Single‐fraction radiotherapy versus multifraction radiotherapy for palliation of painful vertebral bone metastases—Equivalent efficacy, less toxicity, more convenient
dc.contributor.author | Howell, David D. | en_US |
dc.contributor.author | James, Jennifer L. | en_US |
dc.contributor.author | Hartsell, William F. | en_US |
dc.contributor.author | Suntharalingam, Mohan | en_US |
dc.contributor.author | Machtay, Mitchell | en_US |
dc.contributor.author | Suh, John H. | en_US |
dc.contributor.author | Demas, William F. | en_US |
dc.contributor.author | Sandler, Howard M. | en_US |
dc.contributor.author | Kachnic, Lisa A. | en_US |
dc.contributor.author | Berk, Lawrence B. | en_US |
dc.date.accessioned | 2013-02-12T19:01:10Z | |
dc.date.available | 2014-04-02T15:08:08Z | en_US |
dc.date.issued | 2013-02-15 | en_US |
dc.identifier.citation | Howell, David D.; James, Jennifer L.; Hartsell, William F.; Suntharalingam, Mohan; Machtay, Mitchell; Suh, John H.; Demas, William F.; Sandler, Howard M.; Kachnic, Lisa A.; Berk, Lawrence B. (2013). "Single‐fraction radiotherapy versus multifraction radiotherapy for palliation of painful vertebral bone metastases—Equivalent efficacy, less toxicity, more convenient ." Cancer 119(4): 888-896. <http://hdl.handle.net/2027.42/96380> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/96380 | |
dc.description.abstract | BACKGROUND: The Radiation Therapy Oncology Group (RTOG) trial 97‐14 revealed no difference between radiation delivered for painful bone metastases at a dose of 8 gray (Gy) in 1 fraction (single‐fraction radiotherapy [SFRT]) and 30 Gy in 10 fractions (multifraction radiotherapy [MFRT]) in pain relief or narcotic use 3 months after randomization. SFRT for painful vertebral bone metastases (PVBM) has not been well accepted, possibly because of concerns about efficacy and toxicity. In the current study, the authors evaluated the subset of patients that was treated specifically for patients with PVBM. METHODS: PVBM included the cervical, thoracic, and/or lumbar spine regions. Among patients with PVBM, differences in retreatment rates and in pain relief, narcotic use, and toxicity 3 months after randomization were evaluated. RESULTS: Of 909 eligible patients, 235 (26%) had PVBM. Patients with and without PVBM differed in terms of the percentage of men (55% vs 47%, respectively; P = .03) and the proportion of patients with multiple painful sites (57% vs 38%, respectively; P < .01). Among those with PVBM, more patients who received MFRT had multiple sites treated (65% vs 49% for MFRT vs SFRT, respectively; P = .02). There were no statistically significant treatment differences in terms of pain relief (62% vs 70% for MFRT vs SFRT, respectively; P = .59) or freedom from narcotic use (24% vs 27%, respectively; P = .76) at 3 months. Significant differences in acute grade 2 through 4 toxicity (20% vs 10% for MFRT vs SFRT, respectively; P = .01) and acute grade 2 through 4 gastrointestinal toxicity (14% vs 6%, respectively; P = .01) were observed at 3 months, with lower toxicities seen in the patients treated with SFRT. Late toxicity was rare. No myelopathy was recorded. SFRT produced higher 3‐year retreatment rates (5% vs 15%; P = .01). CONCLUSIONS: Results for the subset of patients with PVBM in the RTOG 94‐17 randomized controlled trial were comparable to those for the entire population. SFRT produced less acute toxicity and a higher rate of retreatment than MFRT. SFRT and MFRT resulted in comparable pain relief and narcotic use at 3 months. Cancer 2013. © 2012 American Cancer Society. Single‐fraction radiation therapy and multifraction radiation therapy for painful vertebral bone metastases result in comparable pain relief and freedom from narcotic use at 3 months in a subset analysis of patients from the randomized, controlled trial Radiation Therapy Oncology Group 97‐14. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Palliative Care | en_US |
dc.subject.other | Radiation Oncology | en_US |
dc.subject.other | Late Effects | en_US |
dc.subject.other | Spine Malignancy | en_US |
dc.subject.other | Stereotactic Radiation Therapy | en_US |
dc.subject.other | Single‐Fraction Radiation | en_US |
dc.subject.other | Metastases | en_US |
dc.subject.other | Supportive Care | en_US |
dc.subject.other | Pain Management | en_US |
dc.subject.other | Bone Metastases | en_US |
dc.title | Single‐fraction radiotherapy versus multifraction radiotherapy for palliation of painful vertebral bone metastases—Equivalent efficacy, less toxicity, more convenient | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, University of Michigan, UHB2C490, SPC 5010, 1500 East Medical Center Drive, Ann Arbor, MI 48109‐5010 | en_US |
dc.contributor.affiliationother | H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida | en_US |
dc.contributor.affiliationother | Radiation Therapy Oncology Group Statistical Center, Philadelphia, Pennsylvania | en_US |
dc.contributor.affiliationother | Department of Radiation Oncology, Advocate Good Shepherd Hospital, Barrington, Illinois | en_US |
dc.contributor.affiliationother | Department of Radiation Oncology, University of Maryland Medical System, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania | en_US |
dc.contributor.affiliationother | Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio | en_US |
dc.contributor.affiliationother | Department of Radiation Oncology, Jean and Milton Cooper Cancer Center, Summa Akron City Hospital, Akron, Ohio | en_US |
dc.contributor.affiliationother | Department of Radiation Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars‐Sinai Medical Center, Los Angeles, California | en_US |
dc.contributor.affiliationother | Department of Radiation Oncology, Boston Medical Center, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | Department of Radiation Oncology, Case Western Reserve University School of Medicine, Cleveland, Ohio | en_US |
dc.identifier.pmid | 23165743 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/96380/1/27616_ftp.pdf | |
dc.identifier.doi | 10.1002/cncr.27616 | en_US |
dc.identifier.source | Cancer | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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