Urinary Concentrations of Di(2‐ethylhexyl) Phthalate Metabolites and Serum Reproductive Hormones: Pooled Analysis of Fertile and Infertile Men
dc.contributor.author | Mendiola, Jaime | en_US |
dc.contributor.author | Meeker, John D. | en_US |
dc.contributor.author | Jørgensen, Niels | en_US |
dc.contributor.author | Andersson, Anna‐maria | en_US |
dc.contributor.author | Liu, Fan | en_US |
dc.contributor.author | Calafat, Antonia M. | en_US |
dc.contributor.author | Redmon, J. Bruce | en_US |
dc.contributor.author | Drobnis, Erma Z. | en_US |
dc.contributor.author | Sparks, Amy E. | en_US |
dc.contributor.author | Wang, Christina | en_US |
dc.contributor.author | Hauser, Russ | en_US |
dc.contributor.author | Swan, Shanna H. | en_US |
dc.date.accessioned | 2013-02-12T19:00:29Z | |
dc.date.available | 2013-07-01T14:33:05Z | en_US |
dc.date.issued | 2012-05-06 | en_US |
dc.identifier.citation | Mendiola, Jaime; Meeker, John D.; Jørgensen, Niels ; Andersson, Anna‐maria ; Liu, Fan; Calafat, Antonia M.; Redmon, J. Bruce; Drobnis, Erma Z.; Sparks, Amy E.; Wang, Christina; Hauser, Russ; Swan, Shanna H. (2012). "Urinary Concentrations of Di(2â ethylhexyl) Phthalate Metabolites and Serum Reproductive Hormones: Pooled Analysis of Fertile and Infertile Men." Journal of Andrology 33(3). <http://hdl.handle.net/2027.42/96269> | en_US |
dc.identifier.issn | 0196-3635 | en_US |
dc.identifier.issn | 1939-4640 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/96269 | |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.subject.other | Anti‐Androgens | en_US |
dc.subject.other | Endocrine Disruptor | en_US |
dc.subject.other | Male Hormones | en_US |
dc.subject.other | DEHP Metabolites | en_US |
dc.title | Urinary Concentrations of Di(2‐ethylhexyl) Phthalate Metabolites and Serum Reproductive Hormones: Pooled Analysis of Fertile and Infertile Men | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Urology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Obstetrics, Gynecology, and Women's Health, School of Medicine, University of Missouri, Columbia, Missouri | en_US |
dc.contributor.affiliationother | Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa | en_US |
dc.contributor.affiliationother | Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York | en_US |
dc.contributor.affiliationother | Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | Vincent Memorial Obstetrics and Gynecology Service, Andrology Laboratory and In Vitro Fertilization Unit, Massachusetts General Hospital, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | Division of Endocrinology, Department of Medicine, Harbor‐UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California | en_US |
dc.contributor.affiliationother | Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, Rochester, New York | en_US |
dc.contributor.affiliationother | University Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark | en_US |
dc.contributor.affiliationother | Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia | en_US |
dc.contributor.affiliationother | Departments of Medicine and Urologic Surgery, University of Minnesota Medical School, Minneapolis, Minnesota | en_US |
dc.identifier.pmid | 21597090 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/96269/1/jandrol.111.013557.pdf | |
dc.identifier.doi | 10.2164/jandrol.111.013557 | en_US |
dc.identifier.source | Journal of Andrology | en_US |
dc.identifier.citedreference | Parmar D., Srivastava SP, Seth PK. Effect of di(2‐ethylhexyl) phthalate (DEHP) on spermatogenesis in adult rats. Toxicology. 1986; 42: 47 – 55. | en_US |
dc.identifier.citedreference | Duty SM, Calafat AM, Silva MJ, Ryan L., Hauser R.. Phthalate exposure and reproductive hormones in adult men. Hum Reprod. 2005; 20: 604 – 610. | en_US |
