Heterogeneity of tibial plateau cartilage in response to a physiological compressive strain rate
dc.contributor.author | Deneweth, Jessica M. | en_US |
dc.contributor.author | Newman, Kelly E. | en_US |
dc.contributor.author | Sylvia, Stephen M. | en_US |
dc.contributor.author | McLean, Scott G. | en_US |
dc.contributor.author | Arruda, Ellen M. | en_US |
dc.date.accessioned | 2013-02-12T19:00:22Z | |
dc.date.available | 2014-05-01T14:28:18Z | en_US |
dc.date.issued | 2013-03 | en_US |
dc.identifier.citation | Deneweth, Jessica M.; Newman, Kelly E.; Sylvia, Stephen M.; McLean, Scott G.; Arruda, Ellen M. (2013). "Heterogeneity of tibial plateau cartilage in response to a physiological compressive strain rate ." Journal of Orthopaedic Research 31(3): 370-375. <http://hdl.handle.net/2027.42/96249> | en_US |
dc.identifier.issn | 0736-0266 | en_US |
dc.identifier.issn | 1554-527X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/96249 | |
dc.description.abstract | Knowledge of the extent to which tibial plateau cartilage displays non‐uniform mechanical topography under physiologically relevant loading conditions is critical to evaluating the role of biomechanics in knee osteoarthritis. Cartilage explants from 21 tibial plateau sites of eight non‐osteoarthritic female cadaveric knees (age: 41–54; BMI: 14–20) were tested in unconfined compression at 100% strain/s. The elastic tangent modulus at 10% strain ( E 10% ) was calculated for each site and averaged over four geographic regions: not covered by meniscus (I); covered by meniscus—anterior (II); covered by meniscus—exterior (III); and covered by meniscus—posterior (IV). A repeated‐measures mixed model analysis of variance was used to test for effects of plateau, region, and their interaction on E 10% . Effect sizes were calculated for each region pair. E 10% was significantly different ( p < 0.05) for all regional comparisons, except I–II and III–IV. The regional pattern of variation was consistent across individuals. Moderate to strong effect sizes were evident for regional comparisons other than I–II on the lateral side and III–IV on both sides. Healthy tibial cartilage exhibits significant mechanical heterogeneity that manifests in a common regional pattern across individuals. These findings provide a foundation for evaluating the biomechanical mechanisms of knee osteoarthritis. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 370–375, 2013 | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Mechanics | en_US |
dc.subject.other | Osteoarthritis | en_US |
dc.subject.other | Cartilage | en_US |
dc.subject.other | Knee | en_US |
dc.subject.other | Heterogeneity | en_US |
dc.title | Heterogeneity of tibial plateau cartilage in response to a physiological compressive strain rate | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | School of Kinesiology, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Program in Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | School of Kinesiology, University of Michigan, Ann Arbor, Michigan 48109. T: 248‐568‐6369; F: 734‐764‐5237. | en_US |
dc.identifier.pmid | 22952052 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/96249/1/22226_ftp.pdf | |
dc.identifier.doi | 10.1002/jor.22226 | en_US |
dc.identifier.source | Journal of Orthopaedic Research | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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