215. | en_US |
dc.identifier.citedreference | Quent VMC, Loessner D, Friis T, Reichert JC, Hutmacher DW. Discrepancies between metabolic activity and DNA content as tool to assess cell proliferation in cancer research. J Cell Mol Med 2010; 14: 1003 – 1013. | en_US |
dc.identifier.citedreference | Wörle‐Knirsch JM, Pulskamp K, Krug HF. Oops they did it again! Carbon nanotubes hoax scientists in viability assays. Nano Lett 2006; 6: 1261 – 1268. | en_US |
dc.identifier.citedreference | Wick P, Manser P, Limbach LK, Dettlaff‐Weglikowska U, Krumeich F, Roth S, Stark WJ, Bruinink A. The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol Lett 2007; 168: 121 – 131. | en_US |
dc.identifier.citedreference | Nimmagadda A, Thurston K, Nollert MU, McFetridge PS. Chemical modification of SWNT alters in vitro cell‐SWNT interactions. J Biomed Mater Res A 2006; 76: 614 – 625. | en_US |
dc.identifier.citedreference | Belyanskaya L, Weigel S, Hirsch C, Tobler U, Krug HF, Wick P. Effects of carbon nanotubes on primary neurons and glial cells. NeuroToxicology 2009; 30: 702 – 711. | en_US |
dc.identifier.citedreference | Farokhzad OC, Langer R. Impact of nanotechnology on drug delivery. ACS Nano 2009; 3: 16 – 20. | en_US |
dc.identifier.citedreference | Martin CR, Kohli P. The emerging field of nanotube biotechnology. Nat Rev Drug Discov 2003; 2: 29 – 37. | en_US |
dc.identifier.citedreference | Moniruzzaman M, Winey KI. Polymer nanocomposites containing carbon nanotubes. Macromolecules 2006; 39: 5194 – 5205. | en_US |
dc.identifier.citedreference | Coleman JN, Khan U, Gun'ko YK. Mechanical reinforcement of polymers using carbon nanotubes. Adv Mater 2006; 18: 689 – 706. | en_US |
dc.identifier.citedreference | Luo SC, Xie H, Chen N, Yu H‐hua. Trinity DNA detection platform by ultrasmooth and functionalized PEDOT biointerfaces. ACS App Mater Inf 2009; 1: 1414 – 1419. | en_US |
dc.identifier.citedreference | Dong H, Cao X, Li CM. Functionalized polypyrrole film: Synthesis, characterization and potential applications in chemical and biological sensors. ACS App Mater Inf 2009; 1: 1599 – 1606. | en_US |
dc.identifier.citedreference | Sangodkar H, Sukeerthi S, Srinivasa RS, Lal R, Contractor AQ. A biosensor array based on polyaniline. Anal Chem 1996; 68: 779 – 783. | en_US |
dc.identifier.citedreference | MacDonald RA, Laurenzi BF, Viswanathan G, Ajayan PM, Stegemann JP. Collagen‐carbon nanotube composite materials as scaffolds in tissue engineering. J Biomed Mater Res A 2005; 74: 489 – 496. | en_US |
dc.identifier.citedreference | Crouzier T, Nimmagadda A, Nollert MU, McFetridge PS. Modification of single walled carbon nanotube surface chemistry to improve aqueous solubility and enhance cellular interactions. Langmuir 2008; 24: 13173 – 13181. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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