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Antimicrobial polymers as synthetic mimics of host‐defense peptides
dc.contributor.authorKuroda, Kenichien_US
dc.contributor.authorCaputo, Gregory A.en_US
dc.date.accessioned2013-01-03T19:38:28Z
dc.date.available2014-03-03T15:09:24Zen_US
dc.date.issued2013-01en_US
dc.identifier.citationKuroda, Kenichi; Caputo, Gregory A. (2013). "Antimicrobial polymers as synthetic mimics of host‐defense peptides." Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 5(1): 49-66. <http://hdl.handle.net/2027.42/94848>en_US
dc.identifier.issn1939-5116en_US
dc.identifier.issn1939-0041en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/94848
dc.description.abstractAntibiotic‐resistant bacteria ‘superbugs’ are an emerging threat to public health due to the decrease in effective antibiotics as well as the slowed pace of development of new antibiotics to replace those that become ineffective. The need for new antimicrobial agents is a well‐documented issue relating to world health. Tremendous efforts have been given to developing compounds that not only show high efficacy, but also those that are less susceptible to resistance development in the bacteria. However, the development of newer, stronger antibiotics which can overcome these acquired resistances is still a scientific challenge because a new mode of antimicrobial action is likely required. To that end, amphiphilic, cationic polymers have emerged as a promising candidate for further development as an antimicrobial agent with decreased potential for resistance development. These polymers are designed to mimic naturally occurring host‐defense antimicrobial peptides which act on bacterial cell walls or membranes. Antimicrobial‐peptide mimetic polymers display antibacterial activity against a broad spectrum of bacteria including drug‐resistant strains and are less susceptible to resistance development in bacteria. These polymers also showed selective activity to bacteria over mammalian cells. Antimicrobial polymers provide a new molecular framework for chemical modification and adaptation to tune their biological functions. The peptide‐mimetic design of antimicrobial polymers will be versatile, generating a new generation of antibiotics toward implementation of polymers in biomedical applications. WIREs Nanomed Nanobiotechnol 2013, 5:49–66. doi: 10.1002/wnan.1199 Conflict of interest: K. K. is a coinventor on a patent application filed by the University of Pennsylvania covering ‘Antimicrobial Copolymers and Uses Thereof’. The patent application has been licensed to PolyMedix Inc. (Radnor, PA). PolyMedix did not play a role in the design and conduct of this study; in the collection, analysis, or interpretation of the data; or in the preparation, review, or approval of the article. For further resources related to this article, please visit the WIREs website .en_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.titleAntimicrobial polymers as synthetic mimics of host‐defense peptidesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiomedical Engineeringen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherDepartment of Chemistry and Biochemistry, Rowan University, Glassboro, NJ, USAen_US
dc.contributor.affiliationotherDepartment of Chemistry and Biochemistry, Rowan University, Glassboro, NJ, USAen_US
dc.identifier.pmid23076870en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/94848/1/1199_ftp.pdf
dc.identifier.doi10.1002/wnan.1199en_US
dc.identifier.sourceWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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