View Item 

Show simple item record

Synthesis of potential antifilarial agents 2 . methyl 2‐substituted purine 8‐carbamates and related compounds
dc.contributor.authorRam, Siyaen_US
dc.contributor.authorEvans, Williamen_US
dc.contributor.authorWise, Dean S.en_US
dc.contributor.authorTownsend, Leroy B.en_US
dc.contributor.authorMccall, John W.en_US
dc.date.accessioned2013-02-12T19:00:58Z
dc.date.available2013-02-12T19:00:58Z
dc.date.issued1989-07en_US
dc.identifier.citationRam, Siya; Evans, William; Wise, Dean S.; Townsend, Leroy B.; Mccall, John W. (1989). "Synthesis of potential antifilarial agents 2 . methyl 2‐substituted purine 8‐carbamates and related compounds." Journal of Heterocyclic Chemistry 26(4): 1053-1059. <http://hdl.handle.net/2027.42/96345>en_US
dc.identifier.issn0022-152Xen_US
dc.identifier.issn1943-5193en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/96345
dc.description.abstractA series of methyl 2‐substituted purine 8‐carbamates was prepared and evaluated for antifilarial activity. These purines were synthesized as aza congeners of benzimidazole carbamates which have shown significant anthelmintic activity to determine the effect that this modification might have on anthelmintic activity. The compounds were tested against the filarial infection, B. pahangi , in jirds. None of the compounds prepared in this study demonstrated antifilarial activity.en_US
dc.publisherWiley‐Blackwellen_US
dc.titleSynthesis of potential antifilarial agents 2 . methyl 2‐substituted purine 8‐carbamates and related compoundsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOrganic Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Medicinal Chemistry, College of Pharmacy, and Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109‐1065en_US
dc.contributor.affiliationotherDepartment of Parasitology, College of Veterinary Medicine, University of Georgia, Athens, Ga 30602en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/96345/1/5570260427_ftp.pdf
dc.identifier.doi10.1002/jhet.5570260427en_US
dc.identifier.sourceJournal of Heterocyclic Chemistryen_US
dc.identifier.citedreferenceD. R. Shridhar, K. S. Rao, K. K. Bhopale, H. N. Tripathi and G. S. T. Sai, Indian J. Chem., 19B, 699 ( 1980 ).en_US
dc.identifier.citedreferenceG. L. Dunn, A. Wayne and R. V. Berthald,U. S. Patent 3,536,711( 1970 ); Chem. Abstr., 74, 22887 ( 1971 ).en_US
dc.identifier.citedreferenceD. A. Denham, A. E. Brandt and D. A. Liron, J. Parasitol., 67, 123 ( 1981 ).en_US
dc.identifier.citedreferenceJ. W. McCall and H. H. Crouthannel, J. Parasitol., 62, 844 ( 1976 ).en_US
dc.identifier.citedreferenceS. Ram, D. S. Wise and L. B. Townsend, Heterocycles, 22, 1789 ( 1984 ).en_US
dc.identifier.citedreferenceA. H. M. Raeymakers, J. L. H. VanGelder, L. F. C. Roevens and P. A. J. Janssen, Arzneim.‐Forsch., 28, 586 ( 1978 ).en_US
dc.identifier.citedreferenceR. K. Robins, K. L. Dille and B. E. Christensen, J. Org. Chem., 19, 930 ( 1954 ).en_US
dc.identifier.citedreferenceD. J. Brown, J. Appl. Chem., 2, 239 ( 1952 ).en_US
dc.identifier.citedreferenceD. A. Denham — Personal communication.en_US
dc.identifier.citedreferenceG. B. Elion and G. H. Hitchings, J. Am. Chem. Soc., 69, 2553 ( 1947 ).en_US
dc.identifier.citedreferenceWHO Scientific Working Group on Filariasis Report No. TDR/FIL‐SWG, (3), 79.3( 1979 ).en_US
dc.identifier.citedreferenceV. J. Theodorides, R. J. Gyurik, W. D. Kingsbury and R. C. Parish, Experientia, 32, 702 ( 1976 ).en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
5570260427_ftp.pdf
Size:
481.3KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.