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Concise Review: The Evolution of human pluripotent stem cell culture: From feeder cells to synthetic coatings
dc.contributor.authorVilla‐diaz, L.g.en_US
dc.contributor.authorRoss, A.M.en_US
dc.contributor.authorLahann, J.en_US
dc.contributor.authorKrebsbach, P.H.en_US
dc.date.accessioned2013-01-03T19:35:38Z
dc.date.available2014-03-03T15:09:23Zen_US
dc.date.issued2013-01en_US
dc.identifier.citationVilla‐diaz, L.g. ; Ross, A.M.; Lahann, J.; Krebsbach, P.H. (2013). "Concise Review: The Evolution of human pluripotent stem cell culture: From feeder cells to synthetic coatings ." STEM CELLS 31(1): 1-7. <http://hdl.handle.net/2027.42/94687>en_US
dc.identifier.issn1066-5099en_US
dc.identifier.issn1549-4918en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/94687
dc.description.abstractCurrent practices to maintain human pluripotent stem cells (hPSCs), which include induced pluripotent stem cells and embryonic stem cells, in an undifferentiated state typically depend on the support of feeder cells such as mouse embryonic fibroblasts (MEFs) or an extracellular matrix such as Matrigel. Culture conditions that depend on these undefined support systems limit our ability to interpret mechanistic studies aimed at resolving how hPSCs interact with their extracellular environment to remain in a unique undifferentiated state and to make fate‐changing lineage decisions. Likewise, the xenogeneic components of MEFs and Matrigel ultimately hinder our ability to use pluripotent stem cells to treat debilitating human diseases. Many of these obstacles have been overcome by the development of synthetic coatings and bioreactors that support hPSC expansion and self‐renewal within defined culture conditions that are free from xenogeneic contamination. The establishment of defined culture conditions and synthetic matrices will facilitate studies to more precisely probe the molecular basis of pluripotent stem cell self‐renewal and differentiation. When combined with three‐dimensional cultures in bioreactors, these systems will also enable large‐scale expansion for future clinical applications. S TEM C ells 2013;31:1–7en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherHuman Embryonic Stem Cellsen_US
dc.subject.otherPolymer Coatingsen_US
dc.subject.otherSelf‐Renewalen_US
dc.subject.otherDifferentiationen_US
dc.subject.otherPluripotent Stem Cellsen_US
dc.subject.otherInduced Pluripotent Stem Cellsen_US
dc.titleConcise Review: The Evolution of human pluripotent stem cell culture: From feeder cells to synthetic coatingsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Ave, Ann Arbor, Michigan 48109‐1078, USAen_US
dc.contributor.affiliationumDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationotherDepartment of Biologic & Materials Sciences, School of Dentistryen_US
dc.contributor.affiliationotherDepartment of Chemical Engineeringen_US
dc.identifier.pmid23081828en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/94687/1/1260_ftp.pdf
dc.identifier.doi10.1002/stem.1260en_US
dc.identifier.sourceSTEM CELLSen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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