Urinary Metabolites of Di(2‐ethylhexyl) Phthalate Are Associated With Decreased Steroid Hormone Levels in Adult Men
dc.contributor.author | Meeker, John D. | en_US |
dc.contributor.author | Calafat, Antonia M. | en_US |
dc.contributor.author | Hauser, Russ | en_US |
dc.date.accessioned | 2013-02-12T19:01:21Z | |
dc.date.available | 2013-02-12T19:01:21Z | |
dc.date.issued | 2009-05-06 | en_US |
dc.identifier.citation | Meeker, John D.; Calafat, Antonia M.; Hauser, Russ (2009). "Urinary Metabolites of Di(2‐ethylhexyl) Phthalate Are Associated With Decreased Steroid Hormone Levels in Adult Men." Journal of Andrology 30(3). <http://hdl.handle.net/2027.42/96413> | en_US |
dc.identifier.issn | 0196-3635 | en_US |
dc.identifier.issn | 1939-4640 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/96413 | |
dc.publisher | Wiley Periodicals, Inc. | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.subject.other | Testosterone | en_US |
dc.subject.other | Biomarker | en_US |
dc.subject.other | Environment | en_US |
dc.subject.other | Human | en_US |
dc.subject.other | Estrogen | en_US |
dc.subject.other | Male Reproduction | en_US |
dc.subject.other | Endocrine | en_US |
dc.subject.other | Androgen | en_US |
dc.title | Urinary Metabolites of Di(2‐ethylhexyl) Phthalate Are Associated With Decreased Steroid Hormone Levels in Adult Men | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Urology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | Vincent Memorial Obstetrics and Gynecology Service, Andrology Laboratory and In Vitro Fertilization Unit, Massachusetts General Hospital, Boston, Massachusetts. | en_US |
dc.contributor.affiliationother | Centers for Disease and Control and Prevention, Atlanta, Georgia | en_US |
dc.identifier.pmid | 19059903 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/96413/1/jandrol.108.006403.pdf | |
dc.identifier.doi | 10.2164/jandrol.108.006403 | en_US |
dc.identifier.source | Journal of Andrology | en_US |
dc.identifier.citedreference | Pan G., Hanaoka T., Yoshimura M., Zhang S., Wang P., Tsukino H., Inoue K., Nakazawa H., Tsugane S., Takahashi K.. Decreased serum free testosterone in workers exposed to high levels of di‐n‐butyl phthalate (DBP) and di‐2‐ethylhexyl phthalate (DEHP): a cross‐sectional study in China. Environ Health Perspect. 2006; 114 ( 11 ): 1643 – 1648. | en_US |
dc.identifier.citedreference | Hauser R., Meeker JD, Singh NP, Silva MJ, Ryan L., Duty S., Calafat AM. DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. Hum Reprod. 2007; 22 ( 3 ): 688 – 695. | en_US |
dc.identifier.citedreference | Hess RA, Bunick D., Lee KH, Bahr J., Taylor JA, Korach KS, Lubahn DB. A role for oestrogens in the male reproductive system. Nature. 1997; 390 ( 6659 ): 509 – 512. | en_US |
dc.identifier.citedreference | Hoppin JA, Brock JW, Davis BJ, Baird DD. Reproducibility of urinary phthalate metabolites in first morning urine samples. Environ Health Perspect. 2002; 110 ( 5 ): 515 – 518. | en_US |
dc.identifier.citedreference | Jonsson BA, Richthoff J., Rylander L., Giwercman A., Hagmar L.. Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology. 2005; 16 ( 4 ): 487 – 493. | en_US |
dc.identifier.citedreference | Kim HS, Saito K., Ishizuka M., Kazusaka A., Fujita S.. Short period exposure to di‐(2‐ethylhexyl) phthalate regulates testosterone metabolism in testis of prepubertal rats. Arch Toxicol. 2003; 77 ( 8 ): 446 – 451. | en_US |
