Variation in the Composition and In Vitro Proinflammatory Effect of Urban Particulate Matter from Different Sites
dc.contributor.author | Manzano‐león, Natalia | en_US |
dc.contributor.author | Quintana, Raúl | en_US |
dc.contributor.author | Sánchez, Brisa | en_US |
dc.contributor.author | Serrano, Jesús | en_US |
dc.contributor.author | Vega, Elizabeth | en_US |
dc.contributor.author | Vázquez‐lópez, Inés | en_US |
dc.contributor.author | Rojas‐bracho, Leonora | en_US |
dc.contributor.author | López‐villegas, Tania | en_US |
dc.contributor.author | O'Neill, Marie S. | en_US |
dc.contributor.author | Vadillo‐ortega, Felipe | en_US |
dc.contributor.author | De Vizcaya‐ruiz, Andrea | en_US |
dc.contributor.author | Rosas, Irma | en_US |
dc.contributor.author | Osornio‐vargas, Álvaro R. | en_US |
dc.date.accessioned | 2013-02-12T19:00:49Z | |
dc.date.available | 2014-03-03T15:09:24Z | en_US |
dc.date.issued | 2013-01 | en_US |
dc.identifier.citation | Manzano‐león, Natalia ; Quintana, Raúl ; Sánchez, Brisa ; Serrano, Jesús ; Vega, Elizabeth; Vázquez‐lópez, Inés ; Rojas‐bracho, Leonora ; López‐villegas, Tania ; O'Neill, Marie S.; Vadillo‐ortega, Felipe ; De Vizcaya‐ruiz, Andrea ; Rosas, Irma; Osornio‐vargas, Álvaro R. (2013). "Variation in the Composition and In Vitro Proinflammatory Effect of Urban Particulate Matter from Different Sites." Journal of Biochemical and Molecular Toxicology 27(1): 87-97. <http://hdl.handle.net/2027.42/96321> | en_US |
dc.identifier.issn | 1095-6670 | en_US |
dc.identifier.issn | 1099-0461 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/96321 | |
dc.description.abstract | Spatial variation in particulate matter–related health and toxicological outcomes is partly due to its composition. We studied spatial variability in particle composition and induced cellular responses in Mexico City to complement an ongoing epidemiologic study. We measured elements, endotoxins, and polycyclic aromatic hydrocarbons in two particle size fractions collected in five sites. We compared the in vitro proinflammatory response of J774A.1 and THP‐1 cells after exposure to particles, measuring subsequent TNFα and IL‐6 secretion. Particle composition varied by site and size. Particle constituents were subjected to principal component analysis, identifying three components: C 1 (Si, Sr, Mg, Ca, Al, Fe, Mn, endotoxin), C 2 (polycyclic aromatic hydrocarbons), and C 3 (Zn, S, Sb, Ni, Cu, Pb). Induced TNFα levels were higher and more heterogeneous than IL‐6 levels. Cytokines produced by both cell lines only correlated with C 1 , suggesting that constituents associated with soil induced the inflammatory response and explain observed spatial differences. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:87‐97, 2013; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.21471 | en_US |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.publisher | Instituto Nacional de Ecología | en_US |
dc.subject.other | Particulate Matter (PM) | en_US |
dc.subject.other | Chemical Composition | en_US |
dc.subject.other | Spatial Variation | en_US |
dc.subject.other | Cytokines | en_US |
dc.subject.other | Soil | en_US |
dc.title | Variation in the Composition and In Vitro Proinflammatory Effect of Urban Particulate Matter from Different Sites | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 23335408 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/96321/1/jbt21471.pdf | |
dc.identifier.doi | 10.1002/jbt.21471 | en_US |
dc.identifier.source | Journal of Biochemical and Molecular Toxicology | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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