dc.identifier.citedreference | Gray LE Jr, Ostby J., Furr J., Price M., Veeramachaneni DN, Parks L.. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci. 2000; 58: 350 – 365. | en_US |
dc.identifier.citedreference | Hauser R., Calafat AM. Phthalates and human health. Occup Environ Med. 2005; 62: 806 – 818. | en_US |
dc.identifier.citedreference | Hauser R., Meeker JD, Duty S., Silva MJ, Calafat AM. Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology. 2006; 17: 682 – 691. | en_US |
dc.identifier.citedreference | Hauser R., Meeker JD, Park S., Silva MJ, Calafat AM. Temporal variability of urinary phthalate metabolite levels in men of reproductive age. Environ Health Perspect. 2004; 112: 1734 – 1740. | en_US |
dc.identifier.citedreference | Heindel JJ, Gulati DK, Mounce RC, Russell SR, Lamb JC 4th. Reproductive toxicity of three phthalic acid esters in a continuous breeding protocol. Fundam Appl Toxicol. 1989; 12: 508 – 518. | en_US |
dc.identifier.citedreference | Higuchi TT, Palmer JS, Gray LE Jr, Veeramachaneni DN. Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure. Toxicol Sci. 2003; 72: 301 – 313. | en_US |
dc.identifier.citedreference | Hoppin JA, Brock JW, Davis BJ, Baird DD. Reproducibility of urinary phthalate metabolites in first morning urine samples. Environ Health Perspect. 2002; 110: 515 – 518. | en_US |
dc.identifier.citedreference | Hornung RW, Reed LD. Estimation of average concentration in the presence of non‐detectable values. Appl Occup Environ Hyg. 1990; 5: 48 – 51. | en_US |
dc.identifier.citedreference | Jönsson BA, Richthoff J., Rylander L., Giwercman A., Hagmar L.. Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology. 2005; 16: 487 – 493. | en_US |
dc.identifier.citedreference | Jørgensen N., Meyts E. Rajpert‐De, Main KM, Skakkebæk NE. Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis. Int J Androl. 2010; 33: 298 – 303. | en_US |
dc.identifier.citedreference | Li LH, Jester WF Jr, Laslett AL, Orth JM. A single dose of di‐(2‐ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces sertoli cell proliferation, and decreases cyclin D2 expression. Toxicol Appl Pharmacol. 2000; 166: 222 – 229. | en_US |
dc.identifier.citedreference | Li LH, Jester WF Jr, Orth JM. Effects of relatively low levels of mono‐(2‐ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats. Toxicol Appl Pharmacol. 1998; 153: 258 – 265. | en_US |
dc.identifier.citedreference | Lovekamp TN, Davis BJ. Mono‐(2‐ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells. Toxicol Appl Pharmacol. 2001; 172: 217 – 224. | en_US |
dc.identifier.citedreference | Main KM, Mortensen GK, Kaleva MM, Boisen KA, Damgaard IN, Chellakooty M., Schmidt IM, Suomi AM, Virtanen HE, Petersen DV, Andersson AM, Toppari J., Skakkebaek NE. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect. 2006; 114: 270 – 276. | en_US |
dc.identifier.citedreference | Meeker JD, Calafat AM, Hauser R.. Urinary metabolites of di(2‐ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men. J Androl. 2009; 30: 287 – 297. | en_US |
dc.identifier.citedreference | Mendiola J., Jørgensen N., Andersson AM, Calafat AM, Silva MJ, Redmon JB, Sparks A., Drobnis EZ, Wang C., Liu F., Swan SH. Associations between urinary metabolites of di(2‐ethylhexyl) phthalate and reproductive hormones in fertile men. Int J Androl. 2011; 34: 369 – 378. | en_US |
dc.identifier.citedreference | National Research Council. Hormonally Active Agents in the Environment. Washington, DC: National Research Council, National Academies Press; 1999. | en_US |
dc.identifier.citedreference | Noda M., Ohno S., Nakajin S.. Mono‐(2‐ethylhexyl) phthalate (MEHP) induces nuclear receptor 4A subfamily in NCI‐H295R cells: a possible mechanism of aromatase suppression by MEHP. Mol Cell Endocrinol. 2007; 274: 8 – 18. | en_US |