dc.identifier.citedreference | Kleinbaum DG, Kupper LL, Muller KE, Nizam A.. Selecting the Best Regression Equation. Applied Regression Analysis and Other Multivariate Methods. 3rd ed. Pacific Grove, CA: Brooks/Cole Publishing Company; 1998. | en_US |
dc.identifier.citedreference | Li LH, Jester WF Jr, Orth JM. Effects of relatively low levels of mono‐(2‐ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats. Toxicol Appl Pharmacol. 1998; 153 ( 2 ): 258 – 265. | en_US |
dc.identifier.citedreference | Liu PY, Handelsman DJ. The present and future state of hormonal treatment for male infertility. Hum Reprod Update. 2003; 9 ( 1 ): 9 – 23. | en_US |
dc.identifier.citedreference | Lovekamp TN, Davis BJ. Mono‐(2‐ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells. Toxicol Appl Pharmacol. 2001; 172 ( 3 ): 217 – 224. | en_US |
dc.identifier.citedreference | Main KM, Mortensen GK, Kaleva MM, Boisen KA, Damgaard IN, Chellakooty M., Schmidt IM, Suomi AM, Virtanen HE, Petersen DV, Andersson AM, Toppari J., Skakkebaek NE. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect. 2006; 114 ( 2 ): 270 – 276. | en_US |
dc.identifier.citedreference | Meeker JD, Calafat AM, Hauser R.. Di(2‐ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men. Environ Health Perspect. 2007; 115 ( 7 ): 1029 – 1034. | en_US |
dc.identifier.citedreference | Meeker JD, Singh NP, Hauser R.. Serum concentrations of estradiol and free T4 are inversely correlated with sperm DNA damage in men from an infertility clinic. J Androl. 2008; 29 ( 4 ): 379 – 388. | en_US |
dc.identifier.citedreference | Noda M., Ohno S., Nakajin S.. Mono‐(2‐ethylhexyl) phthalate (MEHP) induces nuclear receptor 4A subfamily in NCI‐H295R cells: a possible mechanism of aromatase suppression by MEHP. Mol Cell Endocrinol. 2007; 274 ( 1–2 ): 8 – 18. | en_US |
dc.identifier.citedreference | Peck CC, Albro PW. Toxic potential of the plasticizer Di(2‐ethylhexyl) phthalate in the context of its disposition and metabolism in primates and man. Environ Health Perspect. 1982; 45: 11 – 17. | en_US |
dc.identifier.citedreference | Pentikainen V., Erkkila K., Suomalainen L., Parvinen M., Dunkel L.. Estradiol acts as a germ cell survival factor in the human testis in vitro. J Clin Endocrinol Metab. 2000; 85 ( 5 ): 2057 – 2067. | en_US |
dc.identifier.citedreference | Pflieger‐Bruss S., Schuppe HC, Schill WB. The male reproductive system and its susceptibility to endocrine disrupting chemicals. Andrologia. 2004; 36 ( 6 ): 337 – 345. | en_US |
dc.identifier.citedreference | Schiff JD, Ramirez ML, Bar‐Chama N.. Medical and surgical management male infertility. Endocrinol Metab Clin North Am. 2007; 36 ( 2 ): 313 – 331. | en_US |
dc.identifier.citedreference | Schrader SM, Turner TW, Breitenstein MJ, Simon SD. Measuring male reproductive hormones for occupational field studies. J Occup Med. 1993; 35 ( 6 ): 574 – 576. | en_US |
dc.identifier.citedreference | Silva MJ, Barr DB, Reidy JA, Malek NA, Hodge CC, Caudill SP, Brock JW, Needham LL, Calafat AM. Urinary levels of seven phthalate metabolites in the US population from the National Health and Nutrition Examination Survey (NHANES) 1999–2000. Environ Health Perspect. 2004b; 112 ( 3 ): 331 – 338. | en_US |
dc.identifier.citedreference | Silva MJ, Malek NA, Hodge CC, Reidy JA, Kato K., Barr DB, Needham LL, Brock JW. Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography‐atmospheric pressure chemical ionization tandem mass spectrometry. J Chromatogr B. 2003; 789 ( 2 ): 393 – 404. | en_US |
