Smoking status and survival in the national comprehensive cancer network non–small cell lung cancer cohort
dc.contributor.author | Ferketich, Amy K. | en_US |
dc.contributor.author | Niland, Joyce C. | en_US |
dc.contributor.author | Mamet, Rizvan | en_US |
dc.contributor.author | Zornosa, Carrie | en_US |
dc.contributor.author | D'Amico, Thomas A. | en_US |
dc.contributor.author | Ettinger, David S. | en_US |
dc.contributor.author | Kalemkerian, Gregory P. | en_US |
dc.contributor.author | Pisters, Katherine M. | en_US |
dc.contributor.author | Reid, Mary E. | en_US |
dc.contributor.author | Otterson, Gregory A. | en_US |
dc.date.accessioned | 2013-02-12T19:00:56Z | |
dc.date.available | 2014-04-02T15:08:08Z | en_US |
dc.date.issued | 2013-02-15 | en_US |
dc.identifier.citation | Ferketich, Amy K.; Niland, Joyce C.; Mamet, Rizvan; Zornosa, Carrie; D'Amico, Thomas A.; Ettinger, David S.; Kalemkerian, Gregory P.; Pisters, Katherine M.; Reid, Mary E.; Otterson, Gregory A. (2013). "Smoking status and survival in the national comprehensive cancer network non–small cell lung cancer cohort." Cancer 119(4): 847-853. <http://hdl.handle.net/2027.42/96341> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/96341 | |
dc.description.abstract | BACKGROUND: The objectives of this study were to evaluate survival among current smokers, former smokers, and never smokers who are diagnosed with non–small cell lung cancer (NSCLC). METHODS: The study included patients who participated in the National Comprehensive Cancer Network's NSCLC Database Project. Current, former, and never smokers were compared with respect to overall survival by fitting Cox regression models. RESULTS: Data from 4200 patients were examined, including 618 never smokers, 1483 current smokers, 380 former smokers who quit 1 to 12 months before diagnosis, and 1719 former smokers who quit >12 months before diagnosis. Among patients with stage I, II, and III disease, only never smokers had better survival than current smokers (hazard ratio, 0.47 [95% confidence interval, 0.26‐0.85] vs 0.51 [95% confidence interval, 0.38‐0.68], respectively). Among patients with stage IV disease, the impact of smoking depended on age: Among younger patients (aged ≤55 years), being a never smoker and a former smoker for ≥12 months increased survival. After age 85 years, smoking status did not have a significant impact on overall survival. CONCLUSIONS: Patients who were smoking at the time of diagnosis had worse survival compared with never smokers. Among younger patients with stage IV disease, current smokers also had worse survival compared with former smokers who quit >12 months before diagnosis. It is likely that tumor biology plays a major role in the differences observed; however, to improve survival, it is prudent to encourage all smokers to quit smoking if they are diagnosed with NSCLC. Cancer 2013. © 2012 American Cancer Society. Patients who are smoking at the time of diagnosis have worse survival compared with never smokers. Although some of these differences probably are related to tumor biology, to improve survival, it is prudent to encourage all smokers to quit smoking if they are diagnosed with non–small cell lung cancer. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Smoking | en_US |
dc.subject.other | Prognosis | en_US |
dc.subject.other | Survival Analysis | en_US |
dc.subject.other | Smoking Cessation | en_US |
dc.subject.other | Non–Small Cell Lung Cancer | en_US |
dc.title | Smoking status and survival in the national comprehensive cancer network non–small cell lung cancer cohort | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Roswell Park Cancer Institute, Buffalo, New York | en_US |
dc.contributor.affiliationother | The Ohio State University College of Public Health and the Comprehensive Cancer Center, Columbus, Ohio | en_US |
dc.contributor.affiliationother | City of Hope Comprehensive Cancer Center, Duarte, California | en_US |
dc.contributor.affiliationother | National Comprehensive Cancer Network, Fort Washington, Pennsylvania | en_US |
dc.contributor.affiliationother | Duke Cancer Institute, Durham, North Carolina | en_US |
dc.contributor.affiliationother | The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | The University of Texas M. D. Anderson Cancer Center, Houston, Texas | en_US |
dc.contributor.affiliationother | The Ohio State University College of Medicine and the Comprehensive Cancer Center, Columbus, Ohio | en_US |
dc.contributor.affiliationother | The Ohio State University College of Public Health, 310 Cunz Hall, 1841 Neil Avenue, Columbus, OH 43210 | en_US |
dc.identifier.pmid | 23023590 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/96341/1/27824_ftp.pdf | |
dc.identifier.doi | 10.1002/cncr.27824 | en_US |
dc.identifier.source | Cancer | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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