dc.identifier.citedreference | Pan G., Hanaoka T., Yoshimura M., Zhang S., Wang P., Tsukino H., Inoue K., Nakazawa H., Tsugane S., Takahashi K.. Decreased serum free testosterone in workers exposed to high levels of di‐n‐butyl phthalate (DBP) and di‐2‐ethylhexyl phthalate (DEHP): a cross‐sectional study in China. Environ Health Perspect. 2006; 114: 1643 – 1648. | en_US |
dc.identifier.citedreference | Parks LG, Ostby JS, Lambright CR, Abbott BD, Klinefelter GR, Barlow NJ, Gray LE Jr. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci. 2000; 58: 339 – 349. | en_US |
dc.identifier.citedreference | Pentikainen V., Erkkila K., Suomalainen L., Parvinen M., Dunkel L.. Estradiol acts as a germ cell survival factor in the human testis in vitro. J Clin Endocrinol Metab. 2000; 85: 2057 – 2067. | en_US |
dc.identifier.citedreference | Pitteloud N., Dwyer AA, DeCruz S., Lee H., Boepple PA, Crowley WF Jr, Hayes FJ. The relative role of gonadal sex steroids and gonadotropin‐releasing hormone pulse frequency in the regulation of follicle‐stimulating hormone secretion in men. J Clin Endocrinol Metab. 2008; 93: 2686 – 2692. | en_US |
dc.identifier.citedreference | Rosner W., Auchus RJ, Azziz R., Sluss PM, Raff H.. Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. J Clin Endocrinol Metab. 2007; 92: 405 – 413. | en_US |
dc.identifier.citedreference | Sharpe RM, Skakkebæk NE. Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects. Fertil Steril. 2008; 89 ( 2suppl ): 33 – 38. | en_US |
dc.identifier.citedreference | Sikaris K., McLachlan RI, Kazlauskas R., de Kretser D., Holden CA, Handelsman DJ. Reproductive hormone reference intervals for healthy fertile young men: evaluation of automated platform assays. J Clin Endocrinol Metab. 2005; 90: 5928 – 5936. | en_US |
dc.identifier.citedreference | Silva MJ, Samandar E., Preau JL, Reidy JA, Needham LL, Calafat AM. Quantification of 22 phthalate metabolites in human urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2007; 860: 106 – 112. | en_US |
dc.identifier.citedreference | Srivastava SP, Srivastava S., Saxena DK, Chandra SV, Seth PK. Testicular effects of di‐n‐butyl phthalate (DBP): biochemical and histopathological alterations. Arch Toxicol. 1990; 64: 148 – 152. | en_US |
dc.identifier.citedreference | Swan SH. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res. 2008; 108: 177 – 184. | en_US |
dc.identifier.citedreference | Swan SH, Brazil C., Drobnis EZ, Liu F., Kruse RL, Hatch M., Redmon JB, Wang C., Overstreet JW. Geographic differences in semen quality of fertile U.S. males. Environ Health Perspect. 2003; 111: 414 – 420. | en_US |
dc.identifier.citedreference | Swan SH, Elkin EP, Fenster L.. Have sperm densities declined? A reanalysis of global trend data. Environ Health Perspect. 1997; 105: 1228 – 1232. | en_US |
dc.identifier.citedreference | Swan SH, Main KM, Liu F., Stewart SL, Kruse RL, Calafat AM, Mao CS, Redmon JB, Ternand CL, Sullivan S., Teague JL. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect. 2005; 113: 1056 – 1061. | en_US |
dc.identifier.citedreference | Taieb J., Mathian B., Millot F., Patricot MC, Mathieu E., Queyrel N., Lacroix I., Somma‐Delpero C., Boudou P.. Testosterone measured by 10 immunoassays and by isotope‐dilution gas chromatography–mass spectrometry in sera from 116 men, women, and children. Clin Chem. 2003; 49: 1381 – 1395. | en_US |
dc.identifier.citedreference | Talsness CE, Andrade AJ, Kuriyama SN, Taylor JA, vom Saal FS. Components of plastic: experimental studies in animals and relevance for human health. Philos Trans R Soc Lond B Biol Sci. 2009; 364: 2079 – 2096. | en_US |
dc.identifier.citedreference | Teitelbaum SL, Britton JA, Calafat AM, Ye X., Silva MJ, Reidy JA, Galvez MP, Brenner BL, Wolff MS. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ Res. 2008; 106: 257 – 269. | en_US |
