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Variation in the Composition and In Vitro Proinflammatory Effect of Urban Particulate Matter from Different Sites

dc.contributor.authorManzano‐león, Nataliaen_US
dc.contributor.authorQuintana, Raúlen_US
dc.contributor.authorSánchez, Brisaen_US
dc.contributor.authorSerrano, Jesúsen_US
dc.contributor.authorVega, Elizabethen_US
dc.contributor.authorVázquez‐lópez, Inésen_US
dc.contributor.authorRojas‐bracho, Leonoraen_US
dc.contributor.authorLópez‐villegas, Taniaen_US
dc.contributor.authorO'Neill, Marie S.en_US
dc.contributor.authorVadillo‐ortega, Felipeen_US
dc.contributor.authorDe Vizcaya‐ruiz, Andreaen_US
dc.contributor.authorRosas, Irmaen_US
dc.contributor.authorOsornio‐vargas, Álvaro R.en_US
dc.date.accessioned2013-02-12T19:00:49Z
dc.date.available2014-03-03T15:09:24Zen_US
dc.date.issued2013-01en_US
dc.identifier.citationManzano‐león, Natalia ; Quintana, Raúl ; Sánchez, Brisa ; Serrano, Jesús ; Vega, Elizabeth; Vázquez‐lópez, Inés ; Rojas‐bracho, Leonora ; López‐villegas, Tania ; O'Neill, Marie S.; Vadillo‐ortega, Felipe ; De Vizcaya‐ruiz, Andrea ; Rosas, Irma; Osornio‐vargas, Álvaro R. (2013). "Variation in the Composition and In Vitro Proinflammatory Effect of Urban Particulate Matter from Different Sites." Journal of Biochemical and Molecular Toxicology 27(1): 87-97. <http://hdl.handle.net/2027.42/96321>en_US
dc.identifier.issn1095-6670en_US
dc.identifier.issn1099-0461en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/96321
dc.description.abstractSpatial variation in particulate matter–related health and toxicological outcomes is partly due to its composition. We studied spatial variability in particle composition and induced cellular responses in Mexico City to complement an ongoing epidemiologic study. We measured elements, endotoxins, and polycyclic aromatic hydrocarbons in two particle size fractions collected in five sites. We compared the in vitro proinflammatory response of J774A.1 and THP‐1 cells after exposure to particles, measuring subsequent TNFα and IL‐6 secretion. Particle composition varied by site and size. Particle constituents were subjected to principal component analysis, identifying three components: C 1 (Si, Sr, Mg, Ca, Al, Fe, Mn, endotoxin), C 2 (polycyclic aromatic hydrocarbons), and C 3 (Zn, S, Sb, Ni, Cu, Pb). Induced TNFα levels were higher and more heterogeneous than IL‐6 levels. Cytokines produced by both cell lines only correlated with C 1 , suggesting that constituents associated with soil induced the inflammatory response and explain observed spatial differences. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:87‐97, 2013; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.21471en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.publisherInstituto Nacional de Ecologíaen_US
dc.subject.otherParticulate Matter (PM)en_US
dc.subject.otherChemical Compositionen_US
dc.subject.otherSpatial Variationen_US
dc.subject.otherCytokinesen_US
dc.subject.otherSoilen_US
dc.titleVariation in the Composition and In Vitro Proinflammatory Effect of Urban Particulate Matter from Different Sitesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid23335408en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/96321/1/jbt21471.pdf
dc.identifier.doi10.1002/jbt.21471en_US
dc.identifier.sourceJournal of Biochemical and Molecular Toxicologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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