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Mass spectrometry of nucleoside derivatives. Seleno analogs of purine and pyrimidine bases and nucleosides
dc.contributor.authorLiehr, J. G.en_US
dc.contributor.authorWeise, C. L.en_US
dc.contributor.authorWise, Dean S.en_US
dc.contributor.authorTownsend, Leroy B.en_US
dc.contributor.authorCrain, P. F.en_US
dc.contributor.authorMilne, Georgeen_US
dc.contributor.authorMccloskey, James A.en_US
dc.date.accessioned2013-02-12T19:01:01Z
dc.date.available2013-02-12T19:01:01Z
dc.date.issued1979-09en_US
dc.identifier.citationLiehr, J. G.; Weise, C. L.; Wise, Dean S.; Townsend, Leroy B.; Crain, P. F.; Milne, George; Mccloskey, James A. (1979). "Mass spectrometry of nucleoside derivatives. Seleno analogs of purine and pyrimidine bases and nucleosides." Journal of Heterocyclic Chemistry 16(6): 1263-1272. <http://hdl.handle.net/2027.42/96358>en_US
dc.identifier.issn0022-152Xen_US
dc.identifier.issn1943-5193en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/96358
dc.description.abstract10.1002/jhet.5570160634.abs Mass spectra of certain selenobases and selenonucleosides, and some of their trimethylsilyl and O,N ‐permethyl derivatives have been studied from the standpoint of structural characterization, and in order to ascertain the influence of selenium on normal fragmentation patterns. Molecular ion abundances of the selenouracils are intermediate between those of the corresponding oxygen and sulfur analogs. Fragmentation processes are similar to those of the corresponding normal bases and nucleosides but with additional ions resulting from expulsion of Se or SeH in most cases. Trimethylsilylation occurs at approximately the same rate as for normal bases and nucleosides but the products show decreasing stability with prolonged heating. A least squares procedure is demonstrated which generates monoisotopic mass patterns and assists in interpretation of the mass spectra.en_US
dc.publisherWiley‐Blackwellen_US
dc.titleMass spectrometry of nucleoside derivatives. Seleno analogs of purine and pyrimidine bases and nucleosidesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOrganic Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109en_US
dc.contributor.affiliationotherDepartments of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112en_US
dc.contributor.affiliationotherInstitute for Lipid Research, Baylor College of Medicine, Houston, Texas 77025en_US
dc.contributor.affiliationotherDepartments of Medicinal Chemistry and Biochemistry, University of Utah, Salt Lake City, Utah 84112en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/96358/1/5570160634_ftp.pdf
dc.identifier.doi10.1002/jhet.5570160634en_US
dc.identifier.sourceJournal of Heterocyclic Chemistryen_US
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dc.identifier.citedreferenceIt is noted that the two published mass spectra of inosine show numerous differences (22,23), one exhibiting m/e 27, 28 as the most intense ions in the spectrum (22).en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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