dc.identifier.citedreference | Thompson RC, Moore CJ, vom Saal FS, Swan SH. Plastics, the environment and human health: current consensus and future trends. Philos Trans R Soc Lond B Biol Sci. 2009; 364: 2153 – 2166. | en_US |
dc.identifier.citedreference | Travison TG, Araujo AB, O'Donnell AB, Kupelian V., McKinlay JB. A population‐level decline in serum testosterone levels in American men. J Clin Endocrinol Metab. 2007; 92: 196 – 202. | en_US |
dc.identifier.citedreference | Vermeulen A., Verdonck L., Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999; 84: 3666 – 3672. | en_US |
dc.identifier.citedreference | Wang C., Catlin DH, Demers LM, Starcevic B., Swerdloff RS. Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography–tandem mass spectrometry. J Clin Endocrinol Metab. 2004; 89: 534 – 543. | en_US |
dc.identifier.citedreference | Agency for Toxic Substances and Disease Registry. Toxicological Profile for Di(2‐ethylhexyl)phthalate (DEHP). Atlanta, GA: Agency for Toxic Substances and Disease Registry; 2002. | en_US |
dc.identifier.citedreference | Andersson AM, Jensen TK, Juul A., Petersen JH, Jorgensen T., Skakkebaek NE. Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys. J Clin Endocrinol Metab. 2007; 92: 4696 – 4705. | en_US |
dc.identifier.citedreference | Andrade A., Grande SW, Talsness CE, Grote K., Chahoud I.. A doseresponse study following in utero and lactational exposure to di‐(2‐ethylhexyl)‐phthalate (DEHP): non‐monotonic dose‐response and low dose effects on rat brain aromatase activity. Toxicology. 2006; 227: 185 – 192. | en_US |
dc.identifier.citedreference | Asklund C., Jørgensen N., Skakkebaek NE, Jensen TK. Increased frequency of reproductive health problems among fathers of boys with hypospadias. Hum Reprod. 2007; 22: 2639 – 2646. | en_US |
dc.identifier.citedreference | Bang AK, Carlsen E., Holm M., Petersen JH, Skakkebaek NE, Jørgensen N.. A study of finger lengths, semen quality and sex hormones in 360 young men from the general Danish population. Hum Reprod. 2005; 20: 3109 – 3113. | en_US |
dc.identifier.citedreference | Bjornerem A., Straume B., Oian P., Berntsen GK. Seasonal variation of estradiol, follicle stimulating hormone, and dehydroepiandrosterone sulfate in women and men. J Clin Endocrinol Metab. 2006; 91: 3798 – 3802. | en_US |
dc.identifier.citedreference | Borch J., Metzdorff SB, Vinggaard AM, Brokken L., Dalgaard M.. Mechanisms underlying the anti‐androgenic effects of diethylhexyl phthalate in fetal rat testis. Toxicology. 2006; 223: 144 – 155. | en_US |
dc.identifier.citedreference | Box GEP, Tidwell PW. Transformation of the independent variables. Technometrics. 1962; 5: 531 – 550. | en_US |
dc.identifier.citedreference | Carlsen E., Giwercman A., Keiding N., Skakkebaek NE. Evidence for decreasing quality of semen during the past 50 years. BMJ. 1992; 305: 609 – 613. | en_US |
dc.identifier.citedreference | Centers for Disease Control and Prevention (CDC). Fourth National Report on Human Exposure to Environmental Chemicals. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Environmental Health; 2011. http:www.cdc.govexposurereportpdfUpdated_Tables.pdf. Accessed February 1, 2011. | en_US |
dc.identifier.citedreference | Davis BJ, Weaver R., Gaines LJ, Heindel JJ. Mono‐(2‐ethylhexyl) phthalate suppresses estradiol production independent of FSH‐cAMP stimulation in rat granulosa cells. Toxicol Appl Pharmacol. 1994; 128: 224 – 228. | en_US |
dc.identifier.citedreference | Dostal LA, Chapin RE, Stefanski SA, Harris MW, Schwetz BA. Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2‐ethylhexyl)phthalate and the recovery of fertility as adults. Toxicol Appl Pharmacol. 1988; 95: 104 – 121. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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