dc.identifier.citedreference | Silva MJ, Slakman AR, Reidy JA, Preau JL Jr, Herbert AR, Samandar E., Needham LL, Calafat AM. Analysis of human urine for fifteen phthalate metabolites using automated solid‐phase extraction. J Chromatogr B. 2004a; 805 ( 1 ): 161 – 167. | en_US |
dc.identifier.citedreference | Swan SH, Main KM, Liu F., Stewart SL, Kruse RL, Calafat AM, Mao CS, Redmon JB, Ternand CL, Sullivan S., Teague JL. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect. 2005; 113 ( 8 ): 1056 – 1061. | en_US |
dc.identifier.citedreference | Teass AW, Biagini RE, DeBord DG, Hull RD. Application of biological monitoring methods. In: Eller PM, ed. NIOSH Manual of Analytical Methods. Cincinnati, OH: National Institute for Occupational Safety and Health; 1998; 52 – 62. | en_US |
dc.identifier.citedreference | Teitelbaum SL, Britton JA, Calafat AM, Ye X., Silva MJ, Reidy JA, Galvez MP, Brenner BL, Wolff MS. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ Res. 2008; 106 ( 2 ): 257 – 269. | en_US |
dc.identifier.citedreference | Toft G., Hagmar L., Giwercman A., Bonde JP. Epidemiological evidence on reproductive effects of persistent organochlorines in humans. Reprod Toxicol. 2004; 19 ( 1 ): 5 – 26. | en_US |
dc.identifier.citedreference | Travison TG, Araujo AB, O'Donnell AB, Kupelian V., McKinlay JB. A population‐level decline in serum testosterone levels in American men. J Clin Endocrinol Metab. 2007; 92 ( 1 ): 196 – 202. | en_US |
dc.identifier.citedreference | Vermeulen A., Verdonck G.. Representativeness of a single point plasma testosterone level for the long term hormonal milieu in men. J Clin Endocrinol Metab. 1992; 74 ( 4 ): 939 – 942. | en_US |
dc.identifier.citedreference | Andersson AM, Jensen TK, Juul A., Petersen JH, Jorgensen T., Skakkebaek NE. Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys. J Clin Endocrinol Metab. 2007; 92 ( 12 ): 4696 – 4705. | en_US |
dc.identifier.citedreference | Andrade AJ, Grande SW, Talsness CE, Grote K., Chahoud I.. A dose‐response study following in utero and lactational exposure to di‐(2‐ethylhexyl)‐phthalate (DEHP): non‐monotonic dose‐response and low dose effects on rat brain aromatase activity. Toxicology. 2006; 227 ( 3 ): 185 – 192. | en_US |
dc.identifier.citedreference | ATSDR. Toxicological Profile for Diethyl Phthalate (DEP). Atlanta, GA: Agency for Toxic Substances and Disease Registry; 1995. | en_US |
dc.identifier.citedreference | ATSDR. Toxicological Profile for Di‐n‐butyl Phthalate (DBP). Atlanta, GA: Agency for Toxic Substances and Disease Registry; 2001. | en_US |
dc.identifier.citedreference | ATSDR. Toxicological Profile for Di(2‐ethylhexyl)phthalate (DEHP). Atlanta, GA: Agency for Toxic Substances and Disease Registry; 2002. | en_US |
dc.identifier.citedreference | Bain J., Langevin R., D'Costa M., Sanders RM, Hucker S.. Serum pituitary and steroid hormone levels in the adult male: one value is as good as the mean of three. Fertil Steril. 1988; 49 ( 1 ): 123 – 126. | en_US |
dc.identifier.citedreference | Bjornerem A., Straume B., Oian P., Berntsen GK. Seasonal variation of estradiol, follicle stimulating hormone, and dehydroepiandrosterone sulfate in women and men. J Clin Endocrinol Metab. 2006; 91 ( 10 ): 3798 – 3802. | en_US |
dc.identifier.citedreference | Blount BC, Milgram KE, Silva MJ, Malek NA, Reidy JA, Needham LL, Brock JW. Quantitative detection of eight phthalate metabolites in human urine using HPLC‐APCI‐MS/MS. Anal Chem. 2000; 72 ( 17 ): 4127 – 4134. | en_US |
dc.identifier.citedreference | Borch J., Metzdorff SB, Vinggaard AM, Brokken L., Dalgaard M.. Mechanisms underlying the anti‐androgenic effects of diethylhexyl phthalate in fetal rat testis. Toxicology. 2006; 223 ( 1–2 ): 144 – 155. | en_US |
dc.identifier.citedreference | Carreau S., Delalande C., Silandre D., Bourguiba S., Lambard S.. Aromatase and estrogen receptors in male reproduction. Mol Cell Endocrinol. 2006; 246 ( 1–2 ): 65 – 68. | en_US |
dc.identifier.citedreference | CDC. Third National Report on Human Exposure to Environmental Chemicals. Washington, DC: Centers for Disease Control and Prevention; 2005. | en_US |
dc.identifier.citedreference | CDC. NHANES 2003–2004 laboratory files, lab 24: urinary phthalates. Atlanta, GA: US Centers for Disease Control and Prevention; 2008 http:www.cdc.govnchsaboutmajornhanesnhanes20032004lab03_04.htm. Accessed June 27, 2008. | en_US |
dc.identifier.citedreference | Corton JC, Bocos C., Moreno ES, Merritt A., Cattley RC, Gustafsson JA. Peroxisome proliferators alter the expression of estrogen‐metabolizing enzymes. Biochimie. 1997; 79 ( 2–3 ): 151 – 162. | en_US |
dc.identifier.citedreference | David RM, McKee RH, Butala JH, Barter RA, Kayser M.. Esters of aromatic mono‐, di‐, and tricarboxylic acids, aromatic diacids, and di‐, tri‐, or polyalcohols. In: Bingham E., Cohrssen B., Powell CH eds. Patty's Toxicology. New York, NY: John Wiley and Sons; 2001: 635 – 932. | en_US |
dc.identifier.citedreference | Davis BJ, Weaver R., Gaines LJ, Heindel JJ. Mono‐(2‐ethylhexyl) phthalate suppresses estradiol production independent of FSH‐cAMP stimulation in rat granulosa cells. Toxicol Appl Pharmacol. 1994; 128 ( 2 ): 224 – 228. | en_US |
dc.identifier.citedreference | Duty SM, Calafat AM, Silva MJ, Ryan L., Hauser R.. Phthalate exposure and reproductive hormones in adult men. Hum Reprod. 2005; 20 ( 3 ): 604 – 610. | en_US |
dc.identifier.citedreference | Fleming LE, Bean JA, Rudolph M., Hamilton K.. Cancer incidence in a cohort of licensed pesticide applicators in Florida. J Occup Environ Med. 1999; 41 ( 4 ): 279 – 288. | en_US |
dc.identifier.citedreference | Foster PM. Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl. 2006; 29 ( 1 ): 140 – 147; discussion 181–185. | en_US |
dc.identifier.citedreference | Fromme H., Bolte G., Koch HM, Angerer J., Boehmer S., Drexler H., Mayer R., Liebl B.. Occurrence and daily variation of phthalate metabolites in the urine of an adult population. Int J Hyg Environ Health. 2007; 210 ( 1 ): 21 – 33. | en_US |
dc.identifier.citedreference | Ge RS, Chen GR, Dong Q., Akingbemi B., Sottas CM, Santos M., Sealfon SC, Bernard DJ, Hardy MP. Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats. J Androl. 2007; 28 ( 4 ): 513 – 520. | en_US |
dc.identifier.citedreference | Hauser R., Meeker JD, Duty S., Silva MJ, Calafat AM. Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology. 2006; 17 ( 6 ): 682 – 691. | en_US |
dc.identifier.citedreference | Hauser R., Meeker JD, Park S., Silva MJ, Calafat AM. Temporal variability of urinary phthalate metabolite levels in men of reproductive age. Environ Health Perspect. 2004; 112 ( 17 ): 1734 – 1